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                    John Gay, DVM PhD DACVPM               AAHP                  FDIU             VCS

VMS 576 Introduction to Clinical Research - 2013

last update April 04, 2013

Purpose:

Provide links to handout and on-line materials for this year's class

Week 1:

Handouts:

• 2013 Syllabus - pdf  - click through hot links in pdf
• Research Flow - pdf
• 2013 Proposal Format for Call for Graduate Student and House Officer Research Proposals - pdf
• Research Outline and Précis - Guide pdf    Template docx

View and note key points about the review process and what makes proposals outstanding:

• NIH Peer Review Revealed - YouTube
• NIH Tips for Applicants - YouTube

Obtain and read:

• Chapters 1 and 2 in Holmes and Cockcroft, Hulley et al., or Portney and Watkins
• Chapters 1 and 2 in Ruxton and Colegrove
• Chapters 1 "Getting Started" and 2 "Plan Your Research" in Tacker (Research Handbook for Veterinary Residents)
• Picking a Research Problem - The Critical Decision (NEJM 330:1530-1533, 1994) - online and pdf
• Choosing a research question (Asia Pacific Family Medicine 2:42-44, 2002) - online pdf

Week 2: Bibliographic software

Handouts:

• Research outline and précis scoring rubric - pdf
• Research Pathways - pdf
• Clinical study design tree, study weak points, and their correction - pdf
• Ishikawa (Fishbone) Variance Diagram - pdf

Glossaries:

• Clinical Study Design and Methods Terminology and Experimental Design and Statistics Terminology glossaries are part of my on-line Clinical Epidemiology and Evidence Based Medicine Glossary. Reviewers will be looking for many of these terms and their correct use in your proposals.

Readings for next week:

• Searching the Veterinary Literature: A Comparison of the Coverage of Veterinary Journals by Nine Bibliographic Databases, Journal of Veterinary Medical Education 39(4):404-412. DOI 10.3138/jvme.1111.109R
  • pdf link
• Understanding and Evaluating Veterinary Clinical Research, Journal of the American Animal Hospital Association Sep/Oct 201248:285-298;
  • pdf link

Week 3: Searching bibliographic databases

Exchange first precis draft

Week 4:

Week 5: Reviewers provide peer review to authors

Week 6: Sample size

Resources:

• G van Belle (2008). Statistical Rules of Thumb, 2^nd ed. Chapter 2: Sample Size - pdf
• SK Lwanga, S Lemeshow (1991). Sample Size Determination in Health Studies: A Practical Manual - WHO pdf

Week 7: Allocation

Exchange second precis draft

Handouts:

• The "Paramedic Method" - pdf
• Scientific writing word usage - pdf
• Extracts from Dr. Steve Russell’s “The Grant Application Writer’s Workbook”

Week 8: Reviewers provide peer review to authors

Week 9:

Handouts:

• CR - Initial statistical analysis - pdf
• Why proposals are rejected - pdf
• Combined resident grant reviews (anonymous) - pdf

Spring Break

Week 10: Exchange first proposal draft

Handouts:

• Speaking with PowerPoint: Tips, traps and rules of thumb - PowerPoint handout pdf
• Grant proposal draft scoring rubric - pdf  

Week 11: Reviewers provide peer review to authors

Week 12: Reviewers provide peer review to authors (continued)

Week 13: Exchange 2^nd proposal draft

• Discuss other proposal submission components - REX, IACUC ASAF, IRB, budget approval

Week 14: Reviewers provide peer review to authors

Week 15: Completed proposals due to VCS Research Committee on Monday, April 22

8:10 - OGRD presentation on locating extramural grant funding sources (reserve projector and laptop)

Due Dates: (updated 4/4/13)