College of Veterinary Medicine

Veterinary Clinical Pharmacology Lab

Affected Breeds


  Collie Dog
Approximately 3 of every 4 Collies in the United States have the mutant MDR1 gene. The frequency is about the same in France and Australia, so it is likely that most Collies worldwide have the mutation. The MDR1 mutation has also been found in Shetland Sheepdogs (Shelties). Australian Shepherds, Old English Sheepdogs, German Shepherds, Long-haired Whippets, Silken Windhounds, and a variety of mixed breed dogs.


The only way to know if an individual dog has the mutant MDR1 gene is to have the dog tested. As more dogs are tested, more breeds will probably be added to the list of affected breeds.



Collie bloodlines turn up surprising relatives from MSNBC News. Aug 3, 2004

Last Edited: Jun 22, 2007 4:55 PM
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