Explanation of Test Results
Normal/Normal - These dogs do not carry the mutation, and will
not pass on the mutation to their offspring. These dogs would not be expected to
experience unexpected adverse drug reactions to normal doses of ivermectin,
loperamide (Imodium), and some anticancer drugs.
Mutant/Mutant - These dogs carry the mutation and will pass on
the mutant gene to their offspring. These dogs would be expected to experience
toxicity after normal doses of loperamide (Imodium), and some anticancer drugs,
and high doses of ivermectin (greater than 50 micrograms per kilogram).
Mutant/Normal - These dogs carry the mutation and may pass on
the mutant gene to their offspring. These dogs may experience toxicity after
normal doses of loperamide (Imodium), and some anticancer drugs, and high doses
of ivermectin (greater than 50 micrograms per kilogram)
