In the Media
Articles about the college from around the world.
Two Neuroscience Undergraduates Win ABRCMS AwardsNeuroscience undergraduate researchers Collin Warrick and Carlie Knox received awards for their posters at the Annual Biomedical Research Conference for Minority Students (ABRCMS) in the Neuroscience category.
PrIMe graduate student identifies gene essential for effective pain treatment in dogsTramadol is one of the most widely prescribed drugs for treatment of mild to moderate pain in dogs. However, there is growing evidence that this drug may not work well in some patients because of genetic differences. Dr. Tania E. Perez-Jimenez (DVM, MS), a graduate student in Dr. Michael Court’s Pharmacogenomics laboratory, has identified a gene that is essential for “turning on” the pain relieving effects of tramadol in dogs. The gene called CYP2D15 produces an enzyme that converts tramadol into M1. Tramadol by itself lacks any pain relieving effects and must first be converted into M1 in the liver before it can alleviate pain. A related gene in humans (CYP2D6) produces a similar enzyme that is essential for forming M1 from tramadol in people. However, tramadol is ineffective for treating pain in 5 to 10% of people because they have a mutation in CYP2D6 and do not produce sufficient amounts of M1. Consequently, the next step in the project is to determine whether there are mutations in the canine CYP2D15 gene that could also explain why some dogs do not achieve adequate pain relief from tramadol. Dr. Perez’s discoveries were recently reported in the journal Drug Metabolism and Disposition (PMID: 27758804), and were funded by a Morris Animal Foundation Training Fellowship and the William R. Jones Endowment at WSU. Read More
Thermotolerant vaccines: A game changer?
The Serengeti Health Initiative (SHI)—co-funded by Washington State University and Lincoln Park Zoo (Chicago)—has, since 2003, been controlling rabies through the implementation of annual mass dog rabies vaccination campaigns in remote villages in northern Tanzania.
25 undergraduates receive awards to conduct researchWSU disseminated undergraduate research awards to students across campus in support of their projects. SMB research labs were well represented, including:
- Grace Carrell, Microbiology major, Alan Goodman's lab
- Zachary Howard, Genetics and Cell Biology major, Alan Goodman's lab
- Estifanos Kassa, Microbiology major, Rey Carabeo's lab
- Marina Martin, Biochemistry major (pre-medicine), Alan Goodman's lab
- Elizabeth Rice-Reynolds, Genetics and Cell Biology major, Michael Griswold's lab
- Seth Schneider, Genetics and Cell Biology major (STARS Program), Anthony Nicola's lab (Department of Veterinary Microbiology and Pathology)
Research finds possible link between cattle, human diseaseWSU News Posts
25 undergraduates receive awards to conduct researchWSU News
Dr. Ilia Karatsoreos has received the Dean's Outstanding Junior Faculty Research AwardThe 2016 Dean's Outstanding Junior Faculty Research Award has been given to Dr. Ilia Karatsoreos for his research on circadian rhythms, sleep, and stress.
The 18th Annual College of Veterinary Medicine Student and Post-Doctoral Research SymposiumOctober 27, 2016
Winners who are part of the CRB:
1. Trainee Seth Schneider (CRB faculty member Anthony Nicola)
2. Dr. Ilia Karatsoreos
Category 2 poster awardees: DVM student, undergraduate, and intern projects
First: Seth Schneider, poster title “Re-purposing an anticancer drug to combat herpes simplex virus infection.” Advisor: Anthony Nicola, Department of Veterinary Microbiology and Pathology.
Faculty research award:
Congratulations to Dr. Ilia Karatsoreos, Assistant Professor in the Department of Integrative Physiology and Neuroscience, for being selected as this year’s recipient of the Dean’s Outstanding Junior Faculty Research Award. This award recognizes outstanding early career faculty who are already establishing themselves as innovators and leaders in their chosen fields. Dr. Karatsoreos was recognized for his pioneering work on circadian rhythms, sleep, and stress.
The award was presented by Dean Bryan Slinker.
Rabies vaccine found effective even after warm storageA Washington State University-led research team determined rabies vaccines stored at warmer temperatures still protect against the disease in dogs.
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Veterinary professor named to international scientific panelDon Knowles, a U.S. Department of Agriculture research veterinary medical officer and professor in Washington State University’s College of Veterinary Medicine, is one of 16 people named to an international scientific advisory panel. Read More
Soybean nitrogen breakthrough could help feed the world
By Will Ferguson, College of Arts & Sciences
Her greenhouse-grown soybean plants fix twice as much nitrogen from the atmosphere as their natural counterparts, grow larger and produce up to 36 percent more seeds.
Tegeder designed a novel way to increase the flow of nitrogen, an essential nutrient, from specialized bacteria in soybean root nodules to the seed-producing organs. She and Amanda Carter, a biological sciences graduate student, found the increased rate of nitrogen transport kicked the plants into overdrive.
Their work, published recently in Current Biology, is a major breakthrough in the science of improving crop yields. It could eventually help address society’s critical challenge of feeding a growing human population while protecting the environment. See the paper athttp://www.sciencedirect.com/science/article/pii/S0960982216306157.
“The biggest implication of our research is that by ramping up the natural nitrogen allocation process we can increase the amount of food we produce without contributing to further agricultural pollution,” Tegeder said. “Eventually we would like to transfer what we have learned to other legumes and plants that humans grow for food.”
Improving grain yields
Legumes account for around 30 percent of the world’s agricultural production. They consist of plants like soybeans, alfalfa, peas, beans and lentils, among others.
Unlike crops that rely on naturally occurring and artificially made nitrogen from the soil, legumes contain rhizobia bacterioids in their root nodules that have the unique capability of converting or “fixing” nitrogen gas from the atmosphere.
For years, scientists have tried to increase the rate of nitrogen fixation in legumes by altering rhizobia bacterioid function or interactions that take place between the bacterioid and the root nodule cells.
Tegeder took a different approach: She increased the number of proteins that help move nitrogen from the rhizobia bacteria to the plant’s leaves, seed-producing organs and other areas where it is needed.
The additional transport proteins sped up the overall export of nitrogen from the root nodules. This initiated a feedback loop that caused the rhizobia to start fixing more atmospheric nitrogen, which the plant then used to produce more seeds.
“They are bigger, grow faster and generally look better than natural soybean plants,” Tegeder said. “Some evidence we have suggests they might also be highly efficient under stressful conditions like drought.”
Protecting the environment
Nitrogen is a macronutrient essential for plant growth. Large amounts of synthetic nitrogen fertilizer are applied around the world to ensure high plant productivity.
Application is an environmental issue in industrialized countries like the United States because of high energy input, increased greenhouse gas emissions, water pollution and other adverse effects on ecosystems and human health.
In developing countries, where nitrogen fertilizer is scarce, insufficient plant nitrogen results in low crop yields and limited food supplies.
Tegeder thinks her soybean-focused research can eventually be applied to varieties of legumes suited for a diverse array of climates. One major benefit of growing legumes such as chickpeas, common beans, peas and soybeans is that they not only can use atmospheric nitrogen for their own growth but also leave residual nitrogen in the soil for subsequent crops.
Hence, increasing nitrogen fixation could improve overall plant productivity for farmers who grow legumes in both industrial and developing countries while diminishing or eliminating the need for nitrogen fertilizers.
“Legumes with higher yields have huge implications for agriculture and food production around the world,” Tegeder said. “Our research also has the potential to be transferred to other crop plants that don’t fix nitrogen from the atmosphere but would benefit from being able to uptake nitrogen more efficiently from the soil.”
Her work is in keeping with WSU’s Grand Challenges, a suite of research initiatives aimed at large societal issues. It is particularly relevant to the challenge of sustainable resources and its theme of supplying food for future generations.
This work was supported by grants from the National Science Foundation (IOS 1021286 and IOS 1457183) and the U.S. Department of Agriculture, National Institute of Food and Agriculture (2010-65115-20382).
Mechthild Tegeder, WSU School of Biological Sciences, 509-335-7545, firstname.lastname@example.org
Dr. Emily Pieracci (DVM '09) "Former Richland woman makes difference through CDC"Dr. Emily Pieracci (DVM '09) "Former Richland woman makes difference through CDC"
Tom Besser received a new USDA grantTom Besser (VMP; Rocky Crate Chair) received a new USDA grant to develop a generalized approach to risk identification with regard to livestock-wildlife interactions and the potential for transmission of infectious disease; this addresses an important area of policy in the West with regard to, for example, Rocky Mountain Sheep-domestic sheep interactions in many parts of the West, including Idaho and Washington.
WSU team offers rabies vaccines in East AfricaThe Paul Allen School for Global Animal Health at WSU is working to eliminate canine rabies worldwide by vaccinating dogs in East Africa.
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WSU Eliminate Rabies program reaches 50,000 dog vaccinations
PULLMAN, Wash. – More than 99 percent of the people infected with rabies get it from the bite of an unvaccinated dog. Washington State University believes it can prevent those infections.Read More Read More
Gene-editing breakthrough could be boon to cattle producers.
- Fall 2016 Northwest Farm and Ranch by the Lewiston Tribune (Read full issue) Lewiston Tribune
Dr. Jaak Panksepp on The science of laughterBBC Special on the science of laughter with Dr. Jaak Panksepp
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PrIMe research team develops assay for immunosuppressant drug to improve its safe use in dogs and catsMycophenolic acid (MPA) is the active metabolite of the immunosuppressant prodrug mycophenolate mofetil. In this study, we developed and validated a novel ultra-high performance liquid chromatography (UHPLC) method for the rapid quantification of MPA in plasma from dogs, cats and humans. The advantages of this method include: high sensitivity and reproducibility over a wide range of MPA plasma concentrations, small sample volume and easy sample preparation. By combining isocratic conditions with a UHPLC column containing solid core particles, we were able to elute MPA within 3.0 min. The very short chromatographic analysis time makes this method ideal to study the disposition of MPA in large batches of plasma samples and/or monitor plasma drug concentrations, as recommended for patients that require optimized immunosuppression. Read More
Probiotics-and-vaccine treatments fight coldwater disease in rainbow troutRead More
Targeted drug makes alcohol guzzling mouse a teetotalerRead More