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Date: Wed, 10 Mar 2004 17:40:29 -0700
Author: David Twedt
Body: Hi GI people,

I have an unusual esophageal case - any ideas or have you seen a similar thing?

1.4 year old female Boxer presented for regurgitation of 9 mos duration. (Signs seemed to occur at about the time of an OHE).  Dog is thin, hungry and with regurgitation of almost all food.  Does better with liquids.

Routine chest films normal with no esophageal dilation.

Contrast study shows sluggish motility in cervical esophagus then a 10 cm area of narrowing starting at the thoracic inlet, followed by normal esophagus with sluggish motility (both primary and secondary contractions). The narrowed area would however on occasion open somewhat maybe 1-2 cm.

On endoscopy the proximal esophagus opens well with air, the narrowed area does not open but it is easy to pass the endoscope through, and the distal esophagus appears normal.  The narrowed area looked like normal uninsufflated esophagus with linear rugal folds.

I placed a 3 cm diameter balloon in the area and it was easy to dilate with no resistance.

Repeat endoscopy following the balloon was similar as the first one.  

My impression is this dog has a neuromuscular disorder possibly segmental with failure of relaxation in this area.  I plan on doing manometry on the esophagus (haven't had an indication to do this in many years so need to try to get the cob webs off the instruments).  Our radiologist of many years experience hasn't seen anything similar.

A last tidbit was a litter mate had a reported esophageal problem and was euthanized at a young age.  It reminds me of a nutcracker esophagus reported in people treated with Ca channel blockers with some success (however that is smooth muscle).  Any ideas or thoughts on diagnostics, treatment?

Thanks for any advice,

David Twedt
Colorado State University

 

proximal-esophagus---twedt.jpg (110287 bytes)
Figure 1. Endoscopic image of proximal esophagus.
(Dr. David Twedt, CSU)

Narrowing--twedt.jpg (113177 bytes)
Figure 2.
Endoscopic image as approach the narrowing, near the mid-esophagus.
(Dr. David Twedt, CSU)

Narrow-area---twedt.jpg (108659 bytes)
Figure 3. Endoscopic image of the narrow area in mid-esophagus.
(Dr. David Twedt, CSU)

Distal-esophagus5---twedt.jpg (108018 bytes)
Figure 4. Endoscopic image of the distal esophagus.
(Dr. David Twedt, CSU)

Date: Wed, 10 Mar 2004 19:06:21 -0600
Author: Lisa Moore
Body: David:

I had a similar case, also in a young Boxer.  The dog did not do well and was euthanized.  He had what our pathologists determined to be segmental muscular dystrophy (Figure 5).  I had great intentions of publishing this case, but have not yet gotten around to it!

Maybe this helps.

Lisa

Lisa E. Moore, DVM
Diplomate ACVIM-SAIM
Section Head-Small Animal Medicine
Assistant Professor
Kansas State University

 

Lisa-Moore's-case-4---moore.jpg (93573 bytes)
Figure 5. Post-mortem specimen from a similar case of esophageal narrowing in a young boxer.
(Lisa Moore, KSU)

 

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