Cleverson D Souza, DVM, MSc, Ph.D., DACVP
Assistant Professor of Clinical Pathology
Veterinary Clinical Sciences, College of Veterinary Medicine
Phone: +1 (509).335.0726 - Skype: deso0017
Office: 2031 ADBF, PO Box 646610
Pullman, WA, 99164-6610
Ph.D - Infection Diseases track, University of Minnesota, St Paul, MN.
Project: Host-pathogen interaction in Mycobacterium avium subsp.
paratuberculosis infection: Role of the mitogen activated protein kinases
in regulating antimicrobial responses of mononuclear phagocytes
MSc - Immunology track, Federal University of Santa Maria, RS, Brazil. Project:
Evaluation of the neutrophilic oxidative burst in Saanen goats naturally
infected by Haemonchus contortus
Residency in Veterinary Clinical Pathology - Universidade Estadual Paulista/UNESP,
SP, Brazil and University of Minnesota, MN, USA
DVM - Federal University of Parana, PR, Brazil
American College of Veterinary Pathologists, 2011 - Present
Dr. Cleverson Souza is a board certified Assistant Professor of Veterinary
Clinical Pathology. Dr. Souza’s current research investigates Mycobacterium
avium subsp paratuberculosis (MAP) lipidomics and MAP-infected macrophage
and dendritic cell biology. Clinical research investigate the role of the r-EPO
in dog’s lymphosarcoma and the application of modern teaching methods to teach
Veterinary Clinical Pathology.
SOUZA C, et al., Mannosylated Lipoarabinomannans from Mycobacterium Avium
Subsp. Paratuberculosis Alters the Inflammatory Response by Bovine Macrophages
and Suppresses Killing of Mycobacterium avium subsp. avium Organisms.
PLoS ONE 8(9):e75924. doi:10.1371, 2013
Weiss, DJ and SOUZA, CD. Modulation of Macrophage Function by Mycobacterium
avium subsp. paratuberculosis: A Review. Veterinary Pathology, 45:829-841, 2008
SOUZA, CD; Weiss, DJ, Evanson, O. Cell membrane receptors involved in
suppression of monocyte anti-microbial activity against Mycobacterium
paratuberculosis. Microbial Pathogenesis, Mar; 44(3):215-23, 2008
Weiss, DJ; SOUZA, CD; Evanson; O. Sanders; M, Rutherford M. Bovine monocyte
TLR2 receptors differentially regulate the intracellular fate of Mycobacterium
avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Journal of
Leukocyte Biology, Jan;83(1):48-55, 2008
Weiss, DJ; SOUZA, CD; Evanson, O. Nuclear factor-kB regulates cytokine
expression and apoptosis in bovine monocytes infected with Mycobacterium avium
subsp. paratuberculosis. American Journal of Veterinary Research,
SOUZA, CD; Weiss, DJ, Evanson, O. Role of the mitogen-activated protein
kinase pathway in the differential response of bovine monocytes to Mycobacterium
avium subsp. paratuberculosis and Mycobacterium avium subsp. avium, Microbes and
Infection, Nov-Dec;9(14-15):1545-52, 2007
SOUZA, CD; Weiss, DJ, Evanson, O. Role of the MAPK-ERK pathway regulating
cytokine expression by Mycobacterium avium subsp. paratuberculosis-infected
bovine monocytes. American Journal of Veterinary Research, Jun; 68(6):625-30,
SOUZA, CD; et al. Cell Membrane Receptors in Bovine Mononuclear Phagocytes
Involved in Phagocytosis of Mycobacterium avium subsp. paratuberculosis.
American Journal of Veterinary Research, Sept (68): 975-980, 2007
Santos, AP; Biondo, AW; Sisson, DD; Lopes, STA; SOUZA, CD; Solter, PF,.
Comparative sequences of the canine and feline vasopressin pro-hormones.
Comparative Clinical Pathology, (16):173-179, 2007.
SOUZA, CD; Weiss, DJ, Evanson, O. Mitogen Activated Protein Kinase-p38
pathway is an important component of the anti-inflammatory response in
Mycobacterium avium-infected bovine monocytes. Microbial Pathogenesis, v.
Weiss, DJ, SOUZA, CD, Evanson, O. Mucosal immune response in cattle with,
subclinical Johne's disease. Veterinary Pathology, (43): 127-135, 2006
SOUZA, CD; Weiss, DJ, Evanson, O. Jun n-terminal kinase (MAPK-JNK/SAPK)
regulates cytokine expression in Mycobacterium avium subsp. paratuberculosis-infected
bovine monocytes. American Journal of Veterinary Research, Vol. 67, No. 10:
SOUZA, CD; Lopes, STA, Batina, P, et al. Parasitic stress in Saanen Goats:
Evaluation of the CBC and neutrophilic oxidative burst. Revista Veterinaria
Noticias, v. 12, n. 2, p. 35-40, 2006.
Weiss, DJ, Evanson, O, SOUZA, CD. Expression of interleukin-10 and suppressor
of cytokine signaling-3 associated with susceptibility to Jonhe's disease.
American Journal of Veterinary Research, Jul;66 (7):1114-20, 2005