College of Veterinary Medicine

People in WSU Veterinary Medicine

Cleverson Souza


Cleverson Sousa

Cleverson D Souza, DVM, MSc, Ph.D., DACVP
Assistant Professor of Clinical Pathology
Veterinary Clinical Sciences, College of Veterinary Medicine
Phone: +1 (509).335.0726 - Skype: deso0017
Office: 2031 ADBF, PO Box 646610
Pullman, WA, 99164-6610
souza@vetmed.wsu.edu

 

Education

Ph.D - Infection Diseases track, University of Minnesota, St Paul, MN. Project: Host-pathogen interaction in Mycobacterium avium subsp. paratuberculosis infection: Role of the mitogen activated protein kinases in regulating antimicrobial responses of mononuclear phagocytes
 
MSc - Immunology track, Federal University of Santa Maria, RS, Brazil. Project: Evaluation of the neutrophilic oxidative burst in Saanen goats naturally infected by Haemonchus contortus
 
Residency in Veterinary Clinical Pathology - Universidade Estadual Paulista/UNESP, SP, Brazil and University of Minnesota, MN, USA
 
DVM - Federal University of Parana, PR, Brazil

Professional Affiliations  

American College of Veterinary Pathologists, 2011 - Present

Research Interests

Dr. Cleverson de Souza is a board certified Assistant Professor of Veterinary Clinical Pathology. Dr. Souza’s lab seeks to investigate the cell signaling pathways modulated upon Mycobacterium avium subsp paratuberculosis (MAP) early interaction with professional phagocytes. The lab also work trying to rationally apply these knowledge to generate an effective nanoparticle vaccine. Clinical research investigate the immune interactions of MAP and other intracellular pathogens with canine macrophages and dendritic cells. Applications of this research include novel vaccine designs and improved immune animal study models. Teaching interest include application of modern instructional methodologies (i.e., flipped classroom) to teach Veterinary Clinical Pathology.

Publications

SOUZA C, et al., Mannosylated Lipoarabinomannans from Mycobacterium Avium Subsp. Paratuberculosis Alters the Inflammatory Response by Bovine Macrophages and Suppresses Killing of Mycobacterium avium subsp. avium Organisms. PLoS ONE 8(9):e75924. doi:10.1371,  2013

Weiss, DJ and SOUZA, CD. Modulation of Macrophage Function by Mycobacterium avium subsp. paratuberculosis: A Review. Veterinary Pathology, 45:829-841, 2008

SOUZA, CD; Weiss, DJ, Evanson, O. Cell membrane receptors involved in suppression of monocyte anti-microbial activity against Mycobacterium paratuberculosis. Microbial Pathogenesis, Mar; 44(3):215-23, 2008

Weiss, DJ; SOUZA, CD; Evanson; O. Sanders; M, Rutherford M. Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Journal of Leukocyte Biology, Jan;83(1):48-55, 2008

Weiss, DJ; SOUZA, CD; Evanson, O. Nuclear factor-kB regulates cytokine expression and apoptosis in bovine monocytes infected with Mycobacterium avium subsp. paratuberculosis. American Journal of Veterinary Research, Jun;69(6):804-10, 2008

SOUZA, CD; Weiss, DJ, Evanson, O. Role of the mitogen-activated protein kinase pathway in the differential response of bovine monocytes to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium, Microbes and Infection, Nov-Dec;9(14-15):1545-52, 2007

SOUZA, CD; Weiss, DJ, Evanson, O. Role of the MAPK-ERK pathway regulating cytokine expression by Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes. American Journal of Veterinary Research, Jun; 68(6):625-30, 2007

SOUZA, CD; et al. Cell Membrane Receptors in Bovine Mononuclear Phagocytes Involved in Phagocytosis of Mycobacterium avium subsp. paratuberculosis. American Journal of Veterinary Research, Sept (68): 975-980, 2007

Santos, AP; Biondo, AW; Sisson, DD; Lopes, STA; SOUZA, CD; Solter, PF,. Comparative sequences of the canine and feline vasopressin pro-hormones. Comparative Clinical Pathology, (16):173-179, 2007.

SOUZA, CD; Weiss, DJ, Evanson, O. Mitogen Activated Protein Kinase-p38 pathway is an important component of the anti-inflammatory response in Mycobacterium avium-infected bovine monocytes. Microbial Pathogenesis, v. 41(2-3):59-66, 2006

Weiss, DJ, SOUZA, CD, Evanson, O. Mucosal immune response in cattle with, subclinical Johne's disease. Veterinary Pathology, (43): 127-135, 2006

SOUZA, CD; Weiss, DJ, Evanson, O. Jun n-terminal kinase (MAPK-JNK/SAPK) regulates cytokine expression in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes. American Journal of Veterinary Research, Vol. 67, No. 10: 1760-1765, 2006

SOUZA, CD; Lopes, STA, Batina, P, et al. Parasitic stress in Saanen Goats: Evaluation of the CBC and neutrophilic oxidative burst. Revista Veterinaria Noticias, v. 12, n. 2, p. 35-40,  2006.

Weiss, DJ, Evanson, O, SOUZA, CD. Expression of interleukin-10 and suppressor of cytokine signaling-3 associated with susceptibility to Jonhe's disease. American Journal of Veterinary Research, Jul;66 (7):1114-20, 2005

Last Edited: Jul 28, 2014 3:52 PM   

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