College of Veterinary Medicine

People in WSU Veterinary Medicine

Katrina Mealey


Katrina Mealey

Katrina Mealey DVM, PhD, Diplomate, ACVIM Internal Medicine
Diplomate, American College of Veterinary Clinical Pharmacology
Professor and Richard L. Ott Endowed Chair in Small Animal Medicine and Research

kmealey@vetmed.wsu.edu


Education

Bachelor of Science in Pharmacy at the University of New Mexico (1986) 
DVM Colorado State University (1990) 
PhD Texas A&M University (1998)
Small Animal Internship University of Minnesota (1991
Small Animal Internal Medicine Residency, Texas A&M University
Veterinary Clinical Pharmacology Residency, Texas A&M University

Research Interests

My primary research interest is pharmacogenetics, the study of genetic determinants of response to drug therapy. Most of my laboratory's current work focuses on the MDR1 polymorphism in herding breed dogs (Collies, Australian Shepherds, Shelties,etc), and its implications for multidrug sensitivity. Our laboratory is also beginning work to look at other breed-related adverse drug reactions in dogs.

Publications

Mealey KL, Bentjen SA, Gay JM, Cantor GH. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics. 2001 Nov;11(8):727-33.

Mealey KL, Northrup NC, Bentjen SA. Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity. J Am Vet Med Assoc. 2003 Nov 15;223(10):1453-5, 1434.

Neff MW, Robertson KR, Wong AK, Safra N, Broman KW, Slatkin M, Mealey KL, Pedersen NC. Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11725-30. Epub 2004 Aug 2.

Mealey KL, Munyard KA, Bentjen SA. Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in Australia.
Vet Parasitol. 2005 Aug 10;131(3-4):193-6.

Last Edited: Jan 18, 2013 4:08 PM   

Veterinary Clinical Sciences, PO Box 646610, Washington State University, Pullman WA 99164-6610, 509-335-0738, Contact Us  Safety Links