Katrina Mealey
Katrina Mealey DVM, PhD, Diplomate, ACVIM Internal Medicine
Diplomate, American College of Veterinary Clinical Pharmacology
Professor and Richard L. Ott Endowed Chair in Small Animal Medicine and
Research
kmealey@vetmed.wsu.edu
Education
Bachelor of Science in Pharmacy at the University of New Mexico (1986)
DVM Colorado State University (1990)
PhD Texas A&M University (1998)
Small Animal Internship University of Minnesota (1991
Small Animal Internal Medicine Residency, Texas A&M University
Veterinary Clinical Pharmacology Residency, Texas A&M University
Research Interests
My primary research interest is pharmacogenetics, the study of genetic
determinants of response to drug therapy. Most of my laboratory's current
work focuses on the MDR1 polymorphism in herding breed dogs (Collies,
Australian Shepherds, Shelties,etc), and its implications for multidrug
sensitivity. Our laboratory
is also beginning work to look at other breed-related adverse drug reactions
in dogs.
Publications
Mealey KL, Bentjen SA, Gay JM, Cantor GH. Ivermectin sensitivity in
collies is associated with a deletion mutation of the mdr1 gene.
Pharmacogenetics. 2001 Nov;11(8):727-33.
Mealey KL, Northrup NC, Bentjen SA. Increased toxicity of
P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1
deletion mutation associated with ivermectin sensitivity. J Am Vet Med
Assoc. 2003 Nov 15;223(10):1453-5, 1434.
Neff MW, Robertson KR, Wong AK, Safra N, Broman KW, Slatkin M, Mealey KL,
Pedersen NC. Breed distribution and history of canine mdr1-1Delta, a
pharmacogenetic mutation that marks the emergence of breeds from the collie
lineage. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11725-30. Epub 2004
Aug 2.
Mealey KL, Munyard KA, Bentjen SA. Frequency of the mutant MDR1 allele
associated with multidrug sensitivity in a sample of herding breed dogs
living in Australia.
Vet Parasitol. 2005 Aug 10;131(3-4):193-6.
