O. Lynne Nelson DVM, MS, Diplomate ACVIM (Internal Medicine, Cardiology)
Associate Professor
Cardiology
olnelson@vetmed.wsu.edu
Clinical Interests
Heart failure mechanisms and therapy, and interventional cardiology
Research Interests
Dr. Nelson's interest is understanding cardiac adaptations to extreme
hemodynamic and metabolic stressors, and comparing such naturally occurring
hemodynamics (bear hibernation) to congestive heart failure (dogs).
Current investigations include: Differential regulation of cardiac
β-adrenergic receptors and local myocardial adiponectin regulation in
hibernating bears (collaboration with
WSU Bear
Conservation and Education Research Facility) compared to dogs with
heart failure. In addition, I am investigating the role of grizzly bears as
a reverse translational model of cardiac disease as a result of obesity.
Dr. Nelson is a member scientist -Washington
Center for Muscle Biology (WCMB)
Research in the News-
http://nrs.wsu.edu/Research/Bear-Center/media.html
Selected Publications
Nelson OL, Rourke B. Increase in cardiac myosin
heavy-chain (MyHC) alpha protein isoform in hibernating ground squirrels
accompany ventricular hypertrophy and prolonged rates of contraction. J Exp
Biol,
Johns S, Nelson OL, Gay JM. Left atrial function in cats
with left-sided cardiac disease manifesting pleural effusion verses
pulmonary edema. JVIM, 2012 Sep-Oct;26(5):1134-9.
Jackson M, Rodgers BD, Luong D, Vang D, Garikipati D, Stanton J,
Nelson OL. Cardiac hypertrophy, enhanced stress response, reduced
adiposity and sexual dimorphism in aging myostatin null mice. J Endocrin,
2012; 263-275.
Robbins CT, Lopez-Alfaro C, Rode K, Toien O, Nelson OL.
Hibernation and seasonal fasting in bears: the energetic costs and
consequences for polar bears. J Mammology. 2012; 93(6):1493-1503.
Barrows N, Nelson OL, Robbins CT, Rourke B. Increased
cardiac alpha myosin heavy-chain in left atria and decreased myocardial
IGF-I expression accompanies hibernation-induced bradycardia in grizzly
bears. Physiol Biochem Zool. 2011 Jan-Feb;84(1):1-17.
Maran BA, Meurs KM, Lahmers SM, Nelson OL. Identification
of Beta-1 adrenergic receptor polymorphisms in cats. Res Vet Sci, 2012;
Aug;93(1):210-2.
Nelson OL, Robbins CT. Cardiac function adaptations in
hibernating grizzly bears (Ursus arctos horribilis). J Comp Physiol B 2009
Nov 26. J Comp Physiol B. 2010 Mar;180(3):465-73.
Rodgers BD, Interlichia JP, Garikipati DK, Mamidi R, Chandra M,
Nelson OL, Murry CE, Santana LF. Myostatin represses physiological
hypertrophy of the heart and excitation-contraction coupling. J Physiol.
2009 Oct 15;587(Pt 20):4873-86.
McGee-Lawrence ME, Wojda SJ, Barlow LN, Drummer TD, Castillo AB, Kennedy O,
Condon KW, Auger J, Black HL, Nelson OL, Robbins CT,
Donahue SW. Grizzly bears (Ursus arctos horribilis) and black bears (Ursus
americanus) prevent trabecular bone loss during disuse (hibernation). Bone.
2009 Dec;45(6):1186-91
Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL,
Rost K, King NM, Yu Q, Tschpe C, McNabb M, Larson DF, Labeit S, Gotthardt M.
Truncation of titin's elastic PEVK region leads to cardiomyopathy with
diastolic dysfunction.Circ Res. 2009 Sep 11;105(6):557-64.
Nelson OL, Robbins CT, Wu Y, Granzier H. Titin isoform
switching is a major adaptive response in hibernating grizzly bears. Am J
Physiol Heart Circ Physiol 2008 Jul;295(1):H336-71.
Hershey JD, Robbins CT, Nelson OL, Lin DC. Minimal seasonal
alterations in the skeletal muscle of captive brown bears. Physiol Biochem
Zool. 2008 March/April;81(2):138-147.
Davidson BJ, Paling AC, Lahmers SM, Nelson OL. Disease
Association and Clinical Assessment of Feline Pericardial Effusion. J Am
Anim Hosp Assoc 2008 44: 5-9.
McGee ME, Maki AJ, Johnson SE, Nelson OL, Robbins CT,
Donahue SW. Decreased bone turnover with balanced resorption and formation
prevent cortical bone loss during disuse (hibernation) in grizzly bears.
Bone. 2008 Feb;42(2):396-404.
Radke M, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H,
Gotthardt M. Targeted deletion of Titin's N2B region leads to diastolic
dysfunction and cardiac atrophy. PNAS 2007;104(9):3444-3449.
Nelson OL, Lahmers S, Schneider T, Thompson P. The use of
an implantable cardioverter defibrillator in a boxer dog to control clinical
signs of Arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med
2006;20:1232-1237.
Nelson OL, McEwen MM, Robbins CT, et al. Cardiac function
in active and hibernating grizzly bears. J Am Vet Med Assoc
2003;223:1170-1175.
