College of Veterinary Medicine

People in WSU Veterinary Medicine

O. Lynne Nelson 

Lynn Nelson

O. Lynne Nelson DVM, MS, Diplomate ACVIM (Internal Medicine, Cardiology)
Associate Professor 

Clinical Interests

Heart failure mechanisms and therapy, and interventional cardiology

Research Interests

Dr. Nelson's interest is understanding cardiac adaptations to extreme hemodynamic and metabolic stressors, and comparing such naturally occurring hemodynamics (bear hibernation) to congestive heart failure (dogs).

Current investigations include: Differential regulation of cardiac β-adrenergic receptors and local myocardial adiponectin regulation in hibernating bears (collaboration with WSU Bear Conservation and Education Research Facility) compared to dogs with heart failure. In addition, I am investigating the role of grizzly bears as a reverse translational model of cardiac disease as a result of obesity.

Dr. Nelson is a member scientist -Washington Center for Muscle Biology (WCMB)  

Research in the News-


Selected Publications

Nelson OL, Rourke B. Increase in cardiac myosin heavy-chain (MyHC) alpha protein isoform in hibernating ground squirrels accompany ventricular hypertrophy and prolonged rates of contraction. J Exp Biol,
Johns S, Nelson OL, Gay JM. Left atrial function in cats with left-sided cardiac disease manifesting pleural effusion verses pulmonary edema. JVIM, 2012 Sep-Oct;26(5):1134-9.
Jackson M, Rodgers BD, Luong D, Vang D, Garikipati D, Stanton J, Nelson OL. Cardiac hypertrophy, enhanced stress response, reduced adiposity and sexual dimorphism in aging myostatin null mice. J Endocrin, 2012; 263-275.
Robbins CT, Lopez-Alfaro C, Rode K, Toien O, Nelson OL. Hibernation and seasonal fasting in bears: the energetic costs and consequences for polar bears. J Mammology. 2012; 93(6):1493-1503.
Barrows N, Nelson OL, Robbins CT, Rourke B. Increased cardiac alpha myosin heavy-chain in left atria and decreased myocardial IGF-I expression accompanies hibernation-induced bradycardia in grizzly bears. Physiol Biochem Zool. 2011 Jan-Feb;84(1):1-17.
Maran BA, Meurs KM, Lahmers SM, Nelson OL. Identification of Beta-1 adrenergic receptor polymorphisms in cats. Res Vet Sci, 2012; Aug;93(1):210-2.

Nelson OL, Robbins CT. Cardiac function adaptations in hibernating grizzly bears (Ursus arctos horribilis). J Comp Physiol B 2009 Nov 26. J Comp Physiol B. 2010 Mar;180(3):465-73.

Rodgers BD, Interlichia JP, Garikipati DK, Mamidi R, Chandra M, Nelson OL, Murry CE, Santana LF. Myostatin represses physiological hypertrophy of the heart and excitation-contraction coupling. J Physiol. 2009 Oct 15;587(Pt 20):4873-86.

McGee-Lawrence ME, Wojda SJ, Barlow LN, Drummer TD, Castillo AB, Kennedy O, Condon KW, Auger J, Black HL, Nelson OL, Robbins CT, Donahue SW. Grizzly bears (Ursus arctos horribilis) and black bears (Ursus americanus) prevent trabecular bone loss during disuse (hibernation). Bone. 2009 Dec;45(6):1186-91

Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschpe C, McNabb M, Larson DF, Labeit S, Gotthardt M. Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.Circ Res. 2009 Sep 11;105(6):557-64.

Nelson OL, Robbins CT, Wu Y, Granzier H. Titin isoform switching is a major adaptive response in hibernating grizzly bears. Am J Physiol Heart Circ Physiol 2008 Jul;295(1):H336-71.

Hershey JD, Robbins CT, Nelson OL, Lin DC. Minimal seasonal alterations in the skeletal muscle of captive brown bears. Physiol Biochem Zool. 2008 March/April;81(2):138-147.

Davidson BJ, Paling AC, Lahmers SM, Nelson OL. Disease Association and Clinical Assessment of Feline Pericardial Effusion. J Am Anim Hosp Assoc 2008 44: 5-9.

McGee ME, Maki AJ, Johnson SE, Nelson OL, Robbins CT, Donahue SW. Decreased bone turnover with balanced resorption and formation prevent cortical bone loss during disuse (hibernation) in grizzly bears. Bone. 2008 Feb;42(2):396-404.

Radke M, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, Gotthardt M. Targeted deletion of Titin's N2B region leads to diastolic dysfunction and cardiac atrophy. PNAS 2007;104(9):3444-3449.

Nelson OL, Lahmers S, Schneider T, Thompson P. The use of an implantable cardioverter defibrillator in a boxer dog to control clinical signs of Arrhythmogenic right ventricular cardiomyopathy. J Vet Intern Med 2006;20:1232-1237.

Nelson OL, McEwen MM, Robbins CT, et al. Cardiac function in active and hibernating grizzly bears. J Am Vet Med Assoc 2003;223:1170-1175.


Publications indexed in PubMed

Last Edited: Feb 07, 2013 1:09 PM   

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