College of Veterinary Medicine Home Department of Veterinary Microbiology and Pathology (VMP)
 
CVM HomeCVM Home
About the College of Veterinary MedicineAbout the College of Veterinary Medicine
Academic Information at the College of Veterinary MedicineAcademic Information at the College of Veterinary Medicine
Financial Aid & Scolarships at the College of Veterinary MedicineFinancial Aid & Scolarships at the College of Veterinary Medicine
Graduate Programs at the College of Veterinary MedicineGraduate Programs at the College of Veterinary Medicine
Research Programs at the College of Veterinary MedicineResearch Programs at the College of Veterinary Medicine
Veterinary Teaching HospitalVeterinary Teaching Hospital
Washington Animal Disease Diagnostic LaboratoryWashington Animal Disease Diagnostic Laboratory
Service Units in the College of Veterinary MedicineService Units in the College of Veterinary Medicine
Faculty and Staff at the College of Veterinary MedicineFaculty and Staff at the College of Veterinary Medicine

Printer Friendly Version of this PagePrinter Friendly Version of this Page
An Alphabetized List of PAgesAn Alphabetized List of PAges
  Steve Hines    
Stephen A. Hines, DVM, PhD, DACVP
Professor of Veterinary Microbiology & Pathology
Berger Keatts Distinguished Professor (Excellence in Teaching)

  In recent years, my research has focused on Rhodococcus equi, a gram-positive bacteria that is an important pathogen in horses. R. equi is related to Mycobacterium species, including the agent that causes tuberculosis. Like M. tuberculosis, R. equi replicates within macrophages and produces pyogranulomatous pneumonia. Disease due to R. equi occurs uniquely in foals between 2 and 6 months of age.  Adult horse appear to be immune and provide a model to study what constitutes a successful immune response (i.e. the correlates of immunity and the protective phenotype).

Our work on equine rhodococcal pneumonia has included pulmonary & mucosal immunity, cytotoxic T lymphocytes, DNA vaccines, and developing methods for studying cellular immune responses in horses. Another important aspect of this work is neonatal immunity, since a successful vaccine would probably need to be administered early in life. Currently we are looking at the role of non-traditional, MHC-unrestricted T lymphocytes and hypothesize that these immune cells recognize unique R. equi lipid antigens presented by CD1 molecules.

The long term goal is to contribute to the development of novel vaccines in animals, especially a vaccine that will prevent rhodococcal pneumonia.

I have also worked for some time on Babesia bovis, an Apicomplexan protozoa that significantly limits cattle production in much of the world. Babesia species replicate within erythrocytes and cause a disease resembling malaria.  This research is primarily collaborative now, and I collaborate with Dr. Don Knowles on Babesia equi and B. caballi, which are important protozoal pathogens affected horses.

Publications:  (Pubmed - Hines SA)

 

Education:

  • B.A.: Miami University, Oxford, Ohio; 1977
  • D.V.M.: Ohio State University, Columbus, Ohio;  1981
  • Residency in Anatomic Pathology: University of Florida - Veterinary Medical Teaching Hospital, Gainesville, Florida; 1982-84
  • Ph.D.: University of Florida, Gainesville, Florida; 1989 (Immunology & Infectious Disease)

Clinical Specialty:

  • Diplomate, American College of Veterinary Pathology (DACVP); 1985.

Personal page

Return to faculty list     |     top of page
 

 
 
Revised February 12, 2006     |     Printer Friendly Version

Contact us: webmaster@wsu.edu 509-335-9515 | Accessibility | Copyright | Policies
College of Veterinary Medicine, PO Box 647010, Washington State University, Pullman, WA 99164-7010 USA
Emergency Preparedness & Safety Links