Steve Hines
Stephen A. Hines,
DVM, PhD, DACVP
Professor of Veterinary Microbiology & Pathology
Berger Keatts Distinguished Professor (Excellence in Teaching)
In recent years, my research has focused on
Rhodococcus equi, a
gram-positive bacteria that is an important pathogen in horses.
R.
equi
is related to
Mycobacterium species, including the agent that causes
tuberculosis. Like
M. tuberculosis, R. equi replicates
within macrophages and produces pyogranulomatous pneumonia. Disease due
to
R.
equi occurs
uniquely in foals between 2 and 6 months of age. Adult horse appear to
be
immune and provide a model to study what constitutes a successful
immune
response (i.e. the correlates of immunity and the protective phenotype).
Our work on
equine
rhodococcal pneumonia has included pulmonary & mucosal immunity,
cytotoxic T
lymphocytes, DNA vaccines, and developing methods for studying cellular
immune
responses in horses. Another important aspect of this work is neonatal
immunity, since a successful vaccine would probably need to be
administered
early in life. Currently we are looking at the role of non-traditional,
MHC-unrestricted
T lymphocytes and hypothesize that these immune cells recognize unique
R.
equi
lipid
antigens presented by
CD1
molecules.
The long term goal is to contribute to the development of
novel vaccines in animals, especially a vaccine that will prevent
rhodococcal
pneumonia.
I have also worked for some time on Babesia bovis, an Apicomplexan
protozoa that significantly limits cattle production in much of the
world.
Babesia species replicate within erythrocytes and cause a disease
resembling malaria. This research is primarily collaborative now, and
I
collaborate with Dr. Don Knowles on Babesia equi and B. caballi,
which are important protozoal pathogens affected horses.
(Pubmed - Hines SA)
Education:
- B.A.: Miami University, Oxford, Ohio; 1977
- D.V.M.: Ohio State University, Columbus, Ohio; 1981
- Residency in Anatomic Pathology: University of Florida -
Veterinary
Medical Teaching Hospital, Gainesville, Florida; 1982-84
- Ph.D.: University of Florida, Gainesville, Florida; 1989
(Immunology &
Infectious Disease)
Clinical Specialty:
- Diplomate, American College of Veterinary Pathology (DACVP); 1985.
