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An Alphabetized List of PAgesAn Alphabetized List of PAges
  Program in Vector-borne Diseases

Program objectives: Understand how arthropod-borne pathogens persist and are transmitted with the goal of preventing disease outbreaks

Program accomplishments

  • Development of Anaplasma and Babesia diagnostic tests for national and international use
  • Determination of the role of persistent infection in tick-borne transmission
  • Elucidation of the genetic basis for antigenic variation
  • Identification of mechanisms required for protective immunity
   

 

Program support

  • National Institutes of Health—Institute of Allergy and Infectious Diseases
  • US Department of Agriculture—National Research Initiative
  • The Wellcome Trust
  • US Department of Agriculture—National Science Foundation Microbial Genome Sequencing Program
  • State of Washington Safe Food Initiative
  • US Department of Agriculture—Animal Diseases Research Unit
  • WSU Animal Health Research Center

Highlighted research publications in 2005

Abbott, J.R., G.H. Palmer, K.A. Kegerreis, P. Hetrick, C.J. Howard, J.C. Hope, and W.C. Brown. 2005. Rapid and long-term disappearance of CD4+ T-lymphocyte responses specific for Anaplasma marginale major surface protein-2 (MSP2) in MSP2 vaccinates following challenge with live A. marginale. Journal of Immunology 174:6702-6715.

Berens, S.J., K.A. Brayton, J.B. Molloy, R.E. Bock, A.E. Lew, and T.F. McElwain.  MSA-2 proteins of Babesia bovis vaccine breakthrough isolates contain a unique hypervariable region composed of degenerate repeats.  Infection and Immunity 73:7180-7189, 2005. 

Brayton, K.A., L.S. Kappmeyer, D.R. Herndon, M.J. Dark, D.L. Tibbals, G.H. Palmer, T.C. McGuire and D.P. Knowles Jr.  Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. Proceedings of the National Academy of Sciences.  102: 844-849, 2005.

Futse, J. E., K. A. Brayton, D. P. Knowles, Jr., and G. H. Palmer. Structural basis for segmental gene conversion in generation of Anaplasma marginale outer membrane protein variants.  Molecular Microbiology 57:212-221, 2005.

Lopez, J.E., W.F. Siems, G.H. Palmer, K.A. Brayton, T.C. McGuire, and W.C. Brown. Identification of surface antigens from the St. Maries strain of A. marginale that stimulate an IgG2 response in outer membrane vaccinates.  Infection and Immunity 73:8109-8118, 2005.

Ueti, M.W., G.H. Palmer, L.S. Kappmeyer, M. Statdfield, G.A. Scoles and D.P. Knowles. Ability of the vector tick Boophilus microplus to acquire and transmit Babesia equi following feeding on chronically infected horses with low-level parasitemia. Journal of Clinical Microbiology 43:3755-3759. 2005

*Selected from over 35 program publications in 2005

 

For more information on the Program in Vector-borne diseases, contact Dr. Guy Palmer, Program Leader

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Revised May 05, 2006     |     Printer Friendly Version

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