Program accomplishments

• Improved diagnosis and prevention of immune deficiencies in neonates
• Definition of protective immune responses in ruminants and horses
• Identification of vaccine antigens and epitopes in bacterial, protozoal, helminth, and viral pathogens
• Genomic and proteomic approaches to antigen discovery
• Development of novel adjuvants for enhanced priming of immune responses

Program support

• National Institutes of Health—Institute of Allergy and Infectious Diseases
• US Department of Agriculture—National Research Initiative
• State of Washington Safe Food Initiative
• US Department of Agriculture—Animal Diseases Research Unit
• WSU Animal Health Research Center

Significant research publications in 2002-2005*

Staska LM, Davies CJ, Brown WC, McGuire TC, Suarez CE, Park JY, Mathison BA, Abbott JR, Baszler TV: Vaccine-candidate peptides in the NcSRS2 surface protein of Neospora caninum identified by CD4+ CTL and IFN-g-secreting T lymphocytes of infected Holstein cattle. Infect. Immun. 73: 1321-1329, 2005

Staska LM, McGuire TC, Davies CA, Lewin HA, Baszler TV: Parasite-specific MHC-restricted Killing by Both CD4+ and CD8+ T Lymphocytes in Experimental Bovine Neosporosis. Infect. Immun. 71:3272-3279, 2003

Fraser, D.G., Oaks, J.L., Brown, W.C., and McGuire, T.C. 2002. Identification of broadly-recognized, T helper lymphocyte epitopes in an equine lentivirus. Immunology, 105:295-305.

Mosqueda, J., McElwain, T.F., Stiller, D., and Palmer, G.H. 2002. Babesia bovis merozoite surface antigen-1 and rhoptry associated protein-1 are expressed in sporozoites, and specific antibodies inhibit sporozoite attachment to erythrocytes. Infection and Immunity, 70:1599-1603.

Ridgely, S.L. and McGuire, T.C. 2002. Lipopeptide stimulation of MHC class I-restricted memory cytotoxic T lymphocytes from equine infectious anemia virus-infected horses. Vaccine, 20:1809-1819.

Mwangi, W., Brown, W.C., Lewin, H.A., Howard, C.J., Hope, J.C., Baszler, T.V., Caplazi, P., Abbott, J., and Palmer, G.H. 2002. DNA-encoded fetal liver tyrosine kinase 3 ligand and granulocyte macrophage-colony stimulating factor increase dendritic cell recruitment to the inoculation site and enhance antigen-specific CD4+ T cell responses induced by DNA vaccination of outbred animals. Journal of Immunology, 169:3837-3846.

Lopez, A.M., Hines, M.T., Palmer, G.H., Knowles, D.P., Alperin, D.C., and Hines, S.A. 2003. Analysis of anamnestic immune responses in adult horses and priming in nenates induced by a DNA vaccine expressing the vapA gene of Rhodococcus equi. Vaccine 21:3815-3825.

Zhang, Y., Palmer, G.H., Abbott, J.R., Howard, C.J., Hope, J.C., and Brown, W.C. 2003. CpG ODN 2006 and IL-12 are comparable for priming Th1 lymphocyte and IgG responses in cattle immunized with a rickettsial outer membrane protein in alum. Vaccine 21:3307-3318.

Brown, W.C., Brayton, K.A., Styer, C.M., and Palmer, G.H. 2003. The hypervariable region of Anaplasma marginale major surface protein 2 (MSP2) contains multiple immunodominant CD4+ T lymphocyte epitopes that elicit variant-specific proliferative and IFN- responses in MSP2 vaccinates. Journal of Immunology 170:3790-3798.

*Graduate Students , Veterinary Students, and Post-doctoral trainees in BOLD.

For more information on the Program in Vector-borne diseases, contact Dr Wendy Brown, Program Leader

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