College of Veterinary Medicine

Research in Veterinary Clinical Sciences

Tumor Paint for Solid tumors

Use of a "tumor paint" a bioconjugate composed of the tumor targeting peptide chlorotoxin (Ctx) conjugated to a near infra-red fluorophore to identify tumor tissue- a pilot study

Purpose of Study

The purpose of this study is to determine how the Tumor Paint drug binds to different cancer cells and to assess the Tumor Paint signal in various tumor types.  For many types of cancer, surgery is the primary treatment and the surgeon's ability to remove all of the tumor, and nothing more, is directly related to survival of the patient.  Blaze Bioscience, Inc. is developing a drug called Tumor Paint to "paint" a tumor while it is still in the patient.  This paint allows the surgeon to see the tumor so they can completely remove the cancerous tissue while sparing surrounding healthy tissue.  This technology will be particularly helpful in human brain, prostate and breast cancers.  Since naturally arising dog tumors closely resemble human tumors, this study will focus on dog tumors. 

**Note:  At this time we have completed phase one of this study, thanks to the willing participation of clients at the WSU-VTH, and human trials for Tumor Paint are underway.  We will continue to conduct the dog study and will now focus specifically on soft tissue sarcomas and brain tumors.


Information gained from this trial will lead to further human clinical trials, as well as future studies in dogs, paving the way for new cancer treatments for both humans and dogs.  Enrolled dogs will receive state of the art therapy to remove their solid tumors. Eligible dogs will receive an examination by a board certified oncologist, blood work and urinalysis and at least one overnight stay at no cost.  In addition, they will receive a surgery credit of $500 and discounted anesthesia costs.  (Approximate total discount: $900)

Enrollment Requirements

Enrolled dogs need to have a diagnosed, malignant, solid tumor that can be surgically removed. They must have a life expectancy greater than six weeks and may not have any evidence of metastasis or be pregnant or lactating.  They will need to spend eight hours at the WSU-VTH on injection day and will be required to have blood samples taken at least three times after the Tumor Paint injection. Eligible dogs must also be deemed healthy enough to undergo anesthesia and surgery as surgical removal of the tumor is part of the trial. 

Treatment Methods

Enrolled dogs will be given a physical examination and blood and urine will be collected to make sure they are healthy enough to proceed with the trial.  Once they pass the physical exam, participating dogs will receive an injection of Tumor Paint.  Blood will be drawn at specific time points after the Tumor Paint injection.  Between 24 and 48 hours after injection the dogs will be anesthetized and undergo surgery to have their tumor removed.  Dogs will need to stay in the VTH intensive care unit for normal, post-surgical monitoring until they have recovered enough to go home.

Owner Responsibilities

Owners are responsible for the costs associated with the diagnosis of a tumor and surgery and anesthesia costs beyond the money credited by the study.   Owners are also responsible for the costs of additional hospitalization, medications and procedures associated with unforeseen complications. 

Contact Information

For more information please contact Valorie Wiss, Clinical Studies Coordinator. 

(Office: 509-335-0798, Cell: 509-432-5345 or

Last Edited: Mar 04, 2014 9:42 AM

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