College of Veterinary Medicine

Research in IPN

Jun Xu, Ph.D.

Jun Xu  

Jun Xu, Ph.D.
Assistant Professor
VBR 475
Phone: 509-335-5960
Lab:  509-335-2226

General Research Interest

We study cognition and emotion in mouse models of neurodevelopmental disorders (e.g. mental retardation, autism, and mood disorder). Specifically, we carry out analyses that focus on epigenetic chromatin remodeling which integrates the behavioral impacts of genetics, physiology, and early life experience. These projects examine specific chromatin modifying enzymes and chromatin modifications which regulate gene expression, synaptic morphology, and behavior. At the same time, we search for the causative genes and chromatin remodeling events responsible for behavioral variations between mice of different strains, sexes, ages, or social/physical environment. In these projects, we employ a variety of laboratory techniques such as viral-mediated gene knock-in and knock-out, chromatin immunoprecipation, gene expression array, synaptic/dendritic quantification, and behavioral testing.   

Selected Research Projects

Epigenetic chromatin modification, gene expression, synaptic/dendritic morphology, and behavior in mice
with deletion or repression of the X-linked mental retardation gene JARID1C/SMCX.

Sexually dimorphic and juvenile-onset depression-like behaviors in mice.

Research Support

National Institute of Health

Laboratory Personnel:

Matthew Landowski, Research Technician
Dr. Gengze Wei, Postdoctoral Fellow


Selected Publications

Xu J, Deng X, Watkins R, Disteche CM. (2008) Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.  Journal of Neuroscience 28: 4521-4527.

Xu J, Deng X, Disteche CM. (2008) Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.  PLoS ONE. 3(7): e2553. 

Xu, J. and Disteche, C. (2009) Gene dosage haplo-insufficiency in Turner syndrome. In Gravholt, C.H. (ed), Turner – Know Your Body: an Information Book on Turner Syndrome. Novo Nordisk, UK. 

Kim HS, Sherman DK, Sasaki JY, Xu J, Chu TQ, Ryu C, Suh EM, Graham K, and Shelley E. Taylor SE (2010) Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking.  Proc Natl Acad Sci U S A. 107: 15717-21. 

Kim HS, Sherman DK, Taylor SE, Sasaki JY, Chu TQ, Ryu C, Suh EM, Xu J. (2010) Culture, serotonin receptor polymorphism and locus of attention. Social Cognition and Affective Neuroscience.  5: 212-8.  

Xu J and Andreassi M (2010) Reversible Histone Methylation Regulates Brain Gene Expression and Behavior. Hormones and Behavior [2010 Sept 9. Epub ahead of print] 

Mellios N, Galdzicka M, Ginns E, Rogaev E, Xu J, and Akbarian S. (2010) An estrogen-sensitive microRNA, miR-30b, is expressed at decreased levels in cerebral cortex of female subjects with schizophrenia. Schizophrenia Bulletin [2010 Aug 23. Epub ahead of print]


Last Edited: Feb 27, 2014 1:18 PM   

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