College of Veterinary Medicine

Research in IPN

Kenneth B. Campbell, D.V.M., Ph.D.


  Kenneth B. Campbell, D.V.M., Ph.D.

Professor Emeritus
E-Mail: cvselkbc@vetmed.wsu.edu
Office: McCoy South 106
Phone: (509) 335-8011

I use bioengineering approaches to describe, predict, and explain integrative physiologic functions.  For instance, the heart and blood vessels form a complex system whose operation can only be understood in terms that embrace both dynamic descriptions of the component parts and the manner in which the parts interact. Together, the parts and their interaction create overall system behavior, which cannot be predicted from consideration of parts alone.

An example is the flow of blood through the heart and circulatory system, which depends on three general cardiovascular attributes: 1) the ability of the heart to pump blood, 2) the capacity of the vascular system to receive the blood from the heart, and 3) the capability of the vascular system to return blood to the heart. No one attribute dominates, and all three interact in a nontrivial way to establish the eventual level of cardiovascular blood pumping. A similar sequence of cause-and-effect can be applied to understanding limb movement during muscle contraction. Dynamic features of the muscle interact with dynamic features of the load against which the muscles must work to determine the speed of muscle shortening and force development. Mathematical models and engineering systems analysis play an important role in this work.

Biographical Information

Kenneth B. Campbell, Professor, received a B.S. in animal husbandry in 1963, a D.V.M. in 1968, and a Ph.D. in 1973, all from the University of California at Davis. From 1973 until 1976 he was an assistant professor in the Department of Bioengineering, University of Pennsylvania. He came to W.S.U. in 1976 and is now a professor in IPN and the Program in Bioengineering.

A Human Dimension in the Work of Ken Campbell, by Ken Campbell
First in IPN Human Side of Science Series.

Selected Publications

Campbell, K.B.,  M.V. Razumova, R.D. Kirkpatrick, B.K. Slinker.  Nonlinear myofilament regulatory processes affect frequency-dependent muscle fiber stiffness.  Biophys. J. 81:2278-2296, 2001.

Campbell, K.B.,  M.V. Razumova, R.D. Kirkpatrick, B.K. Slinker.  Myofilament kinetics in isometric twitch dynamics.  Ann. Biomed. Eng. 29:384-405, 2001.

Burattini, R., K.B. Campbell.  Comparative analysis of aortic wave reflection in ferrets and dogs.  Am. J. Physiol. Heart Circ. Physiol 282: H244-H255, 2002.

Campbell, K.B., M. Chandra, R.D. Kirkpatrick, B.K. Slinker, W.C. Hunter. Interpreting cardiac muscle force-length dynamics using a novel functional model.  Am J Physiol Heart Circ Physiol 286: H1535-H1545, 2004.

Campbell, K.B., Y. Wu, A.M. Simpson, R.D. Kirkpatrick, S.G. Shroff, H.L. Granzier and B.K. Slinker.  Dynamic myocardial contractile parameters from left ventricular pressure/volume measurements.  Am J Physiol Heart Circ Physiol 289: H000-H000, 2005.

Campbell, K.B., Y. Wu, A.M. Simpson, R.D. Kirkpatrick, S.G. Shroff, H.L. Granzier and B.K. Slinker. Dynamic myocardial contractile parameters from left ventricular pressure/volume measurements. Am J Physiol Heart Circ Physiol 298: H114-H130, 2005.

Campbell, K.B. and M. Chandra. Functions of stretch activation in heart muscle (invited commentary). J. Gen Physiol 127: 89-94, 2006.

Granzier, H.L. and K.B. Campbell. New insights in the role of cardiac myosin binding protein C as a regulator of cardiac contractility. Circ Res. 99(8):795-797, 2006.

Chandra, M., M.L. Tschirgi, I. Rajapakse, K.B. Campbell. Troponin T modulates the magnitude and the rate by which sarcomere length mediates the recruitment of crossbridges in cardiac muscle. Biophys. J. 90: 2867-2876, 2006.

More Publications

 

Last Edited: Apr 09, 2013 10:09 AM   

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