College of Veterinary Medicine

Research in IPN

Ilia Karatsoreos, Ph.D.

 Ilia Kartsoreos
                   Ilia Karatsoreos

Assistant Professor

Office: VBR rm. 313
WSU Pullman, WA
Phone: 335-4829

Circadian (daily) rhythms are evolutionarily ancient, present in almost all organisms, and regulate nearly every biological process. In our modern industrialized society, we have altered the relationship between our circadian rhythms and the day-night cycle. In many cases we are active long into the night and sleep during the day. In extreme cases, such as shift-workers and trans-meridian air travelers (e.g. jet-lag), overriding circadian rhythms can be more than just a nuisance. Chronically, this can lead to heath problems, including development of the metabolic syndrome, increased risk of heart disease, higher incidences of certain types of cancer, disrupted immune responses, and increased risk of suffering from a major depressive syndrome. Dr. Karatsoreos' current research focuses on the relationship between circadian rhythms and mental and physical health, highlighting how circadian rhythms modulate physiology and behavior, as well as how disrupting them in animal models can produce physiological and behavioral abnormalities that change an animal’s susceptibility to further environmental or psychological stress. It is hoped these models will provide an understanding of how dysregulation of the body’s timing and metabolic systems interact to produce changes in behavior and physiology, and will potentially lead to new clinical interventions to alleviate some of the physical and mental health consequences of our modern lifestyles.

Biographical Information

Ilia Karatsoreos received his B.Sc. in Psychology and Zoology from the University of Toronto in 2001. He earned a Ph.D. in Neuroscience/Psychology from Columbia University in New York City in 2007, where he studied the structure and function of the suprachiasmatic nucleus brain clock, and the effects of gonadal hormones on circadian rhythms, with Rae Silver. Ilia carried out a postdoctoral research fellowship in the lab of Bruce McEwen at The Rockefeller University in New York from 2007-2011, where he explored the organism wide effects of circadian disruption in the context of stress and allostasis. Ilia joined the faculty in the IPN as an Assistant Professor in December 2011. He has held fellowships from both the National Science and Engineering Research Council of Canada, and the Canadian Institutes of Health Research.

Selected Publications

Karatsoreos, I.N. and McEwen, B.S. (2011) Psychobiological Allostasis: Resistance, Resilience and Vulnerability. Trends in Cognitive Science. 15(12): 576-584.

Karatsoreos, I.N., Butler, M.P., LeSauter, J., Silver, R. (2011) Androgen regulation of plasticity in the suprachiasmatic nucleus brain clock. Endocrinology 152: 1970-1978.

Karatsoreos, I.N., Bhagat, S.M., Bloss, E.B., Morrison, J.H., McEwen, B.S. (2011) Disruption of circadian clocks has ramifications for metabolism, brain and behavior. PNAS 108(4):1657-62.

Yuen, E.Y., Liu W., Karatsoreos, I.N., Ren, Y., Feng, J., McEwen, B.S., Yan, Z. (2011) Mechanisms for Acute Stress-Induced Enhancement of Glutamatergic Transmission and Working Memory. Molecular Psychiatry, Feb;16(2):156-70.

Hill, M.N., Karatsoreos, I.N., Hillard, C.J., McEwen, B.S. (2010) Rapid Induction and Steady-State Regulation of Limbic Endocannabinoid Signaling by Glucocorticoid Hormones. Psychoneuroendocrinology. 35(9):1333-8.

Karatsoreos, I.N., Bhagat, S., Bowles, N.P., Weil, Z.M., Pfaff, D.W., McEwen, B.S. (2010) Endocrine and physiological changes in response to chronic corticosterone: A potential model of the metabolic syndrome in mouse. Endocrinology. 151: 2117-2127.

Yuen, E.L., Wenhua, L., Karatsoreos, I.N., Feng, J., McEwen, B.S., Yan Z. (2009) Acute Stress Enhances Glutamatergic Transmission in Prefrontal Cortex and Facilitates Working Memory. Proceedings of the National Academy of Sciences. Aug 18; 106 (33); 14075-79.

Yan, L., Karatsoreos, I., Lesauter J., Welsh D.K., Kay, S., Foley, D., Silver R. (2008) Exploring Spatiotemporal Organization of SCN Circuits. Cold Spring Harbor Symposium on Quantitative Biology. Jan 1; 72:527-541.

Karatsoreos, I.N., Yan, L., LeSauter, J., Silver, R. (2004) Phenotype Matters: Identification of Light Response Cells in Mouse SCN. Journal of Neuroscience, 24 (1): 68-75.

Last Edited: Jul 09, 2013 8:33 AM   

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