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An example is the flow of blood through the heart and circulatory system,
which depends on three
general cardiovascular attributes: 1) the ability of the heart to pump blood, 2) the
capacity of the vascular system to receive the blood from the heart, and 3) the capability
of the vascular system to return blood to the heart. No one attribute dominates, and all
three interact in a nontrivial way to establish the eventual level of cardiovascular blood
pumping. A similar sequence of cause-and-effect can be applied to understanding limb
movement during muscle contraction. Dynamic features of the muscle interact with dynamic
features of the load against which the muscles must work to determine the speed
of muscle shortening and force development. Mathematical models and engineering systems
analysis play an important role in this work.
Biographical Information
Kenneth B. Campbell,
Professor, received a B.S. in animal husbandry in 1963, a D.V.M. in 1968, and
a Ph.D. in 1973, all from the University of California at Davis. From 1973
until 1976 he was an assistant professor in the Department of Bioengineering,
University of Pennsylvania. He came to W.S.U. in 1976 and is now a professor
in the Department of VCAPP and the Program in Bioengineering.
A Human Dimension in the Work of Ken Campbell, by Ken Campbell
First in
the VCAPP
Human Side of Science
Series.
Selected Publications
Campbell, K.B., M.V. Razumova, R.D. Kirkpatrick, B.K. Slinker.
Nonlinear myofilament regulatory processes affect frequency-dependent
muscle fiber stiffness. Biophys. J. 81:2278-2296, 2001.
Campbell, K.B., M.V. Razumova, R.D. Kirkpatrick, B.K. Slinker.
Myofilament kinetics in isometric twitch dynamics.
Ann. Biomed. Eng. 29:384-405, 2001.
Burattini,
R., K.B. Campbell. Comparative analysis of aortic wave
reflection in ferrets and dogs. Am. J.
Physiol. Heart Circ. Physiol
282: H244-H255, 2002.
Campbell,
K.B., M. Chandra, R.D. Kirkpatrick, B.K. Slinker, W.C. Hunter. Interpreting
cardiac muscle force-length dynamics using a novel functional model.
Am J Physiol Heart Circ Physiol
286: H1535-H1545, 2004.
Campbell, K.B., Y. Wu, A.M. Simpson,
R.D. Kirkpatrick, S.G. Shroff, H.L. Granzier and B.K. Slinker. Dynamic myocardial
contractile parameters from left ventricular pressure/volume measurements.
Am J Physiol
Heart Circ Physiol 289:
H000-H000, 2005.
Campbell, K.B., Y.
Wu, A.M. Simpson, R.D. Kirkpatrick, S.G. Shroff, H.L. Granzier and B.K.
Slinker. Dynamic myocardial contractile parameters from left ventricular
pressure/volume measurements. Am J Physiol Heart Circ Physiol 298:
H114-H130, 2005.
Campbell, K.B. and M.
Chandra. Functions of stretch activation in heart muscle (invited
commentary). J. Gen Physiol 127: 89-94, 2006.
Granzier, H.L. and
K.B. Campbell. New
insights in the role of cardiac myosin binding protein C as a regulator of
cardiac contractility. Circ Res. 99(8):795-797, 2006.
Chandra, M., M.L. Tschirgi,
I. Rajapakse, K.B. Campbell. Troponin T
modulates the magnitude and the rate by which sarcomere length mediates the
recruitment of crossbridges in cardiac muscle. Biophys. J. 90:
2867-2876, 2006.
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