Professor Emeritus
E-Mail: cvselkbc@vetmed.wsu.edu
Office: McCoy South 106
Phone: (509) 335-8011
I use bioengineering approaches to describe, predict, and explain
integrative physiologic functions. For instance, the heart and
blood vessels form a complex system whose operation can only be
understood in terms that embrace both dynamic descriptions of the
component parts and the manner in which the parts interact. Together,
the parts and their interaction create overall system behavior, which
cannot be predicted from consideration of parts alone.
An example is the flow of blood through the heart and circulatory
system, which depends on three general cardiovascular attributes: 1) the
ability of the heart to pump blood, 2) the capacity of the vascular
system to receive the blood from the heart, and 3) the capability of the
vascular system to return blood to the heart. No one attribute
dominates, and all three interact in a nontrivial way to establish the
eventual level of cardiovascular blood pumping. A similar sequence of
cause-and-effect can be applied to understanding limb movement during
muscle contraction. Dynamic features of the muscle interact with dynamic
features of the load against which the muscles must work to determine
the speed of muscle shortening and force development. Mathematical
models and engineering systems analysis play an important role in this
work.
Biographical Information
Kenneth B. Campbell, Professor, received a B.S. in animal husbandry
in 1963, a D.V.M. in 1968, and a Ph.D. in 1973, all from the University
of California at Davis. From 1973 until 1976 he was an assistant
professor in the Department of Bioengineering, University of
Pennsylvania. He came to W.S.U. in 1976 and is now a professor in IPN
and the Program in Bioengineering.
A Human Dimension in the Work of Ken Campbell, by Ken Campbell
First in IPN
Human Side of Science Series.
Selected Publications
Campbell, K.B., M.V. Razumova, R.D. Kirkpatrick,
B.K. Slinker.
Nonlinear myofilament regulatory
processes affect frequency-dependent muscle fiber stiffness.
Biophys. J. 81:2278-2296, 2001.
Campbell, K.B., M.V. Razumova, R.D. Kirkpatrick,
B.K. Slinker.
Myofilament kinetics in isometric twitch
dynamics. Ann. Biomed. Eng. 29:384-405, 2001.
Burattini, R., K.B. Campbell. Comparative analysis
of aortic wave reflection in ferrets and dogs. Am. J. Physiol. Heart
Circ. Physiol 282: H244-H255, 2002.
Campbell, K.B., M. Chandra, R.D. Kirkpatrick, B.K.
Slinker, W.C. Hunter. Interpreting cardiac muscle force-length dynamics
using a novel functional model. Am J Physiol Heart Circ Physiol 286:
H1535-H1545, 2004.
Campbell, K.B., Y. Wu, A.M. Simpson, R.D. Kirkpatrick,
S.G. Shroff, H.L. Granzier and B.K. Slinker. Dynamic myocardial
contractile parameters from left ventricular pressure/volume measurements.
Am J Physiol Heart Circ Physiol 289: H000-H000, 2005.
Campbell, K.B., Y. Wu, A.M. Simpson, R.D. Kirkpatrick,
S.G. Shroff, H.L. Granzier and B.K. Slinker. Dynamic myocardial contractile
parameters from left ventricular pressure/volume measurements. Am J Physiol
Heart Circ Physiol 298: H114-H130, 2005.
Campbell, K.B. and M. Chandra. Functions of stretch
activation in heart muscle (invited commentary). J. Gen Physiol 127: 89-94,
2006.
Granzier, H.L. and K.B. Campbell. New insights in the role
of cardiac myosin binding protein C as a regulator of cardiac contractility.
Circ Res. 99(8):795-797, 2006.
Chandra, M., M.L. Tschirgi, I. Rajapakse, K.B. Campbell.
Troponin T modulates the magnitude and the rate by which sarcomere length
mediates the recruitment of crossbridges in cardiac muscle. Biophys. J. 90:
2867-2876, 2006.
