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My laboratory utilizes biochemical,
pharmacological, and behavioral methods to investigate the brain-angiotensin
system. These studies have focused on the membrane receptors for angiotensins,
the enzymatic mechanisms necessary for synthesis and degradation of
angiotensins, and hypertensive animal models that exhibit defects in these
systems.
The most recent work has
focused on the characterization of a new branch of the angiotensin system that
employs the hexapeptide AII(3-8) [AIV] as the signalling agent and unique
membrane-bound receptors.
Biographical Information
Joseph W. Harding,
Professor, completed his B.S in chemistry at Allegheny College in 1970 and
Ph.D. in chemistry at the University of Delaware in 1974. He was a
postdoctoral fellow in neurochemistry with Frank Margolis at Roche Institute
of Molecular Biology in 1974-76 and has been at Washington State University
since 1976.
Selected Publications
Harding, J.W.,
J.W. Wright, G.W. Swanson, J.M Hanesworth and L.T. Krebs. 1994. AT4 receptors: Specificity
and distribution. Kidney International 46: 1510-1512.
Sardinia, M.F., J.M. Hanesworth, R. Krishnan and J.W.
Harding. 1994. AT4 receptor structure-binding relationship: N-terminal modified
angiotensin IV analogs. Peptides 15: 1399-1406.
Wright, J.W., L.A. Stubley, B.A. Mungall and J.W. Harding.
1994. Role of the brain angiotensin system in the control of blood pressure and
hypertension. Asia Pac. J. Pharmacol. (Invited Review Article) 9:219-238.
Roberts, K.A., L.T. Krebs, E. Kramar, M.J. Shaffer, J.W.
Harding and J.W. Wright. 1995. Autoradiographic identification of brain angiotensin IV
binding sites and differential c-fos expression following intracerebroventricular
injection of angiotensin II and IV in rats. Brain Res. 652:13-21.
Chen, S.Y., J.W. Harding and C.D. Barnes. 1996.
Neuropathology of synthetic b-amyloid peptide analogs in vivo. Brain Res. 715:
44-50.
Moeller, I., D.H. Small, G. Reed, J.W. Harding, F.A.O.
Mendelsohn and S.Y. Chai. 1996. Angiotensin IV inhibits neurite outgrowth in cultured
embryonic chicken sympathetic neurons. Brain Res. 725: 61-66.
Most
Recent Publications
Krueger, J.M., F. Obál, Jr., J.W. Harding, J.W. Wright, and
L. Churchill. 2003. Sleep modulation of the expression of plasticity
markers. In: Sleep and Brain Plasticity. P. Maquet, R.
Stickgold, and C. Smith (eds.). Oxford University Press: England;
pp. 363-376.
Wright, J.W., A.J. Masino, J.R. Reichert, G.G. Turner, S.E. Meighan,
P.C. Meighan, and J.W. Harding. 2003. Ethanol-induced
impairment of spatial memory and brain matrix metalloproteinases.
Brain Res. 963: 252-261.
Davis. C.J., J.W. Harding, and J.W. Wright. 2003. Sleep
deprivation-induced deficits in the latency-to-peak induction and
maintenance of long-term potentiation within the CA1 region of the
hippocampus. Brain Res. 973: 293-297.
Wright, J.W., E. Tamura-Myers, W.L. Wilson, B.P. Roques, C. Llorens-Cortes,
R.C. Speth, and J.W. Harding. 2003. Conversion of brain
angiotensin II to angiotensin III is critical for pressor response
in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284:
R725-R733.
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