Research in VCAPP

James M. Krueger, Ph.D.

All Publications

1. Krueger JM.  (1974)  Ph.D. Dissertation:  Binding of L-alanine to a preparation from taste epithelium of the catfish Ictalurus punctatus.

2. Pappenheimer JR, Koski G, Fencl V, Karnovsky ML, Krueger JM.  (1975)  Extraction of sleep-promoting Factor S from cerebrospinal fluid and from brains of sleep-deprived animals.  J Neurophysiol 38: 1299-1311.

3. Krueger JM, Cagan RH.  (1976)  Biochemical studies of taste sensation: binding of L-3(H)-alanine to a sedimentable fraction from catfish barbel epithelium.  J Biol Chem 251: 88-97.

4. Krueger JM, Sokoloff N, Botelho SY.  (1976)  Sialic acid in rabbit lacrimal gland fluid.  Invest Ophthalmol 15: 479-481.

5. Krueger JM, Pappenheimer JR, Karnovsky ML.  (1978)  Sleep-promoting Factor S: purification and properties.  Proc Natl Acad Sci (USA) 75: 5235-5238.

6. Krueger JM, Bacsik J, Garca-Arrars J.  (1980)  Sleep-promoting material from human urine and its relation to Factor S from brain.  Am J Physiol 238: E116-E123.

7. Pappenheimer JR, Krueger JM, Garcia-Arraras J.  (1981)  Properties of sleep-promoting Factor S derived from human urine.  In: Advanced Physiology Science.  Vol 18: Environmental Physiology.  Obl F Jr, Benedec G (eds).

8. Krueger JM, Pappenheimer JR, Karnovsky ML.  (1982)  The composition of sleep-promoting factor isolated from human urine.  J Biol Chem 257: 1664-1669.

9. Krueger JM.  Sleep-promoting Factor S: characterization and analogs.  (1983)  In: Sleep 1982.  Koella WP (ed); Karger; pp 107-109.

10. Krueger JM, Pappenheimer JR, Karnovsky ML.  (1982)  Sleep-promoting effects of muramyl peptides.  Proc Natl Acad Sci (USA) 79: 6102-6106.

11. Krueger JM, Walter J, Karnovsky M, Chedid L, Choay JP, Lefrancier P, Lederer E.  (1984)  Muramyl peptides: variation of somnogenic activity with structure.  J Exp Med 159: 68-76.

12. Krueger JM, Walter J, Dinarello CA, Wolff SM, Chedid L.  (1984)  Sleep-promoting effects of endogenous pyrogen (interleukin-1).  Am J Physiol 246: R994-R999.

13. Chedid L, Bahr GM, Riveau G, Krueger JM.  (1984)  Specific absorption with monoclonal antibodies to muramyl dipeptide of the pyrogenic and somnogenic activities of rabbit monokine.  Proc Natl Acad Sci (USA) 81: 5888-5891.

14. Martin SA, Karnovsky ML, Krueger JM, Pappenheimer JR, Biemann K.  (1984)  Peptidoglycans as promoters of slow-wave sleep.  I. Structure of sleep-promoting factor isolated from human urine.  J Biol Chem 259: 12652-12658.

15. Krueger JM, Karnovsky ML, Martin SL, Pappenheimer JR, Walter J, Biemann K.  (1984)  Peptidoglycans as promoters of slow-wave sleep.  II. Somnogenic and pyrogenic activities of some naturally occurring muramyl peptides; correlations with mass spectrometric structure determination.  J Biol Chem 259: 12659-12662.

16. Krueger JM.  (1985)  Somnogenic activity of muramyl peptides.  Trends Pharmachol Sci 6: 218-221.

17. Krueger JM, Walter J, Levin C.  (1985)  Factor S and related somnogens: an immune theory for slow-wave sleep.  In: Brain Mechanisms of Sleep.  McGinty D, et al (eds); Raven Press; pp 253-276.

18. Krueger JM.  (1985)  Endogenous sleep factors.  In: Sleep: Neurotransmitters and Neuromodulators.  Wauquier A (ed); Raven Press; pp 319-331.

19. Krueger JM.  (1985)  Muramyl peptides and interleukin-1 as promoters of slow wave sleep.  In: Endogenous Sleep Substances and Sleep Regulation.  Inou S, Borbly AA (eds); Japan Scientific Societies Press: Tokyo, JAPAN; pp 181-192.

20. Krueger JM, Walter J, Dinarello CA, Chedid L. (1985)  Induction of slow-wave sleep by interleukin-1.  Progr Leukocyte Biol 2: 161-170.

21. Moldofsky H, Krueger JM, Walter J, Dinarello CA, Lue FA, Quance G, Oreopoulos DG.  (1985)  Sleep-promoting material extracted from peritoneal dialysate of patients with end-stage renal disease and insomnia.  Peritoneal Dialysis Bull 5: 189-193.

22. Krueger JM.  (1985)  Interleukin-1: a promoter of slow-wave sleep.  In: Neuroimmuno-modulation.  Spector NH (Editor-in-Chief); IWGN: Bethesda, MD; pp 99-102.

23. Krueger JM.  (1986)  Muramyl peptide enhancement of slow-wave sleep.  Meth Find Exp Clin Pharmacol 8: 105-110.

24. Krueger JM.  Somnogenic muramyl peptides.  (1986)  In: Biological Properties of Peptidoglycan.  Seidl HP, Schleifer KH (eds); Walter Degruyter & Co: Berlin, GERMANY; pp 329-334.

25. Krueger JM, Shoham S.  (1986)  Homologies between sleep factors and hibernation triggers.  In: Living in the Cold.  Heller HC (ed); Elsevier Scientific Publishing Co: New York, NY; pp 235-244.

26. Krueger JM, Shoham S, Davenne D.  (1986)  Immune modulators as promoters of slow wave sleep.  Clin Neuropharmacol 9: 462-464.

27. Walter J, Davenne D, Shoham S, Dinarello CA, Krueger JM.  (1986)  Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep.  Am J Physiol 250: R96-R103.

28. Silverman DHS, Krueger JM, Karnovsky ML.  (1986)  Specific binding sites for muramyl peptides on murine macrophages.  J Immunol 136: 2195-2201.

29. Dinarello CA, Krueger JM.  (1986)  Induction of interleukin-1 by synthetic and naturally occurring muramyl peptides.  Fed Proc 45: 2545-2548.

30. Krueger JM, Karaszewski JW, Davenne D, Shoham S.  (1986)  Somnogenic muramyl peptides.  Fed Proc 45: 2552-2555.

31. Krueger JM, Kubillus S, Shoham S, Davenne D.  (1986)  Enhancement of slow-wave sleep by endotoxin and lipid A.  Am J Physiol 251: R591-R597.

32. Krueger JM, Karnovsky ML.  (1987)  Sleep and the immune response.  Ann NY Acad Sci 496: 510-516.

33. Rosenthal RS, Krueger JM.  (1987/1988)  Promotion of sleep by gonococcal peptidoglycan fragments: structural requirements for somnogenic activity.  In: Gonococci and Meningococci.  Poolman JT, Zonen HC, Beuvery EC (eds); Kluwer Academic Publishers: Dordrecht; 1988; pp 581-590.  [1987:  Antonie Van Leeuwenhoek 53: 523-32.]

34. Krueger JM, Rosenthal RS, Martin SA, Walter J, Davenne D, Shoham S, Kubillus SL, Biemann K.  (1987)  Bacterial peptidoglycans as modulators of sleep.  I. Anhydro forms of muramyl peptides enhance somnogenic potency.  Brain Res 403: 249-257.

35. Krueger JM, Davenne D, Walter J, Shoham S, Kubillus SL, Rosenthal RS, Martin SA, Biemann K.  (1987)  Bacterial peptidoglycans as modulators of sleep.  II. Effects of muramyl peptides on the structure of rabbit sleep.  Brain Res 403: 258-266.

36. Krueger JM, Dinarello CA, Shoham S, Davenne D, Walter J, Kubillus S.  (1987)  Interferon alpha-2 enhances slow-wave sleep in rabbits.  Int J Immunopharmacol 9: 23-30.

37. Shoham S, Ahokas RA, Blatteis CA, Krueger JM.  (1987)  Effects of muramyl dipeptide on sleep, body temperature and plasma copper after intracerebral ventricular administration.  Brain Res 419: 223-228.

38. Shoham S, Davenne D, Cady AB, Dinarello CA, Krueger JM.  (1987)  Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep.  Am J Physiol 253: R142-R149.

39. Davenne D, Krueger JM.  (1987)  Enhancement of quiet sleep in rabbit neonates by muramyl dipeptide.  Am J Physiol 253: R646-R654.

40. Shoham S, Davenne D, Krueger JM.  (1987)  Muramyl dipeptide, amphetamine, and physostigmine: effects on sleep of rabbits.  Physiol Behav 41: 179-185.

41. Davenne D, Krueger JM.  (1988)  Quiet sleep in neonates is enhanced by muramyl dipeptide.  In: Sleep 1986.  Koella WP, Obl F Jr, Schulz H, Visser P (eds); Gustav Fisher Verlag: New York, NY; pp 178-179.

42. Krueger JM, Toth LA, Cady AB, Johannsen L, Obl F Jr.  (1988)  Immunomodulation and sleep.  In: Sleep Peptides: Basic and Clinical Approaches.  Inou S, Schneider-Helmert D (eds); Japan Scientific Society Press: Tokyo, JAPAN/Springer-Verlag: Berlin, GERMANY; pp 95-129.

43. Johannsen L, Krueger JM.  (1988)  Quantitation of diaminopimelic acid in human urine.  Adv Biosci 68: 445-449.

44. Shoham S, Krueger JM.  (1988)  Muramyl dipeptide-induced sleep and fever: effects of ambient temperature and time of injections.  Am J Physiol 255: R157-R165.

45. Obl F Jr, Alfldi P, Cady AB, Johannsen L, Sry G, Krueger JM.  (1988)  Growth hormone-releasing factor enhances sleep in rats and rabbits.  Am J Physiol 255: R310-R316.

46. Toth LA, Krueger JM.  (1988)  Alteration of sleep in rabbits by Staphylococcus aureus infection.  Infect Immun 56: 1785-1791.

47. Krueger JM, Majde JA, Blatteis CA, Endsley J, Ahokas RA, Cady AB.  (1988)  Polyriboinosinic:polyribocytidylic acid (Poly I:C) enhances rabbit slow-wave sleep.  Am J Physiol 255: R748-R755.

48. Opp MR, Obl F Jr, Krueger JM.  (1988)  Effects of a-MSH on sleep, behavior, and brain temperature: interactions with IL1.  Am J Physiol 255: R914-R922.

49. Krueger JM, Toth LA, Johannsen L, Obl F Jr, Opp MR, Cady AB.  (1988)  Enhancement of mammalian sleep by immune modulators.  In: Advances in Immunopharmacology 4.  Hadden et al (eds); Pergamon Press: New York, NY; pp 55-63.

50. Krueger JM, Johannsen L.  (1988)  Bacterial products, cytokines and sleep.  In: Molecular Mimicry in Health and Disease.  Lernmark S, Dyrberg T, Terenius L, Hkfelt B (eds); Elsevier: Amsterdam, NETHERLANDS; pp 35-46.

51. Walter JS, Meyers P, Krueger JM.  (1989)  Microinjection of interleukin-1 into brain: separation of sleep and fever responses.  Physiol Behav 45: 169-176.

52. Obl F Jr, Opp MR, Cady A, Johannsen L, Alfldi P, Krueger JM.  (1989)  Links between neuroendocrine processes and sleep regulation.  In: Sleep 88.  Koella WP (ed); Fischer: Stttgart, GERMANY; pp 74-76.

53. Opp MR, Obl F Jr, Krueger JM.  (1989)  Alpha-MSH inhibits normal and IL1-induced excess sleep in rabbits.  In: Sleep 88.  Koella WP (ed); Fischer: Stttgart, GERMANY; pp 145-146.

54. Shoham S, Blatteis CM, Krueger JM.  (1989)  Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever.  Brain Res 476: 396-399.

55. Cady AB, Kotani S, Shiba T, Kusumoto S, Krueger JM.  (1989)  Somnogenic activities of synthetic lipid A.  Infect Immun 57: 396-403.

56. Obl F Jr, Opp MR, Cady AB, Johannsen L, Krueger JM.  (1989)  Prolactin, vasoactive intestinal peptide, and peptide histidine methionine elicit selective increases in REM sleep in rabbits.  Brain Res 490: 292-300.

57. Toth LA, Krueger JM.  (1989)  Hematologic effects of exposure to three infective agents in rabbits.  J Am Vet Med Assoc 195: 981-986.

58. Krueger JM, Obl F Jr, Johannsen L, Cady AB, Toth LA.  (1989)  Endogenous slow wave sleep substances.  In: Slow Wave Sleep: Physiological, Pathophysiological and Functional Aspects.  Wauquier A, Dugovic C, Radulovacki M (eds); Raven Press: New York, NY; pp 75-90.

59. Shibata M, Blatteis CM, Krueger JM, Obl F Jr, Opp MR.  (1989)  Pyrogenic, inflammatory, and somnogenic responses to cytokines: differential modes of action.  In: Thermoregulation: Research and Clinical Applications.  Lomax P, et al (eds); Karger: Basel; pp 69-73.

60. Toth LA, Krueger JM.  (1989)  Effects of microbial challenge on sleep in rabbits.  FASEB-J 3: 2062-2066.

61. Krueger JM.  (1989)  No simple slumber.  The Sciences May/June Issue: pp 36-41.

62. Opp MR, Obl F Jr, Cady AB, Johannsen L, Krueger JM.  (1989)  Interleukin-6 is pyrogenic, but not somnogenic.  Physiol Behav 45: 1069-1072.

63. Opp MR, Obl F Jr, Krueger JM.  (1989)  Corticotropin-releasing factor attenuates interleukin 1-induced sleep and fever in rabbits.  Am J Physiol 257: R528-R535.

64. Krueger JM, Obl F Jr, Opp MR, Johannsen L, Cady AB, Toth LA.  (1989)  Immune response modifiers and sleep.  In: Interactions Among Central Nervous System, Neuroendocrine and Immune Systems.  Hadden JW, Masek K, Nistico G (eds); Pythagora Press: Rome, ITALY; pp 323-350.

65. Cady AB, Riveau G, Chedid L, Dinarello CA, Johannsen L, Krueger JM.  (1989)  Interleukin-1-induced sleep and febrile responses differentially altered by a muramyl dipeptide derivative.  Int J Immunopharmac 11: 887-893.

66. Johannsen L, Rosenthal RS, Martin SA, Cady AB, Obl F Jr, Guinand M, Krueger JM.  (1989)  Somnogenic activity of O-acetylated and dimeric muramyl peptides.  Infect Immun 57: 2726-2732.

67. Krueger JM, Johannsen L.  (1989)  Bacterial products, cytokines and sleep.  J Rheumato 16: 52-57.

68. Krueger JM, Obl F Jr, Opp MR, Toth LA, Johannsen L, Cady AB.  (1990)  Somnogenic cytokines and models concerning their effects on sleep.  Yale J Biol Med 63: 157-172.

69. Johannsen L, Toth LA, Rosenthal RS, Opp MR, Obl F Jr, Cady AB, Krueger JM.  (1990)  Somnogenic, pyrogenic, and hematologic effects of bacterial peptidoglycan.  Am J Physiol 259: R182-R186.

70. Toth LA, Krueger JM.  (1990)  Somnogenic, pyrogenic, and hematologic effects of experimental pasteurellosis in rabbits.  Am J Physiol 258: R536-R542.

71. Krueger JM.  (1990)  Somnogenic activity of immune response modifiers.  Trends Pharma Sci 11: 122-126.

72. Krueger JM, Majde JA.  (1990)  Sleep as a host defense: its regulation by microbial products and cytokines.  Clin Immunol Immunopathol 57: 188-199.

73. Krueger JM, Toth LA, Johannsen L, Opp MR. (1990)  Infectious disease and sleep: involvement of neuroendocrine-neuroimmune mechanisms.  Int J Neurosci 51: 359-362.

74. Krueger JM, Obl F Jr, Opp MR, Cady AB, Johannsen L, Toth LA, Majde JA.  (1990)  Putative sleep neuromodulators.  In: Sleep and Biological Rhythms.  Montplaisir J, Godbout R (eds); Oxford Press: New York, NY; pp 163-185.

75. Krueger JM, Obl F Jr, Toth LA, Johannsen L, Cady AB, Opp M.  (1990)  Sleep factors: models concerning their multiple interactions and specificity for sleep.  In: Endogenous Sleep Factors.  Inou S, Krueger JM (eds); SPB Academic Publishing; pp 19-29.

76. Obl F Jr, Opp MR, Sry G, Krueger JM.  (1990)  Endocrine mechanisms in sleep regulation.  In: Endogenous Sleep Factors.  Inou S, Krueger JM (eds); SPB Academic Publishing; pp 109-120.

77. Krueger JM, Obl F Jr, Johannsen L, Opp MR, Toth LA, Cady AB.  (1990)  Endogenous sleep factors: relationships to physiological variables.  In: Sleep and Respiration.  Issa FG, Suratt PM, Remmers JE (eds); Wiley Liss: New York, NY; pp 1-8.  Prog Clin Biol Res 345: 1-8.

78. Krueger JM, Opp MR, Toth LA, Johannsen L, Kaps L.  (1990)  Cytokines and sleep.  In:  Current Topics in Neuroendocrinology; Vol 10: Behavioral Aspects of Neuroendocrinology.  Ganten D, Pfaff D (eds); Springer-Verlag: Berlin, GERMANY; pp 243-261.

79. Opp MR, Obl F Jr, Payne L, Krueger JM.  (1990)  Responsiveness of rats to interleukin-1: effects of monosodium glutamate treatment of neonates.  Physiol Behav 48: 451-457.

80. Obl F Jr, Opp MR, Cady AB, Johannsen L, Postlethwaite AE, Poppleton HM, Seyer JM, Krueger JM.  (1990  Interleukin 1a and an interleukin 1b fragment are somnogenic.  Am J Physiol 259: R439-R446.

81. Opp MR, Krueger JM.  (1990)  IL-6: A pyrogenic cytokine that is not somnogenic.  In: The Physiological and Pathological Effects of Cytokines.  Kluger M, Oppenheim JJ, Dinarello CA, Powanda M (eds); Wiley-Liss, Inc; pp 319-324.

82. Krueger JM, Opp MR, Toth LA, Kaps L.  (1990)  Immune regulation, hormones, and sleep.  In: Sleep 90.  Horne J (ed); Pontenagel Press: Bochum; pp 371-374.

83. Toth LA, Krueger JM.  (1990)  Infectious disease, cytokines and sleep.  In: The Diencephalon and Sleep.  Mancia M (ed); Raven Press: New York, NY; pp 331-341.

84. Opp MR, Obl F Jr, Krueger JM.  (1991)  Interleukin-1 alters rat sleep: temporal and dose-related effects.  Am J Physiol 260: R52-R58.

85. Johannsen L, Wecke J, Obl F Jr, Krueger JM.  (1991)  Macrophages produce somnogenic and pyrogenic muramyl peptides during the digestion of staphylococci.  Am J Physiol 260: R126-R133.

86. Majde JA, Brown RK, Jones MW, Dieffenbach CW, Maitra N, Krueger JM, Cady AB, Smitka CW, Maassab HF.  (1991)  Detection of toxic viral-associated double-stranded RNA (dsRNA) in influenza-infected lung.  Microbial Pathogen 10: 105-115.

87. Opp MR, Krueger JM.  (1991)  Interleukin 1 receptor antagonist blocks interleukin 1-induced sleep and fever.  Am J Physiol 260: R453-R457.

88. Kaps L, Payne l, Obl F Jr, Opp MR, Johannsen L, Krueger JM.  (1991)  Sleep in diabetic rats: effects of interleukin 1.  Am J Physiol 260: R995-R999.

89. Kaps L, Obl F Jr, Farkas I, Payne LC, Sry G, Rubicsek G, Krueger JM.  (1991)  Cholecystokinin promotes sleep and reduces food intake in diabetic rats.  Physiol Behav 50: 417-420.

90. Obl F Jr, Payne L, Kaps L, Opp MR, Krueger JM.  (1991)  Inhibition of growth hormone-releasing hormone suppresses both sleep and growth hormone secretion in the rat.  Brain Res 557: 149-153.

91. Johannsen L, Labischinski H, Krueger JM.  (1991)  Somnogenic activity of pseudomurein in rabbits.  Infection Immunity 59: 2502-2504.

92. Krueger JM, Johannsen L, Toth LA, Opp MR, Kaps L.  (1991)  CNS mechanisms for sleep responses to microbial challenge.  In: Peripheral Signaling of the Brain.  Neural-immune and Cognitive Function.  (Proceedings of the 6th International Symposium on Neuronal Control of Bodily Function: Basic and Clinical Aspects.)  Frederickson RCA, McGaugh JL, Felten DL (eds); Hogrefe & Huber Publishers: Toronto, Quebec, CANADA; pp 179-192.

93. Krueger JM, Toth LA, Obl F Jr, Opp MR, Kimura-Takeuchi M, Kaps L.  (1991)  Infections, cytokines and sleep.  In: Sleep Hormones and Immunological System.  Smirne S (ed); Masson Editor: Milano, ITALY; pp 59-70.

94. Hong L, Johannsen L, Krueger JM.  (1991)  Modulation of human leukocyte antigenDR expression in glioblastoma cells by interferon gamma and other cytokines.  J Neuroimmunol 35: 139-152.

95. Kaps L, Obl F Jr, Opp MR, Johannsen L, Krueger JM.  (1991)  Intraperitoneal injection of cholecystokinin elicits sleep in rabbits.  Physiol Behav 50: 1241-1244.

96. Obl F Jr, Payne L, Opp MR, Kaps L, Alfldi P, Krueger JM.  (1991)  Hypothalamic-releasing hormones in sleep regulation.  In: Sleep Hormones and Immunological System.  Smirne S (ed); Masson Editor: Milano, ITALY; pp 91-98.

97. Krueger JM, Opp MR, Kaps L, Kimura-Takeuchi M, Toth LA.  (1992)  Muramyl peptides and interleukin-1 in sleep regulation.  In: Endocrine and Nutritional Control of Basic Biological Functions.  Murison R (ed); Hogrefe & Huber Publishers: Toronto, Quebec, CANADA; pp 343-349.

98. Opp MR, Krueger JM.  (1992)  Interleukin-1 involvement in the regulation of sleep.  In: Interleukin-1 in the Brain.  Rothwell N, Dantzer R (eds); Manchester University Press: Manchester; pp 151-172.

99. Krueger JM, Kaps L, Opp MR, Obl F Jr.  (1992)  Prostaglandins E2 and D2 have little effect on rabbit sleep.  Physiol Behav 51: 481-485.

100. Payne L, Obl F Jr, Opp MR, Krueger JM.  1992.  Stimulation and inhibition of growth hormone secretion by interleukin-1b: the involvement of growth hormone-releasing hormone.  Neuroendocrinology 56: 118-123.

101. Opp MR, Postlethwaite AE, Seyer JM, Krueger JM.  (1992)  Interleukin 1 receptor antagonist blocks somnogenic and pyrogenic responses to an interleukin 1 fragment.  PNAS 89: 3726-3730.

102. Kaps L, Krueger JM.  (1992)  Tumor necrosis factor-b induces sleep, fever, and anorexia.  Am J Physiol 263: R703-R707.

103. Kaps L, Hong L, Cady AB, Opp MR, Postlethwaite AE, Seyer JM, Krueger JM.  (1992)  Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor-a and TNF-a fragments.  Am J Physiol 263: R708-R715.

104. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM.  (1992)  Influenza virus-induced changes in rabbit sleep and acute phase responses.  Am J Physiol 263: R1115-R1121.

105. Obl F Jr, Payne L, Opp MR, Alfldi P, Kaps L, Krueger JM.  (1992)  Growth hormone-releasing hormone antibodies suppress sleep and prevent enhancement of sleep after sleep deprivation.  Am J Physiol 263: R1078-R1085.

106. Toth LA, Gardiner TW, Krueger JM.  (1992)  Modulation of sleep by cortisone in normal and bacterially infected rabbits.  Am J Physiol 263: R1339-R1346.

107. Payne LC, Krueger JM.  (1992)  Interactions of cytokines with the hypothalamic-pituitary axis.  J Immunother 12: 171-173.

108. Obl F Jr, Kacsh B, Alfldi P, Payne L, Markovic O, Grosvenor C, Krueger JM.  (1992)  Antiserum to prolactin decreases rapid eye movement sleep (REM Sleep) in the male rat.  Physiol Behav 52: 1063-1068.

109. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM.  (1992)  The role of double-stranded RNA in the induction of the acute-phase response in an abortive influenza virus infection model.  J Infect Dis 166: 1266-1275.

110. Hong L, Imeri L, Opp MR, Postlethwaite AE, Seyer JM, Krueger JM.  (1993)  Intercellular adhesion molecule-1 expression induced by interleukin (IL)-1b or an IL-1b fragment is blocked by an IL-1 receptor antagonist and a soluble IL-1 receptor.  J Neuroimmunol 44: 163-170.

111. Toth LA, Tolley EA, Krueger JM.  (1993)  Sleep as a prognostic indicator during infectious disease in rabbits.  Proc Soc Exper Biol Med 203: 179-192.

112. Krueger JM, Obl F Jr.  (1993)  Growth hormone-releasing hormone and interleukin-1 in sleep regulation.  FASEB J 7: 645-652.

113. Krueger JM, Obl F Jr.  (1993)  A neuronal group theory of sleep function.  J Sleep Res 2: 63-69.

114. Imeri L, Opp MR, Krueger JM.  (1993)  An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-induced sleep and fever.  Am J Physiol 265: R907-R913.

115. Krueger JM.  (1993)  Chemistry of sleep, sleep factors.  In:  Encyclopedia of Sleep and Dreaming.  Carskadon M (ed); MacMillian Publishing Company: New York, NY; pp 108-109.

116. Krueger JM, Kaps L, Kimura-Takeuchi M, Opp MR.  (1993)  Somnogenic cytokines: methods and overview.  In:  Methods in Neuroscience; Vol 17, Part B: Neurobiology of Cytokines.  DeSouza ED (ed); Academic Press: Orlando, FL; pp 111-129.

117. Kaps L, Obl F Jr, Krueger JM.  (1993)  Humoral regulation of sleep.  In:  International Review of Neurobiology; Vol 35.  Bradley RJ, Harris RA (eds); Academic Press; pp 131-160.

118. Krueger JM, Opp MR, Kaps L, Obl F Jr.  (1993)  Interleukin-1 in sleep regulation.  In: Sleep-Wakefulness.  Mohan Kumar V, Mallick HN, Nayar U (eds); Wiley Eastern Ltd: New Delhi, INDIA; pp 11-15.

119. Toth LA, Kimura-Takeuchi M, Krueger JM.  (1993)  Hypersomnia during infectious disease.  In:  Sleep-Wakefulness.  Mohan Kuman V, Mallick HN, Nayar U (eds); Wiley Eastern Ltd: New Delhi, INDIA; pp 155-159.

120. Obl F Jr, Fang J, Payne L, Krueger JM.  (1993)  Interactions between interleukin-1 and growth hormone-releasing hormone in promoting sleep.  In:  Environment and Physiology.  Mallick BN, Singh R (eds); Narosa Publishing House: New Delhi, INDIA; pp 180-185.

121. Krueger JM, Toth LA, Shapiro C.  (1993)  Sleep, the immune response and infectious disease.  In: ABC of Sleep Disorders.  BMJ Publishing Group: London, UNITED KINGDOM; pp 55-58.

122. Payne L, Obl F Jr, Krueger JM.  (1993)  Hypothalamic releasing hormones mediating the effects of interleukin-1 on sleep.  J Cell Biochem 53: 309-313.

123. Kaps L, Shibata M, Kimura M, Krueger JM.  (1994)  Inhibition of nitric oxide synthesis suppresses sleep in rabbits.  Am J Physiol 266: R151-R157.

124. Opp MR, Krueger JM.  (1994)  Anti-interleukin-1b reduces sleep and sleep rebound after sleep deprivation in rats.  Am J Physiol 266: R688-R695.

125. Opp MR, Krueger JM.  (1994)  Interleukin-1 is involved in responses to sleep deprivation in the rabbit.  Brain Res 639: 57-65.

126. Johannsen L, Obl F Jr, Kaps L, Kovalzon V, Krueger JM.  (1994)  Somnogenic activity of muramyl peptide-derived immune adjuvants.  Int J Immunopharm 16: 109-116.

127. Toth LA, Tolley EA, Broady R, Blakely B, Krueger JM.  (1994)  Sleep during experimental trypanosomiasis in rabbits.  Proc Soc Exper Med Biol 205: 174-181.

128. Krueger JM, Toth LA, Floyd R, Fang J, Kaps L, Bredow S, Obl F Jr.  (1994)  Sleep, microbes and cytokines.  Neuroimmunomodulation 1: 100-109.

129. Kimura M, Majde JA, Toth LA, Opp MR, Krueger JM.  (1994)  Somnogenic effects of rabbit and human recombinant interferons in rabbits.  Am J Physiol 267: R53-R61.

130. Obl F Jr, Payne L, Kacsh B, Opp MR, Kaps L, Grosvenor CE, Krueger JM.  (1994)  Involvement of prolactin in the REM sleep-promoting activity of systemic vasoactive intestinal peptide (VIP).  Brain Res 645: 143-149.

131. Krueger JM, Toth LA.  (1994)  Cytokines as regulators of sleep.  Ann NY Acad Sci 739: 299-310.

132. Krueger JM, Obl F Jr.  (1994)  Sleep factors.  In: Sleep and Breathing.  Saunders NA, Sullivan CE (eds); Marcel Dekker, Inc: New York, NY; pp 79-112.

133. Krueger JM, Kovalzon VM.  (1994)  Sleep: modern thoughts on an ancient enigma.  Sci Humanity (in Russian); pp 50-57.

134. Kimura M, Toth LA, Agostini H, Cady AB, Majde JA, Krueger JM.  (1994)  Comparison of acute-phase responses induced in rabbits by the lipopolysaccharide of endotoxin and the double-stranded RNA polyriboinosinic:poly-ribocytidylic acid.  Am J Physiol 267: R1596-R1606.

135. Bredow S, Kacsh B, Obl F Jr, Fang J, Krueger JM.  (1994)  Increase of prolactin mRNA in the rat hypothalamus after intracerebroventricular injection of VIP or PACAP.  Brain Res 660: 301-308.

136. Kaps L, Fang J, Krueger JM.  (1994)  Inhibition of nitric oxide synthesis inhibits rat sleep.  Brain Res 664: 189-196.

137. Krueger JM, Toth LA.  (1994)  Cytokines and sleep mechanisms.  In: Advances in Psychoneuroimmunology.  Szelenyi J, Berczi I (eds); Plenum Press: New York, NY; pp 161-172.

138. Krueger JM, Majde JA.  (1994)  Microbial products and cytokines in sleep and fever regulation.  Crit Rev Immunol 14: 355-379.

139. Krueger JM, Obl F Jr.  (1994)  Sleep substances: an unavoidable fact of neurobiology.  World Fed Sleep Res Soc Newslett 3: 10-15.

140. Kovalzon VM, Obl F Jr, Johannsen L, Krueger JM, Andronova TM.  (1994)  The muramyl peptides and sleep.  Sechenov Physiol J (in Russian) 80: 44-50.

141. Krueger JM, Obl F Jr, Kaps L, Fang J.  (1995)  Brain organization and sleep function.  Behav Brain Res 69: 177-185.

142. Obl F Jr, Fang J, Payne LC, Krueger JM.  (1995)  Growth hormone-releasing hormone (GHRH) mediates the sleep promoting activity of interleukin-1 (IL1) in rats.  Neuroendocrinology 61: 559-565.

143. Kaps L, Shibata M, Krueger JM.  (1995)  The role of cytokines in sleep, fever and anorexia.  In: Human Cytokines: Their Role in Disease and Therapy.  Aggarwal BB, Puri RK (eds); Blackwell Scientific Publications, Inc: Cambridge, MA; pp 305-314.

144. Krueger JM.  (1995)  Sleep and the immune system.  Sleep Med Rev Jan/Feb III; pp 1-2.

145. Krueger JM, Karnovsky ML.  (1995)  Sleep as a neuroimmune phenomenon: a brief historical perspective.  Adv Neuroimmunol 5: 5-12.

146. Knefati M, Somogyi C, Kaps L, Bourcier T, Krueger JM.  (1995)  Acidic fibroblast growth factor (FGF), but not basic FGF, induces sleep and fever in rabbits.  Am J Physiol 269: R87-R91.

147. Krueger JM, Majde JA.  (1995)  Cytokines and sleep.  Int Arch Allergy Immunol 106: 97-100.

148. Krueger JM, Takahashi S, Kaps L, Bredow S, Roky R, Fang J, Floyd R, Renegar K, Guha-Thakurta N, Novitsky S, Obl F Jr.  (1995)  Cytokines in sleep regulation.  Adv Neuroimmunol 5: 171-188.

149. Fang J, Payne L, Krueger JM.  (1995)  Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats.  Brain Res 686: 23-28.

150. Roky R, Obl F Jr, Valatx JL, Bredow S, Fang J, Pagano LP, Krueger JM.  (1995)  Prolactin and rapid eye movement sleep.  Sleep 18: 536-542.

151. Takahashi S, Kaps L, Fang J, Krueger JM.  (1995)  Anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits.  Brain Res 690: 241-244.

152. Fang J, Sanborn CK, Renegar KB, Majde JA, Krueger JM.  (1995)  Influenza viral infections enhance sleep in mice.  Proc Soc Exp Med Biol 210: 242-252.

153. Toth LA, Krueger JM.  (1995)  Lighting conditions alter Candida albicans-induced sleep responses.  Am J Physiol 269: R1441-R1447.

154. Takahashi S, Tooley D, Kaps L, Fang J, Seyer JM, Krueger JM.  (1995)  Inhibition of tumor necrosis factor suppresses sleep in rabbits.  Pflgers Arch 431: 155-160.

155. Kaps L, Krueger JM.  (1996)  Interactive effects of cytokines in the brain: sleep, fever and anorexia.  In: The Physiology of Immunity.  Marsh JA, Kendall MD (eds); CRC Press: Boca Raton, FL; pp 157-167.

156. Obl F Jr, Floyd R, Kaps L, Bodosi B, Krueger JM.  (1996)  Effects of systemic GHRH on sleep in intact and hypophysectomized rats.  Am J Physiol 270: E230-E237.

157. Ayers NA, Kaps L, Krueger JM.  (1996)  Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain.  Brain Res 707: 127-130.

158. Kaps L, Obl F Jr, Book AA, Schweitzer JB, Wiley RG, Krueger JM.  (1996)  The effects of immunolesions of nerve growth factor-receptive neurons by 192-IgG saporin on sleep.  Brain Res 712: 53-59.

159. Takahashi S, Kaps L, Seyer JM, Wang Y, Krueger JM.  (1996)  Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits.  NeuroReport 7: 642-646.

160. Fincher EF, Johannsen L, Kaps L, Takahashi S, Krueger JM.  (1996)  Microglia digest Staphylococcus aureus into low molecular weight biologically active compounds.  Am J Physiol 271: R149-R156.

161. Takahashi S, Kaps L, Fang J, Wang Y, Seyer JM, Krueger JM.  (1996)  An interleukin-1 receptor fragment inhibits spontaneous sleep and muramyl dipeptide-induced sleep in rabbits.  Am J Physiol 271: R101-R108.

162. Shibata M, Parfenova H, Zuckerman SL, Seyer JM, Krueger JM, Leffler CW.  (1996)  Interleukin-1b peptides induce cerebral pial arteriolar dilation in anesthetized newborn pigs.  Am J Physiol 270: R1044-R1050.

163. Fang J, Tooley D, Gatewood C, Renegar KB, Majde JA, Krueger JM.  (1996)  Differential effects of total and upper airway influenza viral infection on sleep in mice.  Sleep 19: 337-342.

164. Krueger JM, Takahashi S, Fang J.  (1996)  Cytokines as regulators of sleep.  In: Physiological Basis of Occupational Heath: Stressful Environments.  Shiraki K, Youref MK (eds); SPB Academic Publishing: Amsterdam, NETHERLANDS; pp 267-278.

165. Takahashi S, Kaps L, Krueger JM.  (1996)  A tumor necrosis factor (TNF) receptor fragment attenuates TNF-a and muramyl dipeptide-induced sleep and fever in rabbits.  J Sleep Res 5: 106-114.

166. Fincher EF, Pabst MJ, Krueger JM.  (1996)  Neutrophils but not monocytes or microglia degrade interleukin-1.  Neuroimmunomodulation 3: 82-86.

167. Krueger JM.  (1996)  Cytokine involvement in sleep responses to infection and physiological sleep.  In: Cytokines in the Nervous System.  Rothwell NJ (ed); Landes Publishing: Austin, TX; pp 41-71.

168. Bredow S, Taishi P, Obl F Jr, Guha-Thakurta N, Krueger JM.  (1996)  Hypothalamic growth hormone-releasing hormone (GHRH) mRNA varies across the day in rats.  NeuroReport 7: 2501-2505.

169. Kaps L, Krueger JM.  (1996)  Nitric oxide donors SIN-1 and SNAP promote non-rapid eye movement sleep in rats.  Brain Res Bull 41: 293-298.

170. Zhang J, Obl F Jr, Fang J, Collins BJ, Krueger JM.  (1996)  Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system.  Neurosci Lett 220: 97-100.

171. Krueger JM, Takahashi S.  (1997)  Thermoregulation and sleep: closely linked but separable.  Ann NY Acad Sci 813: 281-286.

172. Krueger JM, Obl F Jr.  (1997)  Sleep regulatory substances.  In: Monographs in Clinical Neuroscience.  Schwartz WJ (ed); Karger: Basel; 15: 175-194.

173. Ayers NA, Kaps L, Krueger JM.  (1997)  The inhibitory effects of Nw-nitro-L-arginine methyl ester on nitric oxide synthase activity vary among brain regions in vivo, but not in vitro.  Neurochem Res 22: 81-86.

174. Takahashi S, Krueger JM.  (1997)  Inhibition of tumor necrosis factor prevents warming-induced sleep responses in rabbits.  Am J Physiol 41: R1325-R1329.

175. Taishi P, Bredow S, Guha-Thakurta N, Obl F Jr, Krueger JM.  (1997)  Diurnal variations of interleukin-1b mRNA and b-actin mRNA in rat brain.  J Neuroimmunol 75: 69-74.

176. Krueger JM, Fang J.  (1997)  Cytokines in sleep regulation.  In:  Sleep and Sleep Disorders: From Molecule to Behavior.  Hayaishi O, Inoue S (eds); Academic Press; pp 261-277.

177. Obl F Jr, Bodosi B, Szilagyi A, Kacsh B, Krueger JM.  (1997)  Antiserum to growth hormone suppresses sleep in the rat.  Neuroendocrinology 66: 9-16.

178. Obl F Jr, Kacsh B, Bredow S, Guha-Thakurta N, Krueger JM.  (1997)  Sleep in rats rendered chronically hyperprolactinemic with anterior pituitary grafts.  Brain Res 755: 130-136.

179. Floyd RA, Krueger JM.  (1997)  Diurnal variations of TNFa in the rat brain.  NeuroReport 8: 915-918.

180. Krueger JM.  (1997)  Sleep and immune function.  Karger Gazette (April) No 61: 6-8.

181. Takahashi S, Fang J, Kaps L, Wang Y, Krueger JM.  (1997)  Inhibition of brain interleukin-1 attenuates sleep rebound after sleep deprivation in rabbits.  Am J Physiol 273: R677-R682.

182. Fang J, Wang Y, Krueger JM.  (1997)  Mice lacking the TNF 55-kD receptor fail to sleep more after TNFa treatment.  J Neurosci 17: 5949-5955.

183. Beranek L, Obl F Jr, Taishi P, Bodosi B, Laczi F, Krueger JM.  (1997)  Changes in rat sleep after single and repeated injections of the long-acting somatostatin analog, octreotide.  Am J Physiol 42: R1484-R1491.

184. Hansen MK, Krueger JM.  (1997)  Subdiaphragmatic vagotomy blocks the sleep and fever-promoting effects of interleukin-1b.  Am J Physiol 273: R1246-R1253.

185. Bredow S, Taishi P, Guha-Thakurta N, Obl F Jr, Krueger JM.  (1997)  Diurnal variations of tumor necrosis factor-a mRNA and a-tubulin mRNA in rat brain.  J NeuroImmunoMod 4: 84-90.

186. Chen Z, Krueger JM.  (1998)  Sleep regulatory substances: changes in mRNA expression linked to sleep.  In: Molecular Regulation of Conscious States.  Lydic R (ed); CRC Press: Boca Raton, FL; pp 33-44.

187. Hansen M, Kaps L, Fang J, Krueger JM.  (1998)  Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats.  Am J Physiol 274: R168-R174.

188. Kaps L, Hansen MK, Chang H-Y, Krueger JM.  (1998)  Vagotomy attenuates but does not prevent somnogenic and febrile effects of lipopolysaccharide in rats.  Am J Physiol 274: R406-R411.

189. F ang J, Wang Y, Krueger JM.  (1998)  The effects of interleukin-1b on sleep are mediated by the type I receptor.  Am J Physiol 274: R655-R660.

190. Renegar KB, Floyd R, Krueger JM.  (1998)  Effect of sleep deprivation on serum influenza-specific IgG.  Sleep 21: 19-24.

191. Kimura M, Kaps L, Krueger JM.  (1998)  Oxidized glutathione promotes sleep in rabbits.  Brain Res Bull 45: 545-548.

192. Obl F Jr, Kaps L, Bodosi B, Krueger JM.  (1998)  Changes in sleep in response to intracerebral injection of insulin-like growth factor-1 (IGF-1) in the rat.  Sleep Res Online 2: 87-91.

193. Hansen MK, Taishi P, Chen Z, Krueger JM.  (1998)  Vagotomy blocks the induction of interleukin-1b mRNA in the brain of rats in response to systemic interleukin-1b.  J Neurosci 18: 2247-2253.

194. Kushikata T, Takahashi S, Wang Y, Fang J, Krueger JM.  (1998)  An interleukin-1 receptor fragment blocks ambient temperature-induced increases in brain temperature but not sleep in rabbits.  Neurosci Lett 244: 125-128.

195. Hansen MK, Taishi P, Chen Z, Krueger JM.  (1998)  Cafeteria-feeding induces interleukin-1b mRNA expression in rat liver and brain.  Am J Physiol 43: R1734-R1739.

196. Renegar KB, Floyd RA, Krueger JM.  (1998)  Effects of short-term sleep deprivation on murine immunity to influenza virus in young adult and senescent mice.  Sleep 21: 241-248.

197. Krueger JM, Fang J, Hansen MK, Zhang J, Obl F Jr.  (1998)  Humoral regulation of sleep.  News Physiol Sci 13: 189-194.

198. Kushikata T, Fang J, Chen Z, Wang Y, Krueger JM.  (1998)  Epidermal growth factor (EGF) enhances spontaneous sleep in rabbits.  Am J Physiol 275: R509-R514.

199. Obl F Jr, Kaps L, Krueger JM.  (1998)  Albumin enhances sleep in the young rat.  Physiol Behav 64: 261-266.

200. Hansen MK, Krueger JM.  (1998)  Subdiaphragmatic vagotomy does not block sleep deprivation-induced sleep in rats.  Physiol Behav 64: 361-365.

201. Taishi P, Chen Z, Obl F Jr, Zhang J, Hansen M, Fang J, Krueger JM.  (1998)  Sleep-associated changes in interleukin-1b mRNA in the brain.  J Interferon Cytokine Res 18: 793-798.

202. Krueger JM, Fang J, Taishi P, Chen Z, Kashikata T, Gardi J.  (1998)  Sleep: a physiological role for IL1b and TNFa.  Ann NY Acad Sci 856: 148-159.

203. Kushikata T, Fang J, Wang Y, Krueger JM.  ( 1998)  Interleukin-4 inhibits spontaneous sleep in rabbits.  Am J Physiol 275: R1185-R1191.

204. Krueger JM.  (1998)  Animal models of sleep.  J Musculoskeletal Pain 6: 87-92.

205. Majde JA, Guha-Thakurta N, Chen Z, Bredow S, Krueger JM.  (1998)  Spontaneous release of stable viral double-stranded RNA into the extracellular medium by influenza virus-infected MDCK epithelial cells: implications for the viral acute phase response.  Arch Virol 143: 2371-2380.

206. Zhang J, Chen Z, Taishi P, Obl F Jr, Fang J, Krueger JM.  (1998)  Sleep deprivation increases rat hypothalamic growth hormone-releasing hormone mRNA.  Am J Physiol 275: R1755-R1761.

207. Krueger JM, Fang J.  (1999)  Cytokines and sleep regulation.  In:  Handbook of Behavioral State Control.  Lydic R, Baghdoyan HA (eds); CRC Press: Boca Raton, FL; pp 609-622.

208. Fang J, Bredow S, Taishi P, Majde JA, Krueger JM.  (1999)  Synthetic influenza viral double-stranded RNA induces an acute phase response in rabbits.  J Med Virol 57: 198-203.

209. Zhang J, Obl F Jr, Zheng T, Fang J, Taishi P, Krueger JM.  (1999)  Intrapreoptic microinjection of GHRH or its antagonist alters sleep in rats.  J Neurosci 19: 2187-2194.

210. Obl F Jr, Krueger JM.  (1999)  Hormones and REM sleep.  In: Rapid Eye Movement Sleep.  Mallick BN, Inoue S (eds); Narosa Publishers: New Delhi, INDIA; pp 233-247.

211. Takahashi S, Kaps L, Fang J, Krueger JM.  (1999)  Somnogenic relationships between tumor necrosis factor and interleukin-1.  Am J Physiol 276: R1132-R1140.

212. Kushikata T, Fang J, Krueger JM.  (1999)  Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits.  Am J Physiol 276: R1334-1338.

213. Takahashi S, Krueger JM.  (1999)  Nerve growth factor enhances sleep in rabbits.  Neurosci Lett 264: 149-152.
     

214. Krueger JM, Floyd RA, Fang J.  (1999)  Relationships between sleep and immune function.  In: Regulation of Sleep and Circadian Rhythms.  Turek FW, Zee PC (eds); Marcel Dekker, Inc: New York, NY; pp 427-464.

215. Chen Z, Gardi J, Kushikata T, Fang J, Krueger JM.  (1999)  Nuclear factor kappa B-like activity increases in murine cerebral cortex after sleep deprivation.  Am J Physiol 45: R1812-R1818.

216. Krueger JM, Obl F Jr, Fang J.  (1999)  Humoral regulation of physiological sleep; cytokines and GHRH.  J Sleep Res 8(Supp 1): 53-59.

217. Obl F Jr, Kaps L, Gardi J, Taishi P, Bodosi B, Krueger JM.  (1999)  Insulin-like growth factor-1 (IGF-1) induced inhibition of growth hormone secretion is associated with sleep suppression.  Brain Res 818: 267-274.

218. Krueger JM, Obl F Jr, Fang J.  (1999)  Why we sleep.  Sleep Med Rev 3: 119-129.
     

219. Obl F Jr, Krueger JM.  (2000)  Hormones, cytokines and sleep.  In: Coping with the Environment Neural and Endocrine Mechanisms: Handbook of Physiology.  McEwen BS (ed); Oxford University Press; Chapter 16, pp 331-349.

220. Krueger JM, Fang J.  (2000)  Sleep and host defense.  In: Principles and Practice of Sleep Medicine; 3rd edition.  Kryger MH, Roth T, Dement W (eds); WB Saunders Co: Orlando, FL; pp 255-265.

221. Krueger JM.  (1998)  Neurochemistry of sleep regulation.  Le Cahiers du Mdecin 13: 14-15.

222. Pabst MJ, Beranova S, Krueger JM.  (1999)  A review of the effects of muramyl peptides on macrophages, monokines and sleep.  Neuroimmunomodulation 6: 261-283.

223. Kushikata T, Fang F, Krueger JM.  (1999)  Interleukin-10 inhibits spontaneous sleep in rabbits.  J Interferon Cytokine Res 19: 1025-1030.

224. Hansen MK, Krueger JM.  (1999)  Kupffer cell depletion with gadolinium chloride prevents cafeteria diet-induced sleep in rats.  Sleep 22: 707-715.

225. Roky R, Kaps L, Taishi P, Fang J, Krueger JM.  (1999)  Food restriction alters the diurnal distribution of sleep in rats.  Physiol Behav 67: 697-703.

226. Gardi J, Obl F Jr, Fang J, Zhang J, Krueger JM.  (1999)  Diurnal variations and sleep-deprivation-induced changes in rat hypothalamic GHRH and somatostatin contents.  Am J Physiol 46: R1339-R1344.

227. Beranek L, Hajdu I, Gardi J, Taishi P, Obl F Jr, Krueger JM.  (1999)  Central administration of the somatostatin analog octreotide induces captopril-insensitive sleep responses.  Am J Physiol 46: R1297-R1304.

228. Krueger JM, Fang J, Obl F Jr.  (2000)  La solitude nocturne des neurons.  La Recherche A3, April; pp 26-27.
     

229. Krueger JM.  (2000)  Cytokines and growth factors in sleep regulation.  In: HFSP Workshop 8: The Regulation of Sleep; pp 122-131.

230. Krueger JM, Fang J, Majde JA.  (2001)  Sleep in health and disease.  In: Psychoneuroimmunology, 3rd edition.  Ader B, Felton D, Cohen N (eds); Academic Press; pp 667-685.

231. Hajdu I, Obl F Jr, Gardi J, Laczi F, Krueger JM.  (2000)  Octreotide-induced drinking, vasopressin and pressure responses: involvement of central angiotensin and acetylcholine.  Am J Physiol 279: R271-R277.
     

232. Kubota T, Kushikata T, Fang J, Krueger JM.  (2000)  A nuclear factor kappa b (NFkB) inhibitor peptide inhibits spontaneous and interleukin-1b-induced sleep.  Am J Physiol 279: R404-R413.
     

233. Kubota T, Fang J, Kushikata T, Krueger JM.  (2000)  Interleukin 13 and transforming growth factor-b1 inhibit spontaneous sleep in rabbits.  Am J Physiol 279: R786-R792.
     

234. Bodosi B, Obl F Jr, Gardi J, Komldi J, Krueger JM.  (2000)  Ether stress induces increases in REM sleep in the rat: possible role of prolactin.  Am J Physiol 279: R1590-R1598.
     

235. Krueger JM, Obl F Jr, Fang J, Kubota T, Taishi P.  (2001)  The role of cytokines in sleep regulation.  Ann NY Acad Sci 933: 211-221.
     

236. Renegar KB, Crouse D, Floyd RA, Krueger JM.  (2000)  Progression of influenza viral infection through the respiratory tract: the protective role of short-term sleep-deprivation.  Sleep 23: 859-863.

237. Rehman A, Taishi P, Fang J, Majde JA, Krueger JM.  (2001)  The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation.  Cytokine 13: 8-17.
     

238. Kubota T, Fang J, Guan Z, Brown RA, Krueger JM.  (2001)  Vagotomy attenuates tumor necrosis factor-a induced sleep and EEG delta activity.  Am J Physiol 280: R1213-1220.
     

239. Kushikata T, Kubota T, Fang J, Krueger JM.  (2001)  Glial cell line-derived neurotrophic factor (GDNF) promotes sleep in rats and rabbits.  Am J Physiol 280: R1001-R1006.
     

240. Obl F Jr, Fang J, Taishi P, Kacsh B, Gardi J, Krueger JM.  (2001)  Deficiency of growth hormone-releasing hormone signaling is associated with sleep alterations in the dwarf rat.  J Neurosci 21: 2912-2918.
     

241. Churchill L, Taishi P, Guan Z, Chen L, Fang J, Krueger JM.  (2001)  Sleep modifies glutamate decarboxylase mRNA within the barrel cortex of rats after a mystacial whisker trim.  Sleep 24: 261-266.
     

242. Brandt J, Churchill L, Guan Z, Fang J, Chen L, Krueger JM.  (2001)  Sleep deprivation, but not a whisker trim, increases nerve growth factor within barrel cortical neurons.  Brain Res 898: 105-112.
     

243. Obl F Jr, Krueger JM.  (2001)  The somatotropic axis and sleep.  Revue Neurologique 157: 5512-5515.
     

244. Krueger JM, Obl F Jr.  (2002)  Function of sleep.  In: Sleep Medicine.  Lee-Choing T, Carskadon M, Sateia M (eds); Hanley & Belfus, Inc: Philadelphia, PA; pp 23-30.
     

245. Majde JA, Krueger JM.  Neuroimmunology of sleep.  (2002)  In: Textbook of Biological Psychiatry.  Dhaenen H, den Boer JA, Westenberg H, Willner P (eds); John Wiley & Sons, Ltd: London, UNITED KINGDOM; Chapter 24-4, pp 1247-1257.
     

246. Taishi P, Sanchez C, Wang Y, Fang J, Harding JW, Krueger JM.  (2001)  Conditions that affect sleep alter the expression of molecules associated with synaptic plasticity.  Am J Physiol 281: R839-R845.
     

247. Kubota T, Brown RA, Fang J, Krueger JM.  (2001)  Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits.  Am J Physiol 281: R1004-R1012.
     

248. Kubota T, Fang J, Brown RA, Krueger JM.  (2001)  Interleukin-18 promotes sleep in rabbits and rats.  Am J Physiol 281: R828-R838.
     

249. Kubota T, Majde JA, Brown RA, Krueger JM.  (2001)  Tumor necrosis factor receptor fragment attenuates interferon-g-induced non-REM sleep in rabbits.  J Neuroimmunol 119: 192-198.
     

250. Gardi J, Krueger JM, Speth RC.  (2001)  Preparation and a simple one-step purification of [His1-mono-125I-tyr10, Nle27]-hGHRH (1-32)-NH2.  J Labeled Compounds Radiopharm 44: 1-6.
     

251. Kubota T, Fang J, Meltzer LT, Krueger JM.  (2001)  Pregabalin enhances non-REM sleep.  J Pharm Exp Ther 299: 1095-1105.
     

252. Hajdu I, Obl F Jr, Fang J, Krueger JM, Rollo CD.  (2002)  Sleep of transgenic mice producing excess rat growth hormone.  Am J Physiol 282: R70-R76.
     

253. Gardi J, Szentirmai , Hajdu I, Obl F Jr, Krueger JM.  (2001)  The somatostatin analog, octreotide, inhibits GHRH and stimulates angiotensin release in the rat hypothalamus.  Neurosci Lett 315: 37-40.
     

254. Kubota T, Li N, Z Guan, Brown R, Krueger JM.  (2002)  Intrapreoptic microinjection of TNFa enhances non-REM sleep in rats.  Brain Res 932: 37-44.
     

255. Krueger JM, Obl F Jr, Harding JW, Wright JW, Churchill L.  (2003)  Sleep modulation of the expression of plasticity markers.  In: Sleep and Brain Plasticity.  Maquet P, Stickgold R, Smith C (eds); Oxford University Press: Oxford, UNITED KINGDOM; pp 363-376.

256. Kubota T, De A, Brown RA, Simasko SM, Krueger JM.  (2002)  Diurnal effects of acute and chronic administration of ethanol on sleep in rats.  Alcohol Clin Exp Res 26: 1153-1161.

257. Gardi J, Speth RC, Taishi P, Kacsh B, Obl F Jr, Krueger JM.  (2002)  Alterations in GHRH binding in the pituitary of adult dw/dw rats.  Peptides 23: 1497-1502.

258. Gardi J, Taishi P, Speth RC, Obl F Jr, Krueger JM.  (2002)  Sleep loss alters hypothalamic growth hormone-releasing hormone receptors.  Neurosci Lett 320: 69-72.

259. Krueger JM, Churchill L.  Cytokines in sleep regulation.  (2003)  In: Cytokine and Mental Health.  Krontol A (ed); Kluwer Academic Publishers: New York, NY; pp 147-166.
     

260. De A, Churchill L, Obl F Jr, Simasko SM, Krueger JM.  (2002)  GHRH and IL1b increase cytoplasmic Ca2+ levels in cultured hypothalamic GABAergic neurons.  Brain Res 949: 209-212.

261. Obl F Jr, Alt J, Taishi P, Gardi J, Krueger JM.  (2003)  Sleep in mice with non-functional growth hormone (GH)-releasing hormone (GHRH) receptors.  Am J Physiol 284: R131-R139.

262. Krueger JM, JA Majde, Obl F Jr.  (2003)  Sleep in host defense.  Brain Behav Immunity 17: S41-S47.

263. Obl F Jr, Krueger JM.  (2003)  Biochemical regulation of sleep.  Frontiers Biosci 8: 520-550.

264. Krueger JM, Obl F Jr.  (2003)  Sleep function.  Frontiers Biosci 8: 511-519.

265. Krueger JM, Majde JA.  (2003)  Humoral links between sleep and the immune system Research Issues.  Ann NY Acad Sci 992: 9-20.

266. Alt J, Obl F Jr, Traynor TR, Gardi J, Majde JA, Krueger JM.  (2003)  Sleep responses to influenza viral infection in GHRH-receptor deficient mice.  J Appl Physiol 95: 460-468.

267. Obl F Jr, Garcia-Garcia F, Krueger JM.  (2005)  The role of endogenous sleep promoting substances.  In:  Sleep Deprivation: Clinical Issues.  Kushida CA (ed); Marcel-Dekker, Inc; pp 515-538.

268. Chen L, Majde JA, Krueger JM.  (2003)  Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes.  Brain Res 973: 214-222.

269. Yoshida H, Kubota T, Krueger JM.  (2003)  A cyclooxygenase-2 inhibitor attenuates spontaneous and TNFa-induced non-rapid eye movement sleep in rabbits.  Am J Physiol 285: R99-R109.

270. De A, Krueger JM, Simasko SM.  (2003)  Tumor necrosis factor a increases cytosolic Ca++ responses to AMPA and KCl in primary cultures of rat hippocampal neurons.  Brain Res 981: 133-142.

271. Kushikata T, Kubota T, Fang J, Krueger JM.  (2003)  Neurotrophin 3 and 4 enhance spontaneous sleep in rabbits.  Neurosci Lett 346: 161-164.

272. Garcia-Garcia F, Krueger JM.  (2003)  Intracerebroventricular injection of erythropoietin enhances sleep in the rat.  Brain Res Bull 61: 541-546.

273. Cearley C, Churchill L, Krueger JM.  (2003)  Time of day differences in IL1b and TNFa mRNA levels in specific regions of brain.  Neurosci Lett 352: 64-66.

274. Hajdu I, Szentirmai , Obl F Jr, Krueger JM.  (2003)  Different brain structures mediate drinking and sleep suppression elicited by the somatostatin analog, octreotide, in rats.  Brain Res 994: 115-123.

275. Krueger JM, Majde JA.  (2005)  Host Defense.  In:  Principles and Practice of Sleep Medicine; 4th Edition.  Kryger M (Editor-in-Chief); Elsevier Science: Philadelphia, PA; pp 256-265.

276. Peterfi Z, Churchill L, Hajdu I, Obl F Jr, Krueger JM, Parducz A.  (2004)  Fos-immunoreactivity in the hypothalamus: dependency on the diurnal rhythm, sleep, gender and estrogen.  Neuroscience 124: 695-707.

277. Taishi P, De A, Alt J, Gardi J, Obl F Jr, Krueger JM.  (2004)  Interleukin-1b stimulates GHRH receptor mRNA expression in the rat hypothalamus in vitro and in vivo.  J Neuroendocrinol 16: 113-118.

278. Traynor TR, Majde JA, Bohnet SG, Krueger JM.  (2004)  Intratracheal double-stranded RNA plus interferon-g: a model for analysis of the acute phase response to respiratory viral infections.  Life Sci 74: 2563-2576.

279. Churchill L, Krueger JM.  (2003)  Growth factors in sleep regulation and neural connectivity: implications for sleep function.  Rec Res Dev Physiol 1: 819-843.

280. Brandt JA, Churchill L, Rehman A, Ellis G, Mmet S, Isral A, Krueger JM.  (2004)  Sleep-deprivation increases activation of nuclear factor kappa B in lateral hypothalamic cells.  Brain Res 1004: 91-97.

281. Garcia-Garcia F, Yoshida H, Krueger JM.  (2004)  Interleukin-8 promotes sleep in rabbits and rats.  J Sleep Res 13: 55-61.

282. Chen L, Taishi P, Majde JA, Peterfi Z, Obl F Jr, Krueger JM.  (2004)  The role of nitric oxide synthases in the sleep response to tumor necrosis factor a.  Brain Behav Immun 18: 390-398.

283. Wright JW, Alt J, Turner GD, Krueger JM.  (2004)  Differences in spatial learning comparing transgenic p75 knockout New Zealand Black, C57BL/6 and Swiss Webster mice.  Behav Brain Res 153: 453-458.

284. Chen L, Duricka D, Nelson S, Mukherjee S, Bohnet SG, Taishi P, Majde JA, Krueger JM.  (2004)  Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases.  J Appl Physiol 97: 17-28.

285. Yoshida H, Peterfi Z, Garcia-Garcia F, Kirkpatrick R, Yasuda T, Krueger JM.  (2004)  State-specific asymmetries EEG in slow wave sleep induced by local application of TNFa.  Brain Res 1009: 129-136.

286. Obl F Jr, Krueger JM.  (2004)  GHRH and sleep.  Sleep Med Rev 8: 367-377.

287. Chen L, Taishi P, Duricka D, Krueger JM.  (2004)  Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity.  Mol Brain Res 129: 179-184.

288. Nelson SE, Duricka D, Campbell KB, Churchill L, Krueger JM.  (2004)  Homer 1a and 1bc levels in the rat somatosensory cortex vary with the time of day and sleep loss.  Neurosci Lett 367: 105-108.

289. Obl F Jr, Krueger JM.  Humoral mechanisms of sleep.  (2005)  In:  The Physiological Nature of Sleep.  Parmeggiani PL, Velluti R (eds); Imperial College Press; pp 23-44.

290. Bodosi B, Gardi J, Hajdu I, Szentirmai , Obl F Jr, Krueger JM.  (2004)  Rhythms of ghrelin, leptin and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation.  Am J Physiol 287: R1071-R1079.

291. Bohnet S, Traynor TR, Majde JA, Kacsh B, Krueger JM.  (2004)  Mice deficient in the interferon type I receptor have reduced REM sleep and altered hypothalamic orexin, prolactin and 2,5-oligoadenylate synthetase expression.  Brain Res 1027: 117-125.

292. Krueger JM, Majde JA.  (2006)  Sleep and the immune response.  In:  A Comprehensive Handbook of Sleep Medicine.  Lee-Chiong TL (ed); John Wiley & Sons, Inc: Hoboken, NJ; pp 767-772.

293. Yasuda T, Yoshida H, Garcia-Garcia F, Kay D, Krueger JM.  (2005)  Interleukin-1b has a role in cerebral cortical state dependent electroencephalographic slow-wave activity.  Sleep 28: 177-184.

294.  Garcia-Garcia F, Ponce S, Brown R, Cussen V, Krueger JM.  (2005)  Sleep disturbances in the rotenone-animal model of Parkinson Disease.  Brain Res 1042: 160-168.

295. Tang C, Sula MJ, Bohnet S, Rehman A, Taishi P, Krueger JM.  (2005)  Interleukin-1b induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP.  Mol Brain Res 137: 213-222.

296. Krueger JM.  (2005)  Mechanisms underlying the central effects of cytokines.  In:  Neuroimmune Mechanisms and Chronic Fatigue Syndrome.  NIH Publication No 04-5497, pp 63-70.

297. Alt J, Bohnet S, Taishi P, Duricka D, Obl F Jr, Traynor T, Majde JA, Krueger JM.  (2005)  Influenza virus-induced glucocorticoid and hypothalamic cytokine mRNA responses in dwarf Lit/Lit mice.  Brain Behav Immun 21: 60-67.

298. Churchill L, Yasuda K, Yasuda T, Blindheim K, Falter M, Garcia-Garcia F, Krueger JM.  (2005)  Unilateral cortical application of tumor necrosis factor a induces asymmetry in Fos- and interleukin-1b immunoreactive cells within the corticothalamic projection.  Brain Res 1055: 15-24.

299. De A, Krueger JM, Simasko SM.  (2005)  Expression and release of glutamate-induced TNFa in cultured hypothalamic cells.  Brain Res 1053: 54-61.

300. Yasuda T, Yasuda K, Brown R, Krueger JM.  (2005)  State-dependent effects of the light/dark cycle on the somatosensory and the visual cortex EEG in rats.  Am J Physiol 289: R1083-R1089.

301. Traynor T, Majde JA, Bohnet S, Krueger JM.  (2006)  Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-deficient mice.  Brain Behav Immunity 20: 290-299.

302. Majde JA, Krueger JM.  (2005)  Links between the innate immune system and sleep.  J Allergy Clin Immunol 116: 1188-1198.

303. Kushikata T, Fang J, Krueger JM.  (2006)  Platelet activating factor and its metabolite promote sleep in rabbits.  Neurosci Lett 394: 233-238.

304. Obl F Jr, Garcia-Garcia F, Kacsh B, Taishi P, Bohnet S, Horseman ND, Krueger JM.  (2005)  REM sleep is reduced in prolactin deficient mice.  J Neurosci 25: 10282-10289.

305. Alfoldi P, Kaps L, Szentirmai , Taishi P, Gardi J, Peterfi Z, Kacsh B, Krueger JM.  (2006)  The somatotropic axis in sleep and thermo regulation.  J Thermal Biol 31: 30-39.

306. Krueger JM, Majde JA, Rector DM.  Cytokines in immune function and sleep regulation.  Handbook of Clinical Neurology.  (In press)

307. Szentirmai , Hajdu I, Obl F Jr, Krueger JM.  (2006)  Ghrelin-induced sleep responses in ad libitum fed and food restricted rats.  Brain Res 1088: 131-140.

308. Szentirmai , Krueger JM.  (2006)  Central administration of neuropeptides Y induces wakefulness in rats.  Am J Physiol 291: R473-R480.

309. Davis CJ, Meighan PC, Taishi P, Krueger JM, Harding JW, Wright JW.  (2006)  REM sleep deprivation attenuates actin-binding protein cortactin: a link between sleep and hippocampal plasticity.  Neurosci Lett 400: 191-196.

310. Peterfi Z, Obl F Jr, Taishi P, Gardi J, Kacsh B, Unterman T, Krueger JM.  (2006)  Sleep in spontaneous dwarf rats.  Brain Res 1108: 133-146.

311. Szentirmai , Krueger JM.  (2006)  Obestatin alters sleep in rats.  Neurosci Lett 404: 222-226.

312. Krueger JM, Rector DM, Churchill L.  Cytokines and Sleep.  In:  Neuroimmune Biology; Vol 6: Cytokines and the Brain.  Phelps C, Kornova E (eds); Elsevier BV: Oxford.  (In press)

313. Churchill L, Taishi P, Wang M, Brandt J, Cearley C, Krueger JM.  (2006)  Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1 or tumor necrosis factor α.  Brain Res 1120: 64-73.

314. Traynor T, Majde JA, Bohnet S, Krueger JM.  (2007)  Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus.  Brain Behav Immunity 21: 311-322.

315. Krueger JM, Churchill L, Rector DM.  Sleep and sleep states: cytokines and neuromodulation.  The New Encyc Neurosci.  (In press)

316. Szentirmai , Kapas L, Krueger JM.  (2007)  Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats.  Am J Physiol 292: R575-R585.

317. Yasuda K, Churchill L, Yasuda T, Blindheim K, Falter M, Krueger JM.  (2007)  Unilateral cortical application of interleukin-1b (IL1b) induces asymmetry in Fos- and IL1b-immunoreactivity: Implications for sleep regulation.  Brain Res 1131: 44-59.

318. Cambras T, Weller JR, Angles-Pujoras M, Lee M, Christopher H, Oiez-Noguera A, Krueger JM, de la Iglesia H.  (2007) Desynchronization of core body temperature and sleep stages is associated with uncoupling of oscillators within the master circadian clock.  Proc Natl Acad Sci.  104: 7634-7639.

319. Krueger JM, Rector DM, Churchill L.  Sleep and cytokines.  (2007)  Sleep Med Clinics.  2: 161-169.

320. Majde JA, Bohnet SG, Ellis GA, Churchill L, Leyva-Grado V, Wu M, Szentirmai , Rehman A, Krueger JM.  (2007)  Detection of a mouse-adapted human influenza virus in the olfactory bulb of mice within hours after intranasal infection.  J NeuroVirol 13: 399-409.

321. Szentirmai , Kaps L, Sun Y, Smith RG, Krueger JM.  (2007)  Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice.  Am J Physiol 293: R510-R517.

322. Manoranjan VS, Rajapakse I, Krueger JM.  (2006)  Oscillation in a neuronal assembly A phenomenological model.  Int J Computa Appl Math Vol 1, No 1.

323. Taishi P, Churchill L, Wang M, Kay D, Davis CJ, Guan X, De A, Yasuda T, Liao F, Krueger JM.  (2007)  TNFa siRNA reduces brain TNF and EEG delta wave activity in rats.  Brain Res 1156: 125-132.

324. Davis CJ, Bohnet SG, Meyerson JM, Krueger JM.  (2007)  Sleep loss changes microRNA levels in the brain: A possible mechanism for state-dependent translational regulation.  Neurosci Lett 422: 68-73.

325. Szentirmai , Yasuda T, Taishi P, Wang W, Churchill L, Bohnet S, Magrath P, Kacsh B, Jimenez L, Krueger JM.  (2007)  Growth hormone releasing hormone: Cerebral cortical sleep-related EEG actions and expression.  Am J Physiol 293: R922-R930.

326. Krueger JM.  (2009) What exactly is it that sleeps?  The evolution, regulation and organization of an emergent network property.  In: The Evolution of Sleep: Phylogenetic and Functional Perspectives.  P McNamara, R Barton, C Nunn (eds); Cambridge University Press.  (In press)

327. Krueger JM, Leyva-Grado V, Bohnet S.  Cytokines, host defense and sleep.  Atlas Clin Sleep Med.  Elsevier: Philadelphia, PA.  (In press)

328. Von Dongen HPA, Rector DM, Belenky G, Krueger JM.  Sleep a localized phenomenon of the brain.  Atlas Clin Sleep Med.  Elsevier: Philadelphia, PA.  (In press)

329. Szentirmai E, Kapas L, Krueger JM. Interactive regulation of sleep and feeding. Atlas Clin Sleep Med. Chapter 3.9, Elsevier: Philadelphia, PA (In press).

330. Churchill L, Rector DM, Yasuda K, Fix C, Rojas MJ, Yasuda T, Hall SJ, Guan X, Krueger JM.  (2008) Tumor necrosis factor a: activity dependent expression and promotion of cortical column sleep in rats.  Neuroscience  156:71-80.

331. Roy S, Krueger JM, Rector DM, Wan Y.  (2008) Network models for activity-dependent sleep regulation.  J Theor Biol.  253:462-468.

332. Krueger JM.  (2008) The role of cytokines in sleep regulation.  Current Pharm Design 14:3408-3416. 

333. Bohnet S, Kaps L, Traynor T, Majde JA, Szentirmai , Magrath P, Taishi P, Krueger JM.  (2008) Spontaneous and influenza virus-induced sleep are altered in TNFα double receptor deficient mice.  J Appl Physiol 105: 1187-1198.

334. Taishi P, Churchill L, De A, Obal Jr F, Krueger JM.  (2008) Cytokine mRNA induction by interleukin-1 beta or tumor necrosis factor alpha in vitro and in vivo.  Brain Res. 1226:89-98.

335. Krueger JM, Rector DM, Roy S, VanDongen HPA, Belenky G, Panksepp J. (2008) Sleep as a fundamental property of neuronal assemblies. Nature Reviews Neuroscience 9: 910-919.

336. Krueger JM, Majde JA (2009) Immunity and sleep. In: Sleep Medicine Essentials. Ed: Teofilo L., Lee-Chiong. John Wiley & Sons, Inc. pp 223-226.

337. Krueger JM (2008) Humoral regulation of sleep; implications for sleep as an emergent use-dependent local process. Revista Medica de la Universidad Veracruzana Supp 2 vol 8: 46-52.

338. Peterfi Z, Makara GB, Obal Jr F. Krueger JM (2009) The anterolateral projections of the medial basal hypothalamus affect sleep. Am. J. Physiol., 296: R1228-$1238.

339. Rector DM, Schei JL, VanDongen HPA, Belenky G, Krueger JM. (2009) Physiological markers of localized sleep. Europ. J. Neurosci 29:1771-1778.

340. Krueger JM, Szentirmai E, Papas L. The biochemistry of sleep function. SRS Basics of Sleep Guide; Sleep Research Society (In press).

341. Leyva-Grado V, Churchill L, Wu M, Williams TJ, Taishi P, Majde JA, Krueger JM. Influenza virus and cytokine immunoreactive cells in the murine olfactory pathway and hypothalamus before and after illness onset. J. Neuroimmunol. (In press).

342. May U, Schiffelholz T, Baier PC, Krueger JM, Rose-John S, Scheller J. IL-6-trans-signalling increases rapid eye movement sleep in rats. European J. Pharmacology (In press).