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The techniques used
combine morphology, electrophysiology, tissue culture and molecular biology.
The trajectories of growing neurons are assessed using fluorescent and tissue
culture techniques in both the embryonic and neonatal nervous system. In
addition, a wide variety of histological techniques is used to define patterns
of innervation and synpatic development. Such studies can be used to estimate
the physiological development of synaptic connections in the nervous system.
The goal of these studies is to provide insight into mechanisms of nerve
regeneration and its potential for repair. Moreover, an understanding of
guidance mechanisms in embryonic development may provide better understanding
of birth defects involving the nervous system.
Biographical Information
Michael B. Laskowski,
Professor, received a B.S. in biology from Loyola University in Chicago in
1966 and a Ph.D. in Physiology from the University of Oklahoma School of
Medicine in 1970. He did postdoctoral research in neurophysiology at
Northwestern and Vanderbilt Universities and served on the faculties at both
Vanderbilt and St. Louis University schools of medicine. In 1988, he joined
the faculty at both Washington State University and the University of Idaho.
Selected Publications
Wang, H., Chadaram, S.R., Norton, A.S.,
Lewis, R., Boyum, J., Trumble, W., Sanes, J.R., & Laskowski, M.B.
(1999). Positionally selective growth of embryonic spinal cord
neurites on muscle membranes. J Neurosci 15: 4984-4993.
Feng, G., Laskowski, M.B., Feldheim,
D.A., Wang, H., Lewis, R., Frisen, J., Flanagan, J. & Sanes, J.R.
(2000). Roles for ephrins in positionally selective synaptogenesis
between motor neurons and muscle fibers. Neuron 25: 295-306.
Wang, H., Chadaram, S.R., Norton, A.S.
& Laskowski, M.B. (2001). Development of inhibition by ephrin-A5 on
outgrowth of embryonic spinal motor neurites. J Neurobiology
47: 233-243.
Chadaram,S.R. and M.B. Laskowski
(2003) Denervation and age modify neuromuscular positional
selectivity. J Neurobiology 56:347-359.
Lampa,S.J., Potluri,S., Norton,A.S.
and Laskowski, M.B. (2004). A morphological technique for exploring
neuromuscular topography expressed in the mouse gluteus maximus
muscle. J Neursci Meth 138: 51-56
Lampa, S., Potluri,S.,Norton, A.S.,
Fusco, W.F. and Laskowski, M.B. (2004) Ephrin A5 overexpression
degrades topographic specificity in the mouse gluteus maximus
muscle. Dev Brain Res 153: 271-274.
Potluri, S.,Lampa, S.J., Norton, A.S.
and Laskowski, M.B. (2006). Morphometric analysis of neuromuscular
topography in the serratus anterior muscle. Muscle and Nerve
33: 398-408.
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