Jonathan Wisor, Ph.D.
Assistant Professor
E-Mail: J_Wisor@wsu.edu
Office: 320K Health Science Bldg,
WWAMI Medical Education Program, WSU Spokane
Phone: (509) 358-7577
Humans spend roughly one-third of their lives
asleep. Sleep insufficiency has a number of negative effects on health
and well-being. The function that is served by sleep and the mechanisms
by which sleep insufficiency causes health problems are not well
understood. The purpose of my research program is to identify functional
consequences of sleep and sleep loss within the nervous system. My
laboratory has received funding from the Department of Defense (Defense
Advanced Research Projects Agency, Young Faculty Award) and the National
Institute of Neurological Disorders and Stroke to apply molecular
genetic and biochemical techniques in studies of the regulation of
sleep. These projects are aimed at characterizing the roles of genetic
loci and discrete cell populations within the cerebral cortex in
regulating sleep and sleep-related electroencephalographic wave forms.
We use gene expression and protein profiling in microglial and neuronal
cell populations to identify putative regulators of sleep. We use germ
line targeted optogenetic constructs to modulate the activity of
discrete cell types and measure the effects of these manipulations on
sleep. Working with research partners, we perform studies on human
subject populations to apply the findings of basic neurobiological
studies to issues related to human health.
The Wisor lab personnel: (L-R) Chelsea Stone
(undergraduate research assistant); Jonathan Wisor (principal
investigator); William Clegern (research technologist); Michelle Schmidt
(research technologist)
Biographical Information
Dr. Wisor received a Bachelor of Science degree in psychology from
Pennsylvania State University. He received a PhD in Neuroscience from
the University of California, Los Angeles. He then served as a
postdoctoral fellow and subsequently as a research associate at Stanford
University School of Medicine. From 2004 through 2008 he was a staff
scientist at SRI International, a non-profit research institute in Menlo
Park, California. He has served on the faculty of Washington State
University and the WWAMI (Washington, Wyoming, Alaska, Montana, Idaho)
Medical Education Program since December of 2008.
Selected Publications (click active titles for links)
Wisor JP,
Rempe MJ, Schmidt MA, Moore ME, Clegern WC (2012)
Sleep slow wave activity regulates cerebral glycolytic metabolism.
Cerebral Cortex,
in press PMID: 22767634.
Clegern WC, Schmidt MA,
Moore ME,
Wisor JP
(2012) Simultaneous electroencephalography, real-time measurement of
lactate concentration and optogenetic manipulation of neuronal activity
in the rodent cerebral cortex.
Journal of Visualized Experimentation,
in press.
Jiang P, Franklin KM,
Duncan MJ, O’Hara BF,
Wisor JP (2012)
Distinct phase relationships between suprachiasmatic molecular rhythms,
cerebral cortex molecular rhythms and behavioral rhythms in early runner
(CAST/EiJ) and nocturnal (C57BL/6J) mice.
Sleep,
in press.
Wisor JP,
Schmidt MA (2012)
Interleukin 1 receptor signaling mediates methamphetamine- and sleep
deprivation-induced hypersomnolence.
Neurosci Lett, 513(2):209-13 PMID: 22387068.
Wisor JP
(2012)
A metabolic-transcriptional network links sleep and cellular energetics
in the brain.
Pflugers Arch. Eur J Physiol, 463:15-22 PMID: 21927810.
Wisor JP,
Clegern WC and Schmidt MA (2011)
Toll-like receptor 4 is a regulator of monocyte and
electroencephalographic responses to sleep loss.
Sleep 34(10):1335-45 PMID:
21966065.
Wisor JP,
Clegern WC and Schmidt MA (2011)
Cerebral microglia mediate sleep/wake and neuroinflammatory effects of
methamphetamine.
Brain Behavior and Immunity,
25(4):767-76 PMID: 21333736.
Wisor JP
and Clegern WC (2011)
Quantification of short-term slow wave sleep homeostasis and its
disruption by minocycline in the laboratory mouse.
Neurosci Lett,
490(3):165-9 PMID: 21111032.
Krueger JM, Wisor JP (2011),
Local
use-dependent sleep, an introduction
Curr Topics Med Chem
11:2390-1 PMID: 22181666.
Wisor JP
et
al., (2011)
Sleep-active neuronal nitric oxide synthase-positive
cells of the cerebral cortex: a local regulator of sleep?
Curr Topics Med Chem
11(19):2483-9 PMID: 21906016.
Gerashchenko D, Wisor JP,
Kilduff TS (2011)
Sleep-active cells in the cerebral cortex and their role in slow-wave
activity,
Sleep Biol Rhythms
9(s1):71-77 PMID: 21625335.
Wisor JP
et al.,
(2011)
Evidence for neuroinflammatory and microglial changes in the cerebral
response to sleep loss,
Sleep 34(3):261-72 PMID: 21358843.
Jiang P, Striz M,
Wisor JP and O’Hara BF (2011)
Behavioral and genetic dissection of a mouse model for advanced sleep
phase syndrome, Sleep 34:39-48 PMID:
21203370.
Morairty SR, Wisor JP, Sinko
W, Silveira K, Kilduff TS (2011)
The
wake-promoting effects of hypocretin-1 is attenuated in old rats
Neurobiology of Aging,
32:1514-27 PMID: 19781813.
Oonk M, Davis CJ, Krueger JM,
Wisor JP, Van Dongen HPA (2011)
Investigating the Two-Trial
Y-Maze as a Performance Assay for Sleep Deprivation Studies in C57BL/6
mice.
Netherlands Sleep-Wake
Organization Yearbook 2011 22: 72-75.
Thompson CL, Wisor JP,
et al., (2010)
Molecular anatomic signatures of sleep deprivation in the mouse brain,
Front Neurosci. 4:165 PMID: 21088695.
