College of Veterinary Medicine

Veterinary Microbiology and Pathology

Program in Genomics




Directors

Kelly A. Brayton and Douglas R. Call

Goals

  • Encourage interdisciplinary collaborations and graduate and post-graduate research opportunities.
  • Examine genetic diversity as it relates to differential survivorship and virulence.
  • Identify mechanisms responsible for generating genetic diversity.
  • Develop new tools for diagnostics and strategies for pathogen control and intervention


Projects

Genome sequencing - Kelly A. Brayton
Anaplasma species
Babesia species 
Microarrays - Douglas R. Call
Detectors
ComparativeGenomics  
Expression Arrays
 

Program accomplishments

  • Whole genome comparative analysis of Anaplasma marginale strains
  • Genome sequences for attenuated and virulent strains of Babesia bovis
  • Genome sequences for Mannheimia haemolytica
  • Optical mapping of EHEC genotypes
  • Developed mixed-genome and mixed-plasmid microarrays to study molecular epidemiology of food-borne pathogens and antibiotic resistance traits.
  • Developing arrays suitable for simultaneous detection of multiple pathogens.


Publications related to this program

Faculty

Thomas E. Besser
Kelly A. Brayton
Douglas R. Call
Donald P. Knowles
Audrey O.T. Lau
Terry F. McElwain
Guy H. Palmer
Devendra Shah
Subramaniam Srikumaran
Example of genomic hybridizations for two strains of L. monocytogenes (serotypes 1/2a, top and 4b, bottom). Only a portion of the full array is shown. Spots clearly visible indicate presence of target. Missing spots are attributable to absent or highly diverged sequence (e.g., column 1, row 4).
 

This Program receives support from the following sources

National Institutes of Health (NIH) USDA-AFRI (formally NRIGCP)
USDA-ARS ADRU Microbial Genomics Initiative
USDA Northwest Aquaculture Initiative
WSU College of Veterinary Medicine Agricultural Animal Health Program
Last Edited: Mar 21, 2011 2:20 PM   

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