Program in Genomics
Directors
Kelly A. Brayton and Douglas R. Call
Goals
- Encourage interdisciplinary collaborations and graduate and
post-graduate research opportunities.
- Examine genetic
diversity as it relates to differential survivorship and virulence.
-
Identify mechanisms responsible for generating genetic diversity.
-
Develop new tools for diagnostics and strategies for pathogen
control and intervention
Projects
|
|
|
Microarrays - Douglas R.
Call |
Detectors
ComparativeGenomics
Expression Arrays |
 |
|
Program accomplishments
- Whole genome comparative analysis of
Anaplasma marginale strains
- Genome sequences for attenuated and virulent
strains of
Babesia bovis
- Genome sequences for Mannheimia
haemolytica
- Optical mapping of EHEC genotypes
- Developed mixed-genome and mixed-plasmid
microarrays to study molecular epidemiology
of food-borne pathogens and antibiotic
resistance traits.
- Developing arrays suitable for simultaneous
detection of multiple pathogens.
Faculty
Thomas E. Besser
Kelly A. Brayton
Douglas R. Call
Donald P. Knowles
Audrey O.T. Lau
Terry F. McElwain
Guy H. Palmer
Devendra Shah
Subramaniam Srikumaran |
Example
of genomic hybridizations for two strains of L. monocytogenes
(serotypes 1/2a, top and 4b, bottom). Only a portion of the full
array is shown. Spots clearly visible indicate presence of target.
Missing spots are attributable to absent or highly diverged sequence
(e.g., column 1, row 4). |
 |
This Program receives support from the following
sources
National Institutes of Health (NIH) USDA-AFRI (formally
NRIGCP)
USDA-ARS ADRU Microbial Genomics Initiative
USDA Northwest Aquaculture Initiative
WSU College of Veterinary Medicine Agricultural Animal Health
Program
