|CD7||Leu 9, 3A1, gp40, T cell leukemia antigen|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 1 glycoprotein
|40 / 40|
|CD7 is the earliest marker antigen expressed in the T lineage, being found on T cell precursors in fetal liver and thorax prior to thymic colonization and in thymus and bone marrow. CD7 is expressed on most human thymocytes, a major subset of peripheral blood T cells, mature T cells, NK cells, pluripotential hematopoietic stem cells, and progenitor cells of lymphoid and myeloid cells. CD7 is a marker for pluripotential stem cell leukemias and T cell acute lymphocytic leukemia.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.|
CD7 is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains a N-terminal Ig-like V-type domain followed by a putative O-glycosylated extended "stalk" which is separated from the transmembrane sequence by 4 consensus repeats containing a high proportion of Pro, Ser and Thr residues. The extended stalk is like that proposed for the CD8 hinge. The gene for CD7 is similar to the murine Thy-1 gene which places it in a class of tissue-specific genes whose promoters lack a TATA element.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
The extracellular region contains 2 potential N-linked glycosylation sites.
|No ligand for the extracellular region of CD7 has been identified. On crosslinking with mAb, CD7 associates with PI 3-kinase possibly through a YXXM motif in the cytoplasmic domain.|
LIGANDS AND MOLECULES ASSOCIATED WITH CD7
|Cross-linking studies with mAbs suggest that CD7 can function as a co-stimulatory molecule after T cell activation, induce cytokine secretion and modify cellular adhesion. CD7 plays an essential role in T cell interactions and also in T cell/B cell interaction during early lymphoid development indicating an important role in regulatory T cell and NK-T cell ontogeny and prevention of autoimmune disease. A proposal that CD7 is an IgM receptor has not been confirmed in expression studies using the mDNA clone. CD7 mAbs co-stimulate T cell proliferation and induce 2nd messengers. Soluble recombinant CD7 has been reported to inhibit antigen-specific T cell proliferation in a mixed lymphocyte reaction. A CD7 deficient mouse might give clues on the physiological function of CD7 in the development of T cells and other leukocyte lineages.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD7 IN INTACT ANIMAL
Studies have implicated CD7 as a co-activation molecule that modulates cytokine secretion and adhesion of cells treated mAb. A CD7 deficient patient with severe combined immunodeficiency (SCID) has been described. CD7 is a clinical marker for T cell acute lymphocyte leukemia. ALL), pluripotential stem cell leukemia, acute myleoid leukemia (ALL) and myelodysplasia. It is also a potential therapeutic target in the treatment of rheumatoid arthritis and may be a useful target for immunosuppression in transplant patients
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD7: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD7: No information.
Database accession numbers
Revised June 25, 2008