|CD75s||Alpha-2,6-sialylated lactosamines, CDw76|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|67 / 67|
85 / 85
|CD75s, formally was CDw76, is expressed on mature sIg+ B cells, the mantle zone B cells of lymphoid secondary follicles, the subpopulation of T cells CD8+ > CD4+, mature B lineage leukemias, subsets of endothelial and epithelial cells but B-ALL is negative. CD75s has a minor reaction with T cells and myeloid cells. Some CD75s mAbs react with erythrocytes. Expression is lost on germinal center and plasma cell differentiation.|
|MOLECULAR FAMILY NAME: Belongs to the carbohydrate group.|
CD75s comprises sialylated lactosamines. CD75s is a core peptide which is dependent on the presence of the β-galactose α2,6 sialyltransferase lactosamines. The carbohydrate epitopes are expressed on various glycosphingolipids and glycoproteins has been demonstrated.
The mass is not relevant because it is a carbohydrate epitope.
POST-TRANSCRIPTIONAL MODIFICATION: Not relevant.
POST-TRANSLATIONAL MODIFICATION: No information.
| LIGANDS AND MOLECULES ASSOCIATED WITH CD75s: No information.|
|CD75s epitopes have been considered as binding partners for the B cell specific activation antigen CD22. |
CD75s is an epitope dependent on a2 ,6 sialyltransferase activity.
DISEASE RELEVANCE AND FUNCTION OF CD75s IN INTACT ANIMAL
The glycotopes may be involved in the regulation of CD95 mediated apoptosis and be important for infection by a lymphotropic virus. CD75s differentiates between malignant B -cell types.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD75s: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD75s
a2 ,6 sialylated polylactosamine epitope are possibly expressed on glycosphingolipids and glycoproteins with a 85/67 kDa.
Database accession numbers
Revised June 25, 2008