CD75s Alpha-2,6-sialylated lactosamines, CDw76
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
B Cell
T Cell
Leukemia cell
Endothelial Cell
Epithelial Cell
Myeloid Cell
Erythrocyte
67 / 67
85 / 85

Expression
CD75s, formally was CDw76, is expressed on mature sIg+ B cells, the mantle zone B cells of lymphoid secondary follicles, the subpopulation of T cells CD8+ > CD4+, mature B lineage leukemias, subsets of endothelial and epithelial cells but B-ALL is negative.  CD75s has a minor reaction with T cells and myeloid cells.  Some CD75s mAbs react with erythrocytes.  Expression is lost on germinal center and plasma cell differentiation.



Structure
MOLECULAR FAMILY NAME: Belongs to the carbohydrate group.

CD75s comprises sialylated lactosamines.  CD75s is a core peptide which is dependent on the presence of the β-galactose α2,6 sialyltransferase lactosamines.  The carbohydrate epitopes are expressed on various glycosphingolipids  and glycoproteins has been demonstrated.
 
MOLECULAR MASS
Cell Type Unreduced Reduced
 67 kDa, 85 kDa

The mass is not relevant because it is a carbohydrate epitope.

POST-TRANSCRIPTIONAL MODIFICATION: Not relevant.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD75s: No information.



Function
CD75s epitopes have been considered as binding partners for the B cell specific activation antigen CD22. 

BIOCHEMICAL ACTIVITY

CD75s is an epitope dependent on a2 ,6 sialyltransferase activity.

DISEASE RELEVANCE AND FUNCTION OF CD75s IN INTACT ANIMAL

The glycotopes may be involved in the regulation of CD95 mediated apoptosis and be important for infection by a lymphotropic virus.  CD75s differentiates between malignant B -cell types.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD75s: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD75s
Molecule Comment
Neuraminidases with a2,6 activity Cleavage

ADDITIONAL INSIGHTS

 a2 ,6 sialylated polylactosamine epitope are possibly expressed on glycosphingolipids and glycoproteins with a 85/67 kDa.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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