|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
Interdigitating reticulum cell
|40 / 40|
45 / 45
|CD83 is expressed on non-follicular, circulating, and interdigitating dendritic cells within lymphoid tissues, Langerhans cells, in vitro generated thymic dendritic cells and polymorphononuclear cells. Expression reacts with some EBV-transformed lymphoblastoid cell lines, Hodgkin cells and with some germinal B cells in vivo. CD83 is used as a marker for a subset of mature dendritic cells. In the mouse, CD83 is expressed in the brain and spleen but it is not specific for dendritic cells in human. |
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.|
CD83 is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains an Ig-like V-type domain and is heavily glycosylated, a transmembrane and a 39 aa short C-terminal cytoplasmic domain. The gene for CD83 has an unusual structure, with respect to most other IgSF molecules, in that the intron/exon boundaries encompassing the IgSF domain are of phase 0 and phase 1 rather than both being of phase 1. There is also an intron within the coding sequence for the IgSF domain.
Alternative splicing yields 3 different isoforms, CD83a, b and c. Only one isoform, CD83c, has thus far been found to be a functional soluble isoform detectable in serum.
CD83 is heavily glycosylated.
| LIGANDS AND MOLECULES ASSOCIATED WITH CD83: No information.|
|CD83 is a dendritic cell marker. CD83 may play a role in antigen presentation and/or lymphocyte activation and regulates immune reponse and may be involved in activating immune effector cells. Knockout mice have arrested development of CD4+ single-positive cells.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD83 IN INTACT ANIMAL
CD83 levels are increased in serum of leukemia patients.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD83: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD83: No information.
CD83 is currently one of the best markers for human mature dendritic cells.
Database accession numbers
Revised June 25, 2008