CD92 SLC44A1 (solute carrier family 44, member 1), CHTL1, p70, CDw92
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 3 glycoprotein, 10 span
Myeloid Cell
Monocyte
Granulocyte
Mast Cell
Neutrophil
Peripheral blood
T Cell
70 / 70

Expression
CD92, formally was CDw92, is expressed on peripheral blood monocytes, neutrophils, granulocytes, T cell lines and myeloid cell lines.  There is a weak mAb reactivity with peripheral blood lymphocytes, fibroblasts, endothelial cells, and epithelial cells.  Expression is stronger on monocytes than on granulocytes.  It is expressed on mast cells but not on eosinophils or basophils.



Structure
MOLECULAR FAMILY NAME: Belongs to the choline transporter-like family.

CD92 is a multi-pass type-3, 10 span glycoprotein.  It contains an extracellular domain which contains 3 potential N-glycoslation sites, 10 transmembrane domains and a cytoplasmic C-terminal domain containing an ITIM motif.

MOLECULAR MASS
Cell Type Unreduced Reduced Comment
Various 70 kDa 70 kDa

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 3 different isoforms.

POST-TRANSLATIONAL MODIFICATION

CD92 is autophosphorylated.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD92

CD92 binds choline.


Function
CD92 is potentially a ligand transporter based on structural similarity to the choline transporter family.  CD92 transports choline for membrane phospholipid synthesis by immune cells but may also be involved in specific regulation of immune function via negative signaling pathways.  CD92 is associated with protein kinases which suggests involvement of this molecule in signal transduction.  However the signaling via the ITIM-like region has yet to be demonstrated.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD92 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD92: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD92: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene23446Q8WWI5
Antibodies
VIM15   View Reactivity

Revised June 25, 2008


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