|CD92||SLC44A1 (solute carrier family 44, member 1), CHTL1, p70, CDw92|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 3 glycoprotein, 10 span
|70 / 70|
|CD92, formally was CDw92, is expressed on peripheral blood monocytes, neutrophils, granulocytes, T cell lines and myeloid cell lines. There is a weak mAb reactivity with peripheral blood lymphocytes, fibroblasts, endothelial cells, and epithelial cells. Expression is stronger on monocytes than on granulocytes. It is expressed on mast cells but not on eosinophils or basophils.|
|MOLECULAR FAMILY NAME: Belongs to the choline transporter-like family.|
CD92 is a multi-pass type-3, 10 span glycoprotein. It contains an extracellular domain which contains 3 potential N-glycoslation sites, 10 transmembrane domains and a cytoplasmic C-terminal domain containing an ITIM motif.
Alternative splicing yields 3 different isoforms.
CD92 is autophosphorylated.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD92|
CD92 binds choline.
|CD92 is potentially a ligand transporter based on structural similarity to the choline transporter family. CD92 transports choline for membrane phospholipid synthesis by immune cells but may also be involved in specific regulation of immune function via negative signaling pathways. CD92 is associated with protein kinases which suggests involvement of this molecule in signal transduction. However the signaling via the ITIM-like region has yet to be demonstrated.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD92 IN INTACT ANIMAL: No information.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD92: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD92: No information.
Database accession numbers
Revised June 25, 2008