CD102 ICAM-2 (intercellular adhesion molecule-2)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Monocyte
Platelet
Dendritic Cell
Endothelial Cell
Lymphoma Cell
Lymphocyte
55 / 55
65 / 65

Expression
CD102 is expressed constitutively at high levels on vascular endothelial cells, on some resting lymphocytes, follicular dendritic cells on monocytes, on platelets but is not expressed on neutrophils.  Expression is more restricted than CD54 and, unlike CD54, there is little or no induction of CD102 on lymphocytes and endothelial cells by inflammatory mediators.  CD102 is induced in lymphomas.



Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.

CD102 is a single-chain type-1 254 aa glycotprotein.  It contained a 202 aa extracellular domain which contains 2 Ig-like C2-type domains, has 6 N-glycosyation sites and binds to the leukocyte adhesion LFA-1 protein, a 26 aa transmembrane domain and a 26 aa cytoplasmic domain. The 2 Ig domains share an ~36% sequence identity with the 2 membrane-distal IgSF domains of CD54 (ICAM-1) and CD50 (ICAM-3).   CD102 is a member of the intracellular adhesion molecule (ICAM) family.  
 
MOLECULAR MASS
Cell Type Unreduced Reduced Comment
HUVEC 55-65 kDa
B lymphoblastoid cell 55 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

There are 6 potential N-glycosylation sites in the extracellular domain.

Ligands
CD102 is a ligand for the leukocyte integrin CD11a/CD18 (LFA-1), like the related proteins CD54 and CD50.  CD102 has also been reported to bind CD11b/CD18 ( Mac-1).

LIGANDS AND MOLECULES ASSOCIATED WITH CD102
Molecule Comment
LFA-1 Ligand
CD11b/CD18 (Mac-1) This issue is still somewhat controversial



Function
CD102 is an intracellular adhesion molecule and is believed to be involved in lymphocyte recirculation and homing to inflammatory sites.  It also provides a costimulatory signal in the immune response through interaction with integrins.  CD102 is the major CD11a LFA-1 ligand on endothelial cells that have not been activated by inflammatory stimuli suggesting a possible role in lymphocyte recirculation by LFA-1 dependent cell adhesion.  It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation and other cellular interactions important for immune response and surveillance.  Recombinant CD102 can also stimulate T cells in vitro suggesting a role in T cell activation and adhesion.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD102 IN INTACT ANIMAL

CD102 knockout mice show impaired recruitment of inflammatory cells and reduced numbers of bone marrow megakaryocyte precursors.   CD102 is a potential pathology reagent because the CD102 levels are reportedly upregulated in lymph nodes with maignant infiltration.

Comments

MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD102: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD102: No information.



Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3384P13598
MouseA46510P35330X65493
Antibodies

Revised June 25, 2008


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