CD109 8A3, E123, Platelet activation factor
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
GPI anchor
Uterus
Platelet
Endothelium
Tumor Cell
Myeloid Leukemia
Heart
Lung
Placenta
Kidney
Spleen
T Cell
Aorta
Trachea
Megakaryoblastic Cell
Epithelial Cell
170 / 170

Expression
CD109 is expressed on activated T cells, platelets, human umbilical vein endothelial cells, acute myeloid leukemia cell lines and several tumor cell lines but it is not expressed on resting lymphocytes, neutrophils and erythrocytes.  Expression is on chronic myeloid leukemia.  There is a wide level of  expression in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver and spleen.
 


Structure
MOLECULAR FAMILY NAME: Belongs to the α2 microglobulin family of thioester-containing proteins.

CD109 is a GPI-anchored glycoprotein.  It contains a 21 aa N-terminal sequence and an extracellular domain which contains 17 potential N-linked carbohydrate glycosylation sites, a GPI-anchor site and a thioester motif characteristic of the α-2-macroglobulin.  About 50% of the antigen can be released from platelets by phosphatidylinositol-specific phospholipase C.  Multiple chains are observed by immunoprecipitation but the lower bands are proteolytic products of a single chain.  There are 2 N-linked sites that have been found by peptide mapping.  No change in polypeptide chain size is observed with O-glycanase.

MOLECULAR MASS
Cell Type Unreduced Reduced
175 kDa 175 kDa

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 4 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD109: No information.

Function
CD109 carries the epitopes for the Gov a/b alloantigen on platelets.  CD109 is a research reagent for the study of progenitor cell subsets.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD109 IN INTACT ANIMAL

Alloantibodies against CD109 have been identified in patients following multiple platelet transfusions. The alloantigenicity of CD109 has been implicated in post-transfusion purpura and alloimmune neonatal thrombocytopenia.


Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD109: No information.

SUBSTRATE: No information.

ENZYMES WHICH MODIFY CD109: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrez135228Q6YHK3
Antibodies

Revised June 25, 2008


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