CD113 

Nectin-3, PVRL3 (poliovirus receptor-related 3), CDw113

Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein		Epithelial Cell
Placenta
Kidney
Liver
Brain
Gut
Testis
61 / 61
100 / 100

Expression
CD113 is expressed on epithelial cells, testis, gut, kidney, brain, liver and placenta.  Nectin-3 is expressed at intracellular junctions



Structure

MOLECULAR FAMILY NAME: Belongs to the immunologlobulin  superfamily.

CD113 is a single-pass type-1 549 aa glycoprotein.  It contains an extracellular domain which contains 2 Ig-like C2-type domains, a N-terminal V-type domain and 6 potential N-glycosylation sites, a hydrophobic transmembrane domain and a cytoplasmic domain.  CD113 belongs to the nectin family with the Ig gene superfamily and has a 30% homology with CD111 and CD112.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 2 different isoforms.

POST-TRANSLATIONAL MODIFICATION: No information.



Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD113

The extracellular region of CD113 interacts with nectin-1 (CD111) and nectin-2 (CD112) and the poliovirus receptor CD155.  It can interact with nectin-3 on the same or on other cells (i.e. cis- and trans-homo-interaction.

Function

CD113, the other nectins, an adhesion molecule involved in the formation between adherens junctions beween epithelial cells.  The intracellular portion of CD113 binds to actin cytoskeleton through afadin.  The extracellular portion interacts with other nectin family members, CD155, CD111 and CD112.

BIOCHEMICAL ACTIVITY: No information.

DISEASE REVELANCE AND FUNCTION OF CD113 IN INTACT ANIMAL: No information.



Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD113: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD113: No information.

ADDITIONAL INSIGHTS

For further information see Raymond, N. et al (2000) Gene 255:347-355.




Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene25945Q9NQS3
Antibodies
Revised June 25, 2008


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