Nectin-3, PVRL3 (poliovirus receptor-related 3), CDw113
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|61 / 61|
100 / 100
|CD113 is expressed on epithelial cells, testis, gut, kidney, brain, liver and placenta. Nectin-3 is expressed at intracellular junctions|
MOLECULAR FAMILY NAME: Belongs to the immunologlobulin superfamily.
|LIGANDS AND MOLECULE ASSOCIATED WITH CD113|
The extracellular region of CD113 interacts with nectin-1 (CD111) and nectin-2 (CD112) and the poliovirus receptor CD155. It can interact with nectin-3 on the same or on other cells (i.e. cis- and trans-homo-interaction.
CD113, the other nectins, an adhesion molecule involved in the formation between adherens junctions beween epithelial cells. The intracellular portion of CD113 binds to actin cytoskeleton through afadin. The extracellular portion interacts with other nectin family members, CD155, CD111 and CD112.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD113: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD113: No information.
For further information see Raymond, N. et al (2000) Gene 255:347-355.
Database accession numbers
Revised June 25, 2008