|CD119||IFNGR1, IFNγR(interferon γR), IFNγRα|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|90 / 90|
100 / 100
| CD119 is expressed on monocytes, macrophages, T and B cells, NK cells, neutrophils, fibroblasts, epithelial cells, endothelium and a wide range of tumor cells. |
|MOLECULAR FAMILY NAME: Belongs to the cytokine type-2 receptor family.|
CD119 is a single-pass type-1 489 aa glycoprotein. It contains a 227 aa extracellular domain which contains 2 Ig-like C2-type domains, 2 fibronectin type-3 domains and has 5 potential N-linked glycosylation sites, a 22 aa transmembrane domains and a 222 aa intracellular cytoplasmic domain. The functional IFNg consists of a complex formed between CD119 and IFNg AF-1. Both CD119 and IFNg AF-1 belong to the class II cytokine receptor family within the Ig gene superfamily. The WSXWS motif, characteristic of class I cytokine receptors, is absent from both fibronectin type-3 domains in CD119 and IFNg AF-1.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD119|
IFNgR binds IFNg with a high affinity of kD = 1 nM-10 pM. Although CD119 alone can bind IFNg with a high affinity of kD = 50 pM and does not require the presence of IFNγAF-1 for ligand binding. The species-specific accessory factor IFNg AF-1, which interacts with the extracellular region of CD119, is required for signal transduction. In Colo-205 cells, a human adenocarcinoma cell line, the IFNgR receptor is constitutively phosphorylated on Ser and Thr residues and its phosphorylation is enhanced by IFNg or phorbol ester.
|CD119 forms part of the receptor to IFNγ. Despite being able to bind IFNγ on its own, CD119 must form a complex with IFNγAF-1 for signal transduction to occur. The CD119 receptorz plays a role in host defense and immunological processes and a role in the initiation and effector phases of immune responses, including macrophage activation, B and T cell differentiation, activation of NK cells and upregulating the expression of MHC Class I and II antigens in several cell types.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD119 IN INTACT ANIMAL
Defects in CD119 are a cause of familial disseminated atypical mycobacterial infection and disseminated BCG infection. CD119 deficient mice have greater susceptibility to Listeria monocytogenes and vaccine virus but are resistant to endotoxic shock.
|The IFNg AF-1 protein reconstitutes IFNg-induced Class I MHC expression, but not viral resistance, when transfected into heterologous cells together with the human CD119 and HLA-B7 genes. This suggests that other accessory factors are necessary for IFNg -mediated activities such as antiviral responses. Despite normal T cell responses, CD119-deficient mice show increased susceptibility to infection by Listeria monocytogenes and vaccinia virus, but are resistant to endotoxic shock.|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD119: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD119: No information.
Database accession numbers
Revised June 25, 2008