CD129 IL-9Rα chain
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
T Cell
B Cell
Leukemia cell
Erythroid Cell
Myeloid Cell
Eosinophil
Epithelial Cell
Macrophage
Neuron
Mast Cell
Hematopoietic Progenitor Cell
Megakaryoblastic Cell
64 / 64

Expression
CD129 is expressed on activated T cell lines, T and B cells, a megakaryoblastic leukemia cell line (Mo7E) and both erythroid and myeloid precursors.  Expression is on mast cells, eosinophils, hematopoietic progenitors, macrophages, epithelial cells and neurons.

Structure
MOLECULAR FAMILY NAME: Belongs to the hematopoietin family.

CD129 is a single-pass type-1 a chain 521 aa glycoprotein.  It contains an extracellular region which contains a N-terminal cytokine receptor domain contains the WSXWS motif (referred to as a fibronectin type-3 domain), a transmembrane domain and a 231 aa long cytoplasmic tail which contains a high percentage of Ser and Pro residues, including a stretch of 9 successive Ser residues, has a membrane proximal, proline-rich box 1 motif required for constritutive association with Janus kinase (JAK1), but lacks tyrosine kinase activity.  CD129 forms heterodimers with the common γ chain (CD132) which is shared by the receptors for IL-2, IL-4, IL7 IL-15 and IL-21.  Crosslinking analysis identified mouse CD129 as a 64 kDa glycoprotein, which is reduced to 54 kDa following N-glycosidase F treatment.  A soluble form of CD129 has been identified mice.

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD129

The IL-9R binds IL-9 with a kDa of ~100 pM as demonstrated for the receptors on a mouse T cell clone. The complex formed between CD129 and CD132 is essential for IL-9R-dependent signal transduction.

Function
CD129 is a receptor for IL-9R formed through the association of CD129 and CD132 (the common γ chain) forms the functional receptor IL-9, a growth factor for erythroid and myeloid progenitor cells.  IL-9 binding to CD129/CD132 complex results in phosphorylation of JAK1 bound to CD129 and JAK3 bound to CD132 and activation of the STAT, IRS-PI3 kinase and MAP kinase pathways.  CD129 signaling is important for intrathymic T cell development and promotes proliferation of Th clones and promotes the growth of activated T cells and Mo7E, and supports the generation of erythroid and myeloid precursors.  IL-9R also potentiates the IL-4R-induced production of IgG and IgE from B cells.  IL-9R stimulation of Mo7E cells induces Tyr phosphorylation of 4 unidentified proteins.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD129 IN INTACT AMINAL

Genetic studies suggest that there is an association between CD129 and development of asthma.  CD129 may play a role in tumorigenesis.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD129: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD129: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3581Q01113
MouseA45268Q01114M84746
Antibodies

Revised June 25, 2008


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