|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
Hematopoietic Progenitor Cell
|64 / 64|
|CD129 is expressed on activated T cell lines, T and B cells, a megakaryoblastic leukemia cell line (Mo7E) and both erythroid and myeloid precursors. Expression is on mast cells, eosinophils, hematopoietic progenitors, macrophages, epithelial cells and neurons.|
|MOLECULAR FAMILY NAME: Belongs to the hematopoietin family.|
CD129 is a single-pass type-1 a chain 521 aa glycoprotein. It contains an extracellular region which contains a N-terminal cytokine receptor domain contains the WSXWS motif (referred to as a fibronectin type-3 domain), a transmembrane domain and a 231 aa long cytoplasmic tail which contains a high percentage of Ser and Pro residues, including a stretch of 9 successive Ser residues, has a membrane proximal, proline-rich box 1 motif required for constritutive association with Janus kinase (JAK1), but lacks tyrosine kinase activity. CD129 forms heterodimers with the common γ chain (CD132) which is shared by the receptors for IL-2, IL-4, IL7 IL-15 and IL-21. Crosslinking analysis identified mouse CD129 as a 64 kDa glycoprotein, which is reduced to 54 kDa following N-glycosidase F treatment. A soluble form of CD129 has been identified mice.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD129|
The IL-9R binds IL-9 with a kDa of ~100 pM as demonstrated for the receptors on a mouse T cell clone. The complex formed between CD129 and CD132 is essential for IL-9R-dependent signal transduction.
|CD129 is a receptor for IL-9R formed through the association of CD129 and CD132 (the common γ chain) forms the functional receptor IL-9, a growth factor for erythroid and myeloid progenitor cells. IL-9 binding to CD129/CD132 complex results in phosphorylation of JAK1 bound to CD129 and JAK3 bound to CD132 and activation of the STAT, IRS-PI3 kinase and MAP kinase pathways. CD129 signaling is important for intrathymic T cell development and promotes proliferation of Th clones and promotes the growth of activated T cells and Mo7E, and supports the generation of erythroid and myeloid precursors. IL-9R also potentiates the IL-4R-induced production of IgG and IgE from B cells. IL-9R stimulation of Mo7E cells induces Tyr phosphorylation of 4 unidentified proteins.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD129 IN INTACT AMINAL
Genetic studies suggest that there is an association between CD129 and development of asthma. CD129 may play a role in tumorigenesis.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD129: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD129: No information.
Database accession numbers
Revised June 25, 2008