|CD136||MST1R (macrophage stimulating 1 receptor (c-met-related kinase)), RON, MSP-R, CDw136|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|150 / 150|
185 / 185
|CD136 (was CDw136) is expressed mainly on epithelial tissues including skin, kidney, lung, liver, intestine and colon and is expressed on certain established hematopoietic cells, neuroendrocine cells and keratinocytes. Expression is on monocytes, granulocytes and resident macrophages.|
|MOLECULAR FAMILY NAME: Belongs to the tyrosine kinase receptor family.|
CD136 is a single-chain type-1 1400 aa heterodimeric glycoprotein. It contains 3 IPT/TIG domains that have Ig-like folds and a Sema domain. There is an a chain and β chain are cleaved from a single gene product and are linked by a disulfide bond. The α chain is located extracellularly and the b chain consists of an extracellular domain, a transmembrane segment and an intracellular tyrosine kinase domain. CD136 is a member of the hepatocyte growth factor receptor subgroup of the receptor kinase family.
CD136 has 2 "chains" or "fragments" which result from the cleavage of a single gene product.
Alternative splicing yields 2 different isoforms. Splicing of the transcript results in a truncated protein with an in-frame deletion of 49 aa in the extracellular domain of the b chain.
CD136 contains a 185 kDa single chain precursor with glycosylation at the N-terminus. Proteolytic cleavage into the 2 chain form is linked by a disulfide bond. Ligand-dependent tyrosine phosphorylation of the kinase domain is in the b chain.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD136
|CD136 is the receptor for macrophage stimulating protein (MSP). Ligation-induced receptor dimerization induces cell migration, morphological change, cell growth, cytokine induction, and proliferation. The tyrosine kinase transmits apoptosis in different target cells as well as growth signals. CD136 is involved in the regulation of production of blood cells and in the development of epithelial tissue. It may also regulate ciliary beat frequency in epithelial cells.|
There is an increased kinase activity upon ligand-induced receptor dimerization.
DISEASE RELEVANCE AND FUNCTION OF CD136 IN INTACT ANIMAL
CD136 null mice fail to survive the peri-implantation period. CD136 +/- mice are highly susceptible to endotoxic shock.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD136: No information.
ENZYMES WHICH MODIFY CD136: No information.
Important areas of investigation are the physiological function of CD136 RON in vivo, the role in inflammation and wound healing and the mechanisms of activation in invasive growth and movement of epithelial tumors.
Database accession numbers
Revised June 25, 2008