|CD144||CDH5 (cadherin 5, type2 VE-cadherin vascular epithelium),|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|130 / 130|
135 / 135
|CD144 is expressed on stem cell subsets, endothelial cells, endothelia tissues and brain but is not expressed on any other cell types. |
|MOLECULAR FAMILY Belongs to the cadherin superfamily.|
CD144 is a type-1 784 aa glycoprotein. It contains an 593 aa extracellular region which contains 5 cadherin homologous repeats that form a rigid rod-like structure stabilized by the binding of Ca2+ ions between the repeats and contains 7 potential N-linked glycosylation sites, a transmembrane region and a highly conserved 164 aa cytoplasmic tail which has at the distal end a catenin-binding domain. It is a calcium-dependent cell-cell adhesion glycoprotein.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
CD144 has 7 potential N-glycosylation sites and 9 tyrosines in the cytoplasmic domain. The molecule can be phosphorylated on tyrosine.
|CD144 displays homotypic binding only.|
LIGANDS AND MOLECULES ASSOCIATED WITH CD144
|CD144 is a Ca++-dependent homophilic cell adhesion molecule found in adherens junctions in endothelial cells. Adherens junctions control endothelial cell-cell adhesion and migration of vascular endothelial cells as well as the permeability of microvascular endothelium. CD144 plays a role in the contact inhibition of endothelial cell growth. The functions of CD144 are modulated by various catenins, which are critical to its interaction with the cell cytoskeleton and its own intracellular trafficking. β-catenin and γ-catenin (plakoglobin) associate direcetly with catenin binding domain of the CD144 cytoplasmic domain and via α-catenin link the cadherin to the actin cytoskeleton. Plakoglobin can bind desmoplakin, which in turn mediates associates with the vimentin/intermediate filament cytoskeleton. p120-catenin associates with the juxtamembrane region of the cytoplasmic domain and plays a regulatory role in cadherin trafficking. Another catenin, p0071 (plakophilin-4) binds the same region of CD144 as p120-catenin and can bind desmoplakin and the ultimate link CD144 to the intermediate filament cytoskelton. CD144 functions by impairing to cells the ability to adhere in a homophilic manner and may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. |
CD144 has homotypic binding and VE-cadherin only binds to VE-cadherin.
DISEASE RELEVANCE AND FUNCTION OF CD144 IN INTACT ANIMAL
CD144 is involved in the loss of heterozgosity events in breast and prostate cancer. Expression is reduced in human angiosarcomas.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD144: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD144
Database accession numbers
Revised June 25, 2008