CD47R MEM-133, IAP, MER6, OA3, Rh-associated protein, gp42, neurophilin, CDw149
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Glycoprotein
Peripheral blood
Lymphocyte
Blood Cell
Monocyte
T Cell
B Cell
Erythroid Cell
115 / 115
125 / 125

Expression
CD47R, formally was CDw149, is expressed on peripheral blood lymphocytes, monocytes, is weak on neutrophils, eosinophils, platelets and is negative on erythrocytes.  Expression is on T cell lines HPB-ALL, Molt-4 and Jurkat, on B cell lines Raji, REH, CEB and Daudi and on the erythroid line K562 and early progenitor line KG1a. The level of expression on any subset of peripheral blood leukocytes does not markedly change after PHA in 3 days or PMA in 1 hour activation.


Structure
MOLECULAR FAMILY NAME: Belongs to the immunologlobulin gene superfamily.

CD47R is a glycoprotein.  CD47R mAbs have a low affinity for the CD47.  Also see CD47, a Rh-related antigen, integrin-associated signal transducer.

MOLECULAR MASS
Cell Type Unreduced Reduced
B-cell line Raji 120 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD47R: No information.

Function
CD47R may interact with integrins and have a role in intracellular calcium increase during cell adhesion.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD47R IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD47R: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD47R: No information.

ADDITIONAL INSIGHTS

Thus far, this is a poorly characterized molecule.  The only known characteristics are the cellular expression and the approximate Mr as determined by Western blotting of the nonreduced detergent lysate of the Raji cells. MEM-133 blocked the binding of FITC-labeled MEM-120 and vice versa to the cell surface indicating that both mAbs recognize a similar epitope.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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