CD153 CD30L, TNFSF8 (TNF superfamily, member 8)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 2 glycoprotein
Histiocyte
Myeloid Cell
Monocyte
Peripheral blood
Macrophage
Neutrophil
B Cell
Bone Marrow
Lymph Node
Eosinophil
Tonsil
Granulocyte
Erythroblast
Megakaryoblastic Cell
40 / 40

Expression
CD153 is mainly expressed on activated peripheral blood T cells and macrophages.  The messenger RNA for human CD153 is restricted to T cells and activated monocyte/macrophages and neutrophils in a particular way.  Expression is on eosonophils, normal and malignant B cells, normal bone marrow, myeloid cells, erythroblasts and a subset of megakaryoblasts.  Expression is on a small subset of lymphoid cells, histocytes and granulocytes in reactive lymph nodes and tonsils.  CD153 is widely expressed in hematopoietic malignancies.  Elevated expression by alveolar macrophages is present in sarcoidosis.

Structure
MOLECULAR FAMILY NAME: Belongs to the tumor necrosis factor superfamily.

CD153 is a single-chain type-2 234 aa glycoprotein.  It contains an 172 aa extracellular domain which contains 5 potential N-linked glycosylation sites and a C-terminal with similarity to TNF, a 25 aa transmembrane domain and a 37 aa cytoplasmic domain.  There is no apparent signal peptide.  CD153 has 2 cysteines which do not align with other members of the family which may form disulfide-linked multimers.  It thought that CD153 may form trimers.

MOLECULAR MASS
Cell type Unreduced Reduced Comment
40 kDa 40 Kda Unreduced 40 kDa plus dimers and with mouse CD153 higher oligomers

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULE ASSOCIATED WITH CD153

CD153 binds to CD30, a member of the TNFR superfamily.

Function
CD153 is a co-stimulatory signaling molecule for peripheral blood T cells.  It enhances antigen-induced proliferation and cytokine production by Th0 and Th2.  CD153 has the ability to upregulate the expression of CD30, release soluble CD30 and to produce IL-4 in pre-activated T cells upon culture.  The CD153-CD30 interaction co-stimulates T cell activation and proliferation, upregulates expression of adhesion molecules and stimulates cytokine release.  CD153 signaling enhances cytokine production by activated neutrophils.  A role for the CD153-CD30 interaction in deletion of thymocytes in the thymus is suggested from studies with CD30-deficient mice.  CD30+ T cell clones produce TH2-type cytokines.  A role for the CD153-CD30 interaction in the TH2-type autoimmune disease has been suggested.  T cell CD30 ligation of CD153 on IgD+IgM+ B cell specifically inhibits B cell Ig class switching and plasmacytoid.  CD30 ligation by CD153 induces Fas-independent cell death in T cell hybridoma.  CD153 signaling via CD30 has been demonstrated to play a role in the negative selection of autoreactive T cells within the thymus.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD153 IN INTACT ANIMAL

It was shown that CD153 enhanced cell proliferation, cytokine production and adhesion molecule expression in cell lines derived from Hodgkin's disease and some non-Hodgkin's lymphomas and CD30+ T-ALL but has cytostatic and cytotoxic effects on cell lines derived from large cell anaplastic lymphomas.  CD153 engagement with CD30 enhances HIV replication in CD4+ T cells from HIV positive individuals.


Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD153: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD153: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 944P32971
MouseB40710P32972L09754
Antibodies

Revised June 25, 2008


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