CD155 PVR (Poliovirus receptor),  NECL5 (nectin-like 5)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Monocyte
Macrophage
Thymocyte
Nervous system
Tumor Cell
Endothelial Cell
Epithelia
45 / 45

Expression
CD155 is expressed on monocytes, macrophages, some tumor cells and CD34+ thymocytes.  Expression is also on endothelial cells, epithelia and the central nervous system.

Structure
MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene superfamily.

CD155 is a single-pass type-1 417 aa glycoprotein.  It contains an extracellular domain which contains 2 Ig-like C2-type and 1 Ig-like V-type domains and 8 potential N-glycosylation sites, a transmembrane domain and a cytoplasmic domain.  The structure of CD155 is designated as a nectin-like molecule.

MOLECULAR MASS
Cell Type Unreduced Reduced
80 - 90 kDa

POST-TRANSCRIPTIONAL MODIFICATION

Alternative splicing yields 4 different isoforms, α, β, γ and δ.  Isoforms β and γ are secreted proteins and isoforms α and δ are membrane bound.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD155

CD155 binds with poliovirus and cytomegalovirus.  CD155 appears to bind vitronectin, CD56 and CD226 to CD111 (nectin-1) and CD112 (nectin-2) and is involved in homotypic adhesion.  CD155 and CD113 (nectin-3) binds integrin αVβ3.

Function
CD155 is an adhesion molecule involved in cell-cell and cell-extracellular matrix adhesion.  It makes a heterodimer with CD113 (nectin-3) and the complex binds integrin αVβ3. 

CD155 mediates NK cell adhesion and migration and triggers NK cell effector function binding two different NK cell receptors, CD96 and CD226.  These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell.  This may trigger adhesion and section of lytic granules and IFN-γ and stimulates cytotoxicity by activated NK cells.  CD155 may promote NK cell-target-cell modular exchange.  This transfer is more important in some tumor cells expressing a lot of the poliovirus, providing tumors with a mechanism of immunoevasion.  CD155, also has a possible interaction with CD44 in binding to hyaluronan.  It is proposed that the cytoplasmic domain may target CD155 containing endocytic vesicles to the microtubular network.  CD155 is though to regulate CD44 binding to hyaluronan and CD155 binds to the matrix protein vitronectin.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD155 IN INTACT ANIMAL

CD155 is a receptor for poliovirus infection and cytomegalovirus.

Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD155: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD155: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 5817P15151
Antibodies

Revised June 25, 2008


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