|CD156a||ADAM-8 (a disintegrin and metalloprotease domain 8), MS2 human, CD156|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|69 / 69|
89 / 89
|CD156a, which was CD156, is expressed on neutrophils, granulocytes, B cell lines, monocytes and upregulated by retinoic acid and vitamin D3. CD156a mRNA is expressed on macrophages and macrophage cell lines in mice. The level of expression of CD156a transcripts is upregulated following macrophage stimulation with LPS, phorbol ester or lymphokines. CD156a is expressed on myeloid cells and is also found in the central nervous system.|
|MOLECULAR FAMILY NAME: Belongs to the disintegrin and melloprotease family.|
CD156a is a single chain, type 1 824 aa glycoprotein. It contains a 16 aa signal peptide, a 637 aa extracellular domain which contains a cysteine-rich domain, a metalloproteinase domain, a distegrin domain and an epidermal growth factor-like (EGF) domain and 4 potential N-glycosylation sites, a 25 aa transmembrane domain and an 146 aa cytoplasmic domain which contains a proline-rich Src homology 3 (SH3) ligand domains and the region contains tandem repeats with homology to corresponding sequences in CD2 and CD122, (IL-2R b chain). Based on aa sequence similarity, the CD156a molecule is predicted to be a member of the zinc-dependent metalloprotease family.
Mature ADAM8 may lack Pro and MTP regions.
POST-TRANSLATIONAL MODIFICATION: No information.
| LIGANDS AND MOLECULES ASSOCIATED WITH CD156a: No information.|
|Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows a significant aa sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. CD156a is potentially involved in inflammation, cell adhesion, signal transduction and a possible involvement in the extravasation of leukocytes.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD156a IN INTACT ANIMAL
CD156a has been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertization, development and differentiation in muscle and neurogenesis. A mutant mouse with neurological defects (Wobbler mice) over-expresses CD156a in areas showing neurodegeneration and may be involved in cell adhesion. TNFα induced upregulation of CD156a 15-fold. These findings suggest that CD156a may have a role in degenerative disease.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD156a: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD156a: No information.
The mouse ADAM8 gene is comprised of 24 exons, 23 introns and spans 14 kb.
Database accession numbers
Revised June 25, 2008