CD156a ADAM-8 (a disintegrin and metalloprotease domain 8), MS2 human, CD156
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Monocyte
Macrophage
Neutrophil
Granulocyte
Myeloid Cell
B Cell
Nervous system
Lymphokine
69 / 69
89 / 89

Expression
CD156a, which was CD156, is expressed on neutrophils, granulocytes, B cell lines, monocytes and upregulated by retinoic acid and vitamin D3.  CD156a mRNA is expressed on macrophages and macrophage cell lines in mice.  The level of expression of CD156a transcripts is upregulated following macrophage stimulation with LPS, phorbol ester or lymphokines.  CD156a is expressed on myeloid cells and is also found in the central nervous system.


Structure
MOLECULAR FAMILY NAME: Belongs to the disintegrin and melloprotease family.

CD156a is a single chain, type 1 824 aa glycoprotein.  It contains a 16 aa signal peptide, a 637 aa extracellular domain which contains a cysteine-rich domain, a metalloproteinase domain, a distegrin domain and an epidermal growth factor-like (EGF) domain and 4 potential N-glycosylation sites, a 25 aa transmembrane domain and an 146 aa cytoplasmic domain which contains a proline-rich Src homology 3 (SH3) ligand domains and the region contains tandem repeats with homology to corresponding sequences in CD2 and CD122, (IL-2R b chain).  Based on aa sequence similarity, the CD156a molecule is predicted to be a member of the zinc-dependent metalloprotease family.

MOLECULAR MASS
Cell Type Unreduced Reduced
Neutrophil 69 kDa
Monocyte 69 kDa
MS2 75 kDa 89 kDa








POST-TRANSCRIPTIONAL MODIFICATION

Mature ADAM8 may lack Pro and MTP regions.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD156a: No information.



Function
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains.  The extracellular region of ADAM8 shows a significant aa sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains.  CD156a is potentially involved in inflammation, cell adhesion, signal transduction and a possible involvement in the extravasation of leukocytes.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD156a IN INTACT ANIMAL

CD156a has been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertization, development and differentiation in muscle and neurogenesis.  A mutant mouse with neurological defects (Wobbler mice) over-expresses CD156a in areas showing neurodegeneration and may be involved in cell adhesion.  TNF╬▒ induced upregulation of CD156a 15-fold.  These findings suggest that CD156a may have a role in degenerative disease.


 


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD156a: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD156a: No information.

The mouse ADAM8 gene is comprised of 24 exons, 23 introns and spans 14 kb.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 101P78325
MouseA60385Q05910X13335
Antibodies

Revised June 25, 2008


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