|CD160||BY55, NK1, NK28|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
|27 / 27|
80 / 80
|CD160 is expressed at the cell surface as a disulfide-linked multimer. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. RNA blot analysis has revealed the presence of CD160 mRNAs of 1.5 kb and 1.6 kb in subsets of circulating NK and T cells and cells in the spleen and small intestine. CD160 is expressed by CD56 dim CD16+ NK cells. In blood, expression is mainly restricted to gd T cells and ab + CD8 bright CD95+CD56+CD28-CD27- T cells. CD160 is expressed on all intestinal intraepithelial lymphocytes. Receptor expression of CD160 is downregulated following T and NK cell activation. CD160 is expressed on CTLs and IELs. |
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin gene superfamily.|
CD160 is a type-2 cysteine-rich GPI-anchored 181 aa glycoprotein It contains an 181 aa extracellular domain which contains a Ig-like V-type domain which has 6 cysteines in the mature polypeptide and 2 N-linked glycosylation sites. The Ig-like domain is weakly homologous to MHC binding receptors referred to as killer inhibitary receptors (KIR) and to the CD158d (KIR2DLA4) molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer.
CD160 is a 27 kDa glycoprotein which was initially identified with the mAb BY55.
POST-TRANSCRIPTIONAL MODICIATION: No information.
CD160 has 2 N-linked glycosylations.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD160|
CD 160 binds HLA-C molecules and displays broad specificity binding to classical and nonclassical MHC class I molecules.
|Cross-linking CD160 with certain mAbs or MHC class I provides a costimulatory signal to CD3-activated CD8+ T lymphocytes, enhancing their proliferation. After its engagement of an HLA-C molecule on a target cell, CD160 triggers cell cytotoxicity and the release of IFN-γ, TNF-α and IL-6 by NK cells. Cell surface expression of CD160 is downregulated by cytokine-induced NK cell activation.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD160 IN INTACT ANIMAL
CD160 expression is altered in patients with paroxysmal nocturnal hemoglobinuria.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD160: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD160: No information.
Database accession numbers
Revised June 25, 2008