CD165 AD2, gp 37, SN2
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Glycoprotein
Lymphocyte
Nervous system
Thymocyte
Keratinocyte
Platelet
T Cell
Leukemia cell
Neuron
Kidney
Epithelium
Pancreas
37 / 37
42 / 42

Expression
CD165 is expressed at high levels on a subset of peripheral lymphocytes, immature thymocytes, the majority of platelets, thymic epithelium cells, fibroblasts, epidermal keratinocytes, neurons and islet cells of the pancreas.  CD165 is highly expressed on many T cell type acute lymphoblastic leukemia  (T-ALL) cells, in the following tissues in the central nervous system (CNS) and Bowman's capsule of the kidney.  CD165 is expressed at lower levels on a proportion of circulating T cells and monocytes.
 


Structure
MOLECULAR FAMILY NAME

CD165 is a transmembrane glycoprotein is presently poorly characterized.

MOLECULAR MASS
Cell Type Unreduced Reduced
Unspecified 37 kDa 42 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD165: No information.


Function
CD165 has an active role in platelet formation in addition to involvement in leukocyte and endothelial cell adhesion.  CD165 is also involved in adhesion between thymocytes and thymic epithelial cell interaction.

BIOCHEMICAL ACTIVITY: Unknown.

DISEASE RELEVANCE AND FUNCTION OF CD165 IN INTACT ANIMAL

CD165 may be a useful marker of T-type acute lymphoblastic leukemia and as a marker for tumor progression.  CD165 is highly expressed on many T cell acute lymphoblastic leukemias (ALL).  MAbs to CD165 has a potential as a diagnostic marker for ALL.  In addition, studies in mice using toxin-conjugated anti-CD165 mAbs suggest that they may be of therapeutic value in ALL.

Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD165: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD165: No information.

OTHER COMMENTS:

As of 10/4/07 the Entrez gene 23449 for CD165 references Entrez gene 441457 and a family name of FAM22G (family with sequence similarity 22, member G) and a SwissProt Q5VZR2.  No further information


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene23449
Antibodies
AD2-13H12   View Reactivity
SN2   View Reactivity

Revised June 25, 2008


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