CD11d ITGAD (integrin αD subunit)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Leukocyte
Macrophage
Peripheral blood
Myelomonocytic cell
150 / 150

Expression
CD11d is expressed at moderate levels on peripheral blood leukocytes and myelomonocytic cell lines.  It is expressed strongly on specialized cells in tissues, for example splenic red pulp macrophages and foamy macrophages in aortic fatty streaks. 

Structure
MOLECULAR FAMILY NAME:  Belongs to the integrin α chain family.

CD11d is a single-pass type-1 an a chain glycopeptide.  It contains an extracellular domain which contains 7 tandem repeats and an integrin I domain (VWFA) near the N-terminus which is determined by protein sequencing, a transmembrane domain and a cytoplasmic domain.  The α integrin subunit combines with CD18, an integrin b2 subunit, to form the integrin aDb2. 

MOLECULAR MASS
Cell Type Unreduced Reduced
150 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD11d

The integrin aDb2 binds CD50 (ICAM-3), but not CD54 (ICAM-1) or CD106 (VCAM-1).

Function
CD11d is a receptor for CD50 and CD106.  It may play a role in the atherosclerotic process such as clearing liloproteins from plagues and in phagocytosis of blood-borne pathogens, particular matter and senescent erythrocytes from the blood.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD11d IN INTACT ANIMAL: No information.


Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD11d: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD11d: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 3681Q13349
Antibodies
CA11.8H2   View Reactivity
CA16.3D3   View Reactivity

Revised June 25, 2008


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