CD60c 7-O-acetyl-GD3 (7-O-aceylated disialosyl groups)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
T Cell
90 / 90

Expression
CD60c which was CDw60 is now divided into CD60a, CD60b, and CD60c.  CD60c is expressed on T cells.

Structure
MOLECULAR FAMILY NAME: Belongs to the carbohydrate family.

CD60c specific mAb U5 recognizes 7-O-aceylated disialosyl groups (7-O-acetyl GDS) linked either to lactosylceramide or to its analogues with 1 or 2 lactosamine disaccharide units in their carbohydrate chains.

MOLECULAR MASS
Cell Type Unreduced Reduced

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD60c: No information.


Function
The CD60c mAb U5 has a stronger T cell activating capacity than the CD60a mAb R24 and does not require co-stimulatory signals.  Since mAb R24 shows cross reactivity with 7-O-acetyl GD3, it is presumed that CD60c rather than CD60a is the activation receptor on T lymphocytes.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD60c IN INTACT ANIMAL

CD60c is a strong marker for malignant melanomas.  There is a high frequency of CD60+ T cells in synovial fluid of normal and arthritic patients and in cutaneous psoriatic lesions.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD60c: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD60c: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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