|CD60c||7-O-acetyl-GD3 (7-O-aceylated disialosyl groups)|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|T Cell||90 / 90|
|CD60c which was CDw60 is now divided into CD60a, CD60b, and CD60c. CD60c is expressed on T cells.|
|MOLECULAR FAMILY NAME: Belongs to the carbohydrate family.|
CD60c specific mAb U5 recognizes 7-O-aceylated disialosyl groups (7-O-acetyl GDS) linked either to lactosylceramide or to its analogues with 1 or 2 lactosamine disaccharide units in their carbohydrate chains.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
| LIGANDS AND MOLECULES ASSOCIATED WITH CD60c: No information.|
|The CD60c mAb U5 has a stronger T cell activating capacity than the CD60a mAb R24 and does not require co-stimulatory signals. Since mAb R24 shows cross reactivity with 7-O-acetyl GD3, it is presumed that CD60c rather than CD60a is the activation receptor on T lymphocytes.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD60c IN INTACT ANIMAL
CD60c is a strong marker for malignant melanomas. There is a high frequency of CD60+ T cells in synovial fluid of normal and arthritic patients and in cutaneous psoriatic lesions.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD60c: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD60c: No information.
Database accession numbers
Revised June 25, 2008