| B-G | Chicken molecules |
| Molecule Type | Antigen Expression | Molecular Weight Min / Max |
| Non-lineage Restricted Molecule Type 1 glycoprotein | B Lymphocyte Blood Cell B Cell, Bursal Nonhematopoietic Cell Thrombocyte T Lymphocyte Thymocyte | 30 / 165 |
Expression | ||||||||||||||
| Chicken B-G molecules are expressed on red blood cells, thrombocytes, B and T lymphocytes, bursal B cells, thymocytes and various non-hematopoietic cells. | ||||||||||||||
Structure | ||||||||||||||
| B-G is a homodimeric disulfide-linked type 1 glycoprotein. The multigene family of chicken B-G molecules is encoded within the chicken MHC. Structural information is given for erythrocyte B-G which is expressed mainly as a disulfide-linked dimer and contains no oligosaccharide. On other cells B-G molecules may be monomeric or multimeric and be glycosylated. The extracellular domain consists of 1 IgSF V-set domain which shows polymorphism and similarity to myelin oligodendrodyte glycoprotein (MOG). A superfamily of the IgSF containing BT, MOG, B-G, CD80 and CD86 has been suggested. The cytoplasmic domains is comprised of different numbers of 7 aa a helical repeats giving rise to size polymorphism. B-G has been identified as a polymorphic family in another species of birds, namely the pheasant. MOLECULAR MASS
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Revised June 25, 2008
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