B-G Chicken molecules
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
B Lymphocyte
Blood Cell
B Cell, Bursal
Nonhematopoietic Cell
Thrombocyte
T Lymphocyte
Thymocyte
30 / 165

Expression
Chicken B-G molecules are expressed on red blood cells, thrombocytes, B and T lymphocytes, bursal B cells, thymocytes and various non-hematopoietic cells.

Structure
B-G is a homodimeric disulfide-linked type 1 glycoprotein.  The multigene family of chicken B-G molecules is encoded within the chicken MHC.  Structural information is given for erythrocyte B-G which is expressed mainly as a disulfide-linked dimer and contains no oligosaccharide.  On other cells B-G molecules may be monomeric or multimeric and be glycosylated.  The extracellular domain consists of 1 IgSF V-set domain which shows polymorphism and similarity to myelin oligodendrodyte glycoprotein (MOG).  A superfamily of the IgSF containing BT, MOG, B-G, CD80 and CD86 has been suggested.  The cytoplasmic domains is comprised of different numbers of 7 aa a helical repeats giving rise to size polymorphism.  B-G has been identified as a polymorphic family in another species of birds, namely the pheasant.

MOLECULAR MASS
Cell Type Unreduced Reduced
90 - 160 kDa 35 - 55 kDa



Ligands


Function

 



Comments


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
ChickenM61860
Antibodies

Revised June 25, 2008


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