CD15u Sulphated CD15, 3' sulfated Lewis X
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
Lymph Node
Granulocyte
Monocyte
Lymphocyte
Neutrophil
NK Cell
Endothelial Cell
Bone Marrow
Endothelium
T Lymphocyte
Leukemia cell
Myelomonocytic cell

Expression
CD15u is expressed widely on neutrophils, basophils, mature granulocytes, monocytes, NK cells and T lymphocytes but expression on lymphocytes is variable depending on the antibodies used for detection.  Expression is present on immature bone marrow cells and on endothelial cells of high endothelium (HEV) of peripheral lymph nodes.  CD15u is expressed on myelomonocytic leukemia cells and on adenocarinomas.

Structure
MOLECULAR FAMILY NAME: Belongs to the carbohydrate family.

MOLECULAR MASS: No information.

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.


Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH CD15u: No information.



Function
CD15u form is the strongest binding partner for  CD62P (P-selectin).  CD15u is involved with different carbohydrate to carbohydrate cell adhesion.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD15u IN INTACT ANIMAL: No information.


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD15u: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD15u: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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