gp42 
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
GPI anchor
NK Cell
35 / 50

Expression
gp42 is not expressed on freshly isolated rat NK or T cells but its expression is selectively induced on NK cells in the presence of high concentrations of IL-2 in vitro.

Structure
gp42 is a single chain GPI-anchored glycoprotein.  It is comprised of 2 IgSF C2 domains.  The N-terminus and the site of addition of the GPI-anchor have not been determined.

MOLECULAR MASS
Cell Type Unreduced Reduced
40 - 45 kDa 40 - 45 kDa



Ligands


Function
The function of gp42 is unknown. However, like other GPI-anchored molecules, gp42 may be capable of transmitting intracellular signals since anti-gp42 mAbs cross-linked with secondary antibodies induce increases in intracellular Ca2+ and inositol phosphates in a rat leukemic cell line. gp42 mAbs do not block the natural killer activity of NK cells.

Comments


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
RatJH0372P23505X56448
Antibodies

Revised June 25, 2008


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