CD17 Lactosylceramide (LacCer)
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Glycosphingolipid
Neutrophil
Monocyte
Platelet
Basophil
B Lymphocyte
Dendritic Cell
Granulocyte
T Lymphocyte
115 / 115
165 / 165

Expression
CD17, formally CDw17, is expressed on neutrophils (both on the surface aqnd as cytoplasmic granules), monocytes, basophils, platelets, a CD19+ subset of 40% - 80% peripheral B cells and CD45+ tonsillar dendritic cells.  It is rapidly and extensively downregulated on activated granulocytes but is upregulated on IL-2 activated T lymphocytes.



Structure
MOLECULAR FAMILY NAME: Belongs to the lactosylceramide family.

CD17 is comprised of a lactosyl disaccharide group of the glycosphingolipid lactosyl ceramide (LacCer or Galb-4Glcb1-1Cer.  The antigen is not known to be associated with glycoproteins.

MOLECULAR MASS
Cell Type Unreduced Reduced
Diverse 165 kDa 115 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION: No information.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD17

The GM3 ganglioside on tumor cell lines has been shown to bind to CD17-coated surfaces.



Function
Function is unknown but CD17 mediates homotypic adhesion and  binds to bacteria and may function in phagocytosis.  CD17 is the most abundant glycosphingolipid present on neutrophils.  The majority of CD17 on neutrophils is contained in intracellular granules, where it has been proposed to participate in the exocytosis or packaging of granule contents.  Surface expression is markedly decreased after activation with a number of stimuli.  Downregulation is associated with membrane internalization and granule exocytosis, but not with superoxide production.  Treatment of neutrophils with CD17 mAbs induces a moderate release of calcium ions into the cytoplasm and stimulates a strong oxidative burst, but has little effect on CD11b and CD67 surface expression.  However, upregulation of CD17 expression is associated with the activation of platelets.  CD17 may be involved in intracellular trafficking.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD17 IN INTACT ANIMAL: No information.

Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD17: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD17: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies
Go35   View Reactivity

Revised June 25, 2008


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