|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
|115 / 115|
165 / 165
|CD17, formally CDw17, is expressed on neutrophils (both on the surface aqnd as cytoplasmic granules), monocytes, basophils, platelets, a CD19+ subset of 40% - 80% peripheral B cells and CD45+ tonsillar dendritic cells. It is rapidly and extensively downregulated on activated granulocytes but is upregulated on IL-2 activated T lymphocytes.|
|MOLECULAR FAMILY NAME: Belongs to the lactosylceramide family.|
CD17 is comprised of a lactosyl disaccharide group of the glycosphingolipid lactosyl ceramide (LacCer or Galb-4Glcb1-1Cer. The antigen is not known to be associated with glycoproteins.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD17|
The GM3 ganglioside on tumor cell lines has been shown to bind to CD17-coated surfaces.
|Function is unknown but CD17 mediates homotypic adhesion and binds to bacteria and may function in phagocytosis. CD17 is the most abundant glycosphingolipid present on neutrophils. The majority of CD17 on neutrophils is contained in intracellular granules, where it has been proposed to participate in the exocytosis or packaging of granule contents. Surface expression is markedly decreased after activation with a number of stimuli. Downregulation is associated with membrane internalization and granule exocytosis, but not with superoxide production. Treatment of neutrophils with CD17 mAbs induces a moderate release of calcium ions into the cytoplasm and stimulates a strong oxidative burst, but has little effect on CD11b and CD67 surface expression. However, upregulation of CD17 expression is associated with the activation of platelets. CD17 may be involved in intracellular trafficking.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD17 IN INTACT ANIMAL: No information.
|MOLECULAR INTERACTIONS -|
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD17: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD17: No information.
Database accession numbers
Revised June 25, 2008