CD217 IL17R (interleukin 17 receptor A), CDw217
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Type 1 glycoprotein
Hematopoietic Cell
Nonhematopoietic Cell
Thymocyte
Peripheral blood
B Cell
NK Cell
T Cell
Epithelial Cell
Fibroblast
Monocyte
Granulocyte
Macrophage
Lymphocyte
125 / 125
158 / 158

Expression
CD217, previously CDw217), mRNA is expressed on a wide range of hematopoietic and non-hematopoietic tissues and cell lines as well as cord blood lymphocytes, peripheral blood lymphocytes and thymocytes.  Expression is also on B, T and NK cells, fibroblasts, epithelial cells, monocytes, macrophages and granulocytes.

Structure
MOLECULAR FAMILY NAME: Belongs to the chemokine/cytokine receptor family.

CD217 is a single-pass type-1 866 aa glycoprotein.  It is contains a 293 aa extracellular domain which contains 6 potential N-linked glycosylation sites, a 21aa carboxy-proximal transmembrane domain and a large 525 aa cytoplasmic domain which contains 2 acidic regions and a Ser-rich region .  These domains are similar to those found in the CD122 (IL-2Rb) chain., the CD124 (IL-4Ra) chain and the CD114 (G-CSFR).  The CD217 does not contain sequence motifs linking it to previously identified cytokine receptor families.  Like other cytokine receptors, CD217 likely has a multimeric structure.

MOLECULAR MASS
Cell Type Unreduced Reduced
120 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION

CD217 is glycosylated.

Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD217

CD217 binds IL-17 is with low affinity.

Function
CD217 binds IL-17 with low affinity but IL-17 can stimulate cells at low concentration, suggesting that there is another component to the receptor which converts the interaction of high affinity.  IL-17 is a proinflammatory cytokine with a variety of effects including stimulation of IL-6 production.  CD 217 is associated with inflammatory disease and is a cytokine secreted by activated T lymphocytes.  It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils.  

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD217 IN INTACT ANIMAL

CD217 IL-17 is a proinflammatory cytokine with a variety of effects including stimulation of IL-6 production.  CD217 and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.  Control appears to be at the level of the cytokine rather than at the receptor, because the receptor is expressed widely and equally in health and disease.  






Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD217: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD217: No information.

Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene23765Q96F46
MouseU31993
Antibodies

Revised June 25, 2008


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