|CD217||IL17R (interleukin 17 receptor A), CDw217|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Non-lineage Restricted Molecule|
Type 1 glycoprotein
|125 / 125|
158 / 158
|CD217, previously CDw217), mRNA is expressed on a wide range of hematopoietic and non-hematopoietic tissues and cell lines as well as cord blood lymphocytes, peripheral blood lymphocytes and thymocytes. Expression is also on B, T and NK cells, fibroblasts, epithelial cells, monocytes, macrophages and granulocytes.|
|MOLECULAR FAMILY NAME: Belongs to the chemokine/cytokine receptor family.|
CD217 is a single-pass type-1 866 aa glycoprotein. It is contains a 293 aa extracellular domain which contains 6 potential N-linked glycosylation sites, a 21aa carboxy-proximal transmembrane domain and a large 525 aa cytoplasmic domain which contains 2 acidic regions and a Ser-rich region . These domains are similar to those found in the CD122 (IL-2Rb) chain., the CD124 (IL-4Ra) chain and the CD114 (G-CSFR). The CD217 does not contain sequence motifs linking it to previously identified cytokine receptor families. Like other cytokine receptors, CD217 likely has a multimeric structure.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
CD217 is glycosylated.
|LIGANDS AND MOLECULES ASSOCIATED WITH CD217|
CD217 binds IL-17 is with low affinity.
|CD217 binds IL-17 with low affinity but IL-17 can stimulate cells at low concentration, suggesting that there is another component to the receptor which converts the interaction of high affinity. IL-17 is a proinflammatory cytokine with a variety of effects including stimulation of IL-6 production. CD 217 is associated with inflammatory disease and is a cytokine secreted by activated T lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. |
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD217 IN INTACT ANIMAL
CD217 IL-17 is a proinflammatory cytokine with a variety of effects including stimulation of IL-6 production. CD217 and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Control appears to be at the level of the cytokine rather than at the receptor, because the receptor is expressed widely and equally in health and disease.
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD217: No information.
SUBSTRATES: No information.
ENZYMES WHICH MODIFY CD217: No information.
Database accession numbers
Revised June 25, 2008