CD173 Blood group H type-2, blood group O
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Non-lineage Restricted Molecule
Carbohydrate
Erythrocyte
Basal Cell
Red Cell
Endothelium
Carcinoma Cell
Myeloid Cell
Epithelium
Stem Cell
Leukemia cell
170 / 170

Expression
CD173 is expressed mainly on red cells, basal cells vascular and bronchial endothelium and erythrocytes.  It is expressed in a wide variety of carcinomas and poorly differentiated type-2 cells of normal human mammary epithelium and erythrocytes.  It is found that CD34+ leukemia cell lines, CD34+ myeloid precursor cell lines and naive CD34+ hematopoietic stem cells express CD173.  In contrast, CD34- cell lines and mature lymphocytes lack CD173.

Structure
MOLECULAR FAMILY NAME: Belongs to the Lewis blood group family.

CD173 is the monofucosylated form of the precursor carbohydrate chain belongs to the blood group H type-2 antigens and α1-2 Galβ1-4GlcNA is expressed on glycosphingolipids and glycoproteins on red cells.  In carcinoma cells, epithelial mucins are the major carrier molecules.  The expression is regulated by GDP-L-Fucose: b-D-Galactoside 2-a-L-Fucosyltransferase gene (FUT1).  The carrier molecule of CD173 in CD34+ hematpoietic stem cells is a 170 kDa glycoprotein. 

MOLECULAR MASS

POST-TRANSCRIPTIONAL MODIFICIATION: No information.

POST-TRANSLATIONAL MODIFICATION OF CD173: No information.


Ligands
LIGANDS AND MOLECULES ASSOCIATED WITH CD173: No information.



Function
CD173 is a biosynthetic precursor of the A and B antigens.  CD173 function is unknown but since it is expressed in some carcinomas, it can be considered a carcinoma-associated antigen.  CD173 is a specific marker of CD34+ hematopietic progenitor cells.  Fucose is involved in the adhesion of hematopoietic progenitor cells and bone marrow stromal cells.  The expression of CD173 by hematopoietic progenitors suggests a role in the homing proess of immature stem cells to bone marrow.  Expression is upregulated in the fucosylated histo-blood group antigen CD173 in CD34+ hematopoietic stem cells and downregulated expression of these antigens is in mature lymphocytes.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD173 IN INTACT ANIMAL: No information


Comments
MOLECULAR INTERACTIONS -
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD173: No information.

SUBSTRATES: No information.

ENZYMES WHICH MODIFY CD173: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
Antibodies

Revised June 25, 2008


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