|CD3d||CD3δ, Part of CD3 family, T3, Leu4|
|Molecule Type||Antigen Expression||Molecular Weight|
Min / Max
|Lineage Restricted Molecule|
Type 1 glycoprotein
|T Cell||20 / 20|
|CD3d is expressed during thymopoiesis and on mature T cells in the periphery. Less than 10% of human peripheral T cells express the g/d TCR complex but in the mouse the great majority of T cells present on some epithelial tissues are g/d + and have limited receptor diversity.|
|MOLECULAR FAMILY NAME: Belongs to the immunoglobulin supergene family.|
CD3δ is a single-pass type-1 glycoprotein. It contains an extracellular domain which contains 2 glycosylation sites, a 26-27 aa transmembrane domain and a cytoplasmic domains containing an immunorecptor tyrosine-based activation motif (ITAM). The stoichiometry of a CD3 complex is not established but is generally thought to contain a CD3d chain. The g/d heterodimers are clonotypic and consist of Ig-like variable and constant domains.
POST-TRANSCRIPTIONAL MODIFICATION: No information.
POST-TRANSLATIONAL MODIFICATION: No information.
LIGANDS AND MOLECULES ASSOCIATED WITH CD3δ
|Recognition of antigen leads to signal transduction and subsequently T cell activation.|
BIOCHEMICAL ACTIVITY: No information.
DISEASE RELEVANCE AND FUNCTION OF CD3d IN INTACT ANIMAL
Defects is CD3δ are a cause of severe combined immodeficiency (SCID).
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD3d: No information.
SUBSTRATES: No information
ENZYMES WHICH MODIFY CD3d: No information.
Database accession numbers
Revised June 25, 2008