CD3d CD3δ, Part of CD3 family, T3, Leu4
Molecule TypeAntigen ExpressionMolecular Weight
Min / Max
Lineage Restricted Molecule
Type 1 glycoprotein
T Cell
20 / 20

Expression
CD3d is expressed during thymopoiesis and on mature T cells in the periphery.  Less than 10% of human peripheral T cells express the g/d TCR complex but in the mouse the great majority of T cells present on some epithelial tissues are g/d + and have limited receptor diversity.

Structure
MOLECULAR FAMILY NAME:  Belongs to the immunoglobulin supergene family.

CD3δ is a single-pass type-1 glycoprotein.  It contains an extracellular domain which contains 2 glycosylation sites, a 26-27 aa transmembrane domain and a cytoplasmic domains containing an immunorecptor tyrosine-based activation motif (ITAM).  The stoichiometry of a CD3 complex is not established but is generally thought to contain a  CD3d chain. The g/d heterodimers are clonotypic and consist of Ig-like variable and constant domains.

MOLECULAR MASS
Cell Type Unreduced Reduced
20 kDa

POST-TRANSCRIPTIONAL MODIFICATION: No information.

POST-TRANSLATIONAL MODIFICATION:
No information.



Ligands

LIGANDS AND MOLECULES ASSOCIATED WITH CD3δ

CD3δ interacts with peptide bound to MHC molecules.



Function
Recognition of antigen leads to signal transduction and subsequently T cell activation.

BIOCHEMICAL ACTIVITY: No information.

DISEASE RELEVANCE AND FUNCTION OF CD3d IN INTACT ANIMAL

Defects is CD3δ are a cause of severe combined immodeficiency (SCID).


Comments
MOLECULAR INTERACTIONS-
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD3d: No information.

SUBSTRATES
: No information

ENZYMES WHICH MODIFY CD3
d: No information.


Database accession numbers
AnimalPIRSWISSPROTEMGBL/GENBANK
 
HumanEntrezgene 915P04234
Antibodies

Revised June 25, 2008


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